Patents by Inventor Andrew N. Cornforth

Andrew N. Cornforth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOGENIC MRNA DELIVERY VEHICLES
    Publication number: 20250134994
    Abstract: The present disclosure relates to lipid-based delivery vehicles for mRNA vaccines, which include a lysophosphatidylcholine (LPC) compound for enhancing vaccine immunogenicity. The present disclosure also relates to methods for use of the mRNA vaccines.
    Type: Application
    Filed: February 6, 2023
    Publication date: May 1, 2025
    Applicant: Corner Therapeutics, Inc.
    Inventors: Andrew N. CORNFORTH, Emily A. GOSSELIN
  • HYPERACTIVATING LIPID NANOPARTICLES
    Publication number: 20250127868
    Abstract: The present disclosure relates to lipid nanoparticles comprising a lysophosphatidylcholine (LPC) compound and at least one further lipid, and uses thereof in hyperactivating mammalian dendritic cells, such as human dendritic cells. The present disclosure also relates to compositions comprising lipid nanoparticles comprising a LPC and at least on further lipid, in which the compositions comprise one or more of a pathogen recognition receptor agonist, an antigen, and mammalian dendritic cells, as well as methods for production and use of the compositions.
    Type: Application
    Filed: February 6, 2023
    Publication date: April 24, 2025
    Applicant: Corner Therapeutics, Inc.
    Inventors: Emily A. GOSSELIN, Andrew N. CORNFORTH, Jonathan CHOW, Dania ZHIVAKI, Kelsey K. FINN
  • Methods to Enhance Tumor Immunogenicity and Compositions for Autologous Cancer Immunotherapeutic Products Using Modified Tumor Cells and Modified Dendritic Cells
    Publication number: 20220347277
    Abstract: The present specification provides methods for augmenting the antigenic content, especially of tumor-associated antigens (TAA), and immunogenicity of cancer cells; methods for enhancing cross-presentation in dendritic cells, compositions comprising such manipulated cells derived from single cancer patients; and methods of using those compositions as a personal immunotherapeutic product to treat the donor patient's cancer.
    Type: Application
    Filed: March 18, 2022
    Publication date: November 3, 2022
    Inventors: Gabriel NISTOR, Andrew N. CORNFORTH, Robert O. DILLMAN
  • Methods to Enhance Tumor Immunogenicity and Compositions for Autologous Cancer Immunotherapeutic Products Using Modified Tumor Cells and Modified Dendritic Cells
    Publication number: 20200230219
    Abstract: The present specification provides methods for augmenting the antigenic content, especially of tumor-associated antigens (TAA), and immunogenicity of cancer cells; methods for enhancing cross-presentation in dendritic cells, compositions comprising such manipulated cells derived from single cancer patients; and methods of using those compositions as a personal immunotherapeutic product to treat the donor patient's cancer.
    Type: Application
    Filed: February 16, 2018
    Publication date: July 23, 2020
    Inventors: Gabriel Nistor, Andrew N. Cornforth, Robert O. Dillman
  • HIGH PURITY OVARIAN CANCER STEM CELLS FOR ACTIVE AUTOLOGOUS IMMUNE THERAPY
    Publication number: 20160058855
    Abstract: The disclosure provides cancer stem cells, for use in stimulating immune response against a cancer, such as ovarian carcinoma. Methods for preparing and purifying the cancer stem cells are provided.
    Type: Application
    Filed: March 10, 2014
    Publication date: March 3, 2016
    Applicant: NEOSTEM ONCOLOGY, LLC
    Inventors: Andrew N. CORNFORTH, Gabriel NISTOR
  • Individualized High Purity Glioblastoma Multiforme Stem Cells and Methods for Stimulating Immune Response
    Publication number: 20160030537
    Abstract: The present disclosure provides reagents and methods for stimulating an immune response against an antigen associated with glioblastoma multiforme.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Applicant: NEOSTEM ONCOLOGY, LLC
    Inventors: Candace Y. Hsieh, Andrew N. Cornforth, Gabriel Nistor
  • Method of Induction and Purification of a Cell Population Responsible for Vascular Mimicry and Use of Same
    Publication number: 20160030535
    Abstract: The disclosure provides cancer stem cells responsible for vascular mimicry, for use in stimulating immune response against a cancer. Methods for preparing and purifying the cancer stem cells are provided.
    Type: Application
    Filed: March 10, 2014
    Publication date: February 4, 2016
    Inventors: Aleksandra J. Poole, Candace Y. Hsieh, Andrew N. Cornforth
  • INDIVIDUALIZED HIGH PURITY COLON CARCINOMA STEM CELLS, METHODS AND USE OF THE SAME
    Publication number: 20160022789
    Abstract: The disclosure provides cancer stem cells, for use in stimulating immune response against a cancer, such as colon carcinoma (CC). Methods for preparing and purifying the cancer stem cells are provided.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Applicant: NEOSTEM ONCOLOGY, LLC
    Inventors: Candace Y. Hsieh, Andrew N. Cornforth, Gabriel Nistor
  • INDIVIDUALIZED HIGH PURITY HEPATOCELLULAR CARCINOMA STEM CELLS, METHODS AND USE OF THE SAME
    Publication number: 20160017293
    Abstract: The disclosure provides cancer stem cells, for use in stimulating immune response against a cancer, such as hepatocellular carcinoma (HCC). Methods for preparing and purifying the cancer stem cells are provided.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 21, 2016
    Applicant: NEOSTEM ONCOLOGY, LLC
    Inventors: Gabriel Nistor, Craig T. Frederickson, Andrew N. Cornforth