Patents by Inventor Andrew Nicholas Knox

Andrew Nicholas Knox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide deformylase inhibitors
    Patent number: 7893056
    Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: February 22, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Donghui Qin, Beth Norton, Andrew Nicholas Knox, Siegfried B. Christensen, Kelly M. Aubart
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20090306066
    Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    Type: Application
    Filed: November 6, 2008
    Publication date: December 10, 2009
    Inventors: Donghui Qin, Beth Norton, Andrew Nicholas Knox, Siegfried B. Christensen, Kelly M. Aubart