Abstract: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

Abstract: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

Abstract: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

Abstract: A hydraulic positioning system for precisely and rapidly positioning objects of the type likely to impose impact loadings on the system. The system is particularly adaptable for use in sawmill setworks for precisely positioning logs preparatory to sawing thereof. High impact loads are compensated for by special rapid-acting shock-absorbing hydraulic relief circuitry responsive to differences between impact overpressure and system pressure.

Abstract: A hydraulic positioning system for precisely and rapidly positioning objects of the type likely to impose impact loadings on the system. The system is particularly adaptable for use in sawmill setworks for precisely positioning logs preparatory to sawing thereof. High impact loads are compensated for by special rapid-acting shock-absorbing hydraulic relief circuitry responsive to differences between impact overpressure and system pressure.

Abstract: A linear positioning cylinder drive has a piston connected at one end to a load and at the other end to a cable. The cable is secured to a pulley secured to a shaft urged in a takeup direction by a coil spring or hydraulic motor. The piston is moved by a hydraulic pump through a servo valve actuated by a circuit controlled by a transducer driven by the shaft. In one embodiment, the transducer is rotary and in another embodiment the transducer is linear.