Abstract: Methods and systems for resilient network communication are provided. In one aspect, a network includes multiple edge network elements, core network elements, and off-network network elements. Each network element has multiple ports. Communication paths exist between edge network elements, traversing core network elements. A maintenance domain maintains communication resiliency in the network through maintenance domain entities that detect network communication faults. Maintenance domain entities are associated with ports of edge network elements. Proxy maintenance domain entities, associated with unused ports of core network elements or edge network elements allow for network extensibility as additional network elements may be provisioned in the network over time.

Abstract: Provided herein is a DNA analysis method comprising a procedure that affects a first nucleobase in the DNA differently from a second nucleobase in the DNA of the first subsample; partitioning a sample into at least a first subsample and a second subsample, wherein the first subsample comprises DNA (e.g., cell-free DNA) with a nucleobase modification in a different proportion than the second subsample; and DNA is sequenced to distinguish the first nucleobase from the second nucleobase. Also provided is a combination comprising first and second populations of captured DNA, wherein the first population comprises or was derived from DNA with a nucleobase modification in a different proportion than the second population, and wherein the first population comprises a form of a first nucleobase originally present in the DNA with altered base pairing specificity and a second nucleobase without altered base pairing specificity.

Abstract: Systems and method can be provided to transform input data (e.g., CT imaging data) into structured representations to create interpretable models. Another aspect of the current invention can be generating labels synthetically to apply to real data according to a biologically-based labelling technique to guide the model training with a priori mechanistic knowledge.

Abstract: Systems, methods, and apparatuses for the detection of changes within a fluid composition while it flows in a channel. Microfluidics devices can include a detector that may include a tunable offset mechanism. The detectors can work in conjunction with an energy source that passes energy through the flow channel and into the detectors.

Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.

Abstract: The current disclosure relates to the design of an apparatus for enhancing the operation and reliability of high-power multi-chip modules, which are used in the design and implementation of power electronics converters. This apparatus is especially useful for modules containing recently-commercialized, high-performance wide band-gap semiconductors such as Silicon Carbide (SiC), which commonly emit undesirable high-frequency ringing and oscillation in the “Near-RF” spectral band between 1-30 MHz. The disclosed apparatus provides near-complete elimination of this high frequency spectral content, while leaving the desired frequency range (1-100 kHz) of the module unaffected. In addition to the suppression of this undesirable high-frequency content, the disclosed apparatus also provides for accurate, galvanically-isolated, high-bandwidth, real-time current measurement, which is essential for some types of power electronics converters.

Abstract: An ablative thruster includes a nozzle configured to control a flow of thrust from the satellite. The ablative thruster also includes an ablative surface inside of the nozzle, configured to deflect the thrust at a predefined angle. The ablative surface is configured to ablate-away, leaving un-deflected thrust for a majority of the burn.

Abstract: A cable management system includes multiple cables, each having a unique identifier associated therewith and each including first and second barcodes including the unique identifier, the first barcode located proximate a first end of the cable, the second barcode located proximate a second end of the cable. The system also includes a barcode scanner to scan barcodes of the cables, the barcode scanner includes a clip to receive one of the cables. The system also includes a mobile computing device having a processor, data storage medium, communication unit, and user interface including a display. The mobile computing device is configured to receive via the user interface first end location information for a first cable, receive from the barcode scanner the first barcode of the first cable, and save and display the first end location information in association with the unique identifier of the first cable included in the first barcode.

Abstract: Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.

Abstract: Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may have better membrane permeability compared to amisulpride. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for antagonizing dopamine and/or serotonin (e.g., 5-HT2a) and/or ?2 receptor in a subject, either individually or in combination with other CNS active agents. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for treating one or more conditions responsive to modulation of dopamine and/or serotonin (e.g., 5-HT2a) and/or ?2 receptor in a subject, either individually or in combination with other CNS active agents.

Abstract: A DNA expression construct comprising a polynucleotide encoding an unnatural UstD enzyme, the unnatural enzyme itself, and a method of making gamma-hydroxy amino acids by contacting an aldehyde-containing substrate, an amino acid, and the unnatural, purified UstD enzyme under conditions and for a time sufficient to react at least a portion of the aldehyde-containing substrate with at least a portion of the amino acid, to yield a gamma-hydroxy amino acid product.

Abstract: Superconducting integrated circuits may advantageously employ superconducting resonators coupled to a microwave transmission line to efficiently address superconducting flux storage devices. In an XY-addressing scheme, a global flux bias may be applied to a number of superconducting flux storage devices via a low-frequency address line, and individual superconducting flux storage devices addressed via application of high-frequency pulses via resonators driven by the microwave transmission line. Frequency multiplexing can be employed to provide signals to two or more resonators. A low-frequency current bias may be combined with a high-frequency current in one or more superconducting resonators to provide Z-addressing. A low-frequency current bias may be combined with a high-frequency current in one or more superconducting resonators to eliminate a flux bias line.

Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: A cascode bias circuit biases a gate of a cascode transistor in a cascode current mirror. The cascode bias circuit includes a first transistor configured to conduct a first current and includes a second transistor configured to conduct a second current. The first and second transistors couple to a third transistor configured to conduct a sum of the first current and the second current. A gate of the first transistor couples to a gate of the cascode transistor to bias the cascode transistor.

Abstract: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.

Abstract: Provided herein are antibody drug conjugates of Formula (I): G-R7(I) and pharmaceutically acceptable salts thereof, wherein G is a molecular payload; and R7 is -L-A-B, wherein L is a linking group, A is a conjugating group, and B is an antibody or antibody fragment. Also provided are methods of preparing the antibody-drug conjugates, pharmaceutically acceptable compositions thereof, and methods of their use and treatment. Further provided are precursors to the antibody drug conjugates (e.g., compounds of Formula (III), novel trioxacarcins without an antibody conjugated thereto), pharmaceutical compositions thereof, and methods of their use and treatment.

Abstract: A computer-implemented method is disclosed. The method includes causing display, in a graphical user interface on a client device, of a page with a navigational panel including a selectable tree element having a hierarchical relationship to a current electronic page having its user-generated content being displayed in a content panel. The method includes identifying a set of candidate cards in which each card is associated with a respective electronic page and has a respective relatedness score. The method includes identifying a user profile in accordance with an authentication of an user operating the client device, and selecting, from the set of candidate cards, a subset of candidate cards satisfying permissions criteria based on permissions identified in the user profile. The method includes causing display of the subset of candidate cards within the content panel in accordance with the respective relatedness score for each card in the subset of candidate cards.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: Disclosed herein are disposable devices for measuring sweat having low dead volumes and allowing a quick sensory response. Also disclosed herein are methods of making and using such devices.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.