Patents by Inventor Andrew N. Bigley

Andrew N. Bigley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants of Phosphotriesterase for the Hydrolysis and Detoxification of Nerve Agents
    Publication number: 20190309273
    Abstract: Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.
    Type: Application
    Filed: May 27, 2019
    Publication date: October 10, 2019
    Applicant: The Texas A&M University System
    Inventors: Frank M. Raushel, Andrew N. Bigley
  • Variants of phosphotriesterase for the hydrolysis and detoxification of nerve agents
    Patent number: 10301608
    Abstract: Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 28, 2019
    Assignee: The Texas A&M University System
    Inventors: Frank M. Raushel, Andrew N. Bigley
  • VARIANTS OF PHOSPHOTRIESTERASE FOR THE HYDROLYSIS AND DETOXIFICATION OF NERVE AGENTS
    Publication number: 20170218348
    Abstract: Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.
    Type: Application
    Filed: June 19, 2015
    Publication date: August 3, 2017
    Applicant: The Texas A&M University System
    Inventors: Frank M. Raushel, Andrew N. Bigley