Abstract: Systems and methods for an entropy coding system are described. The entropy coding systems include an encoding apparatus and a decoding apparatus. The encoding apparatus is configured to receive an original input stream comprising a plurality of symbols having a known entropy characteristic according to a probability distribution of each of the symbols appearing in the original input stream, determine an input and respective state for each symbol read from the original input stream, append the determined input to the encoded output stream, and provided the encoded output stream to the decoding apparatus. The decoding apparatus is configured to receive the encoded output stream, process the encoded output stream, and for each read input: determine an output symbol and a respective output, persist the respective output state to the encoded output stream, and append the determined output symbol to the results output stream.

Abstract: Methods and apparatus (10) for Raman spectral analysis of a sample (12), such as a pharmaceutical dosage form, are disclosed. Delivery optics (16) are used to deliver probe light to a delivery region (13) on the sample, and collection optics (20) are used to collect, from a collection region (17) on the sample spaced from the delivery region, the probe light following scattering through the sample. Each of a plurality of target Raman spectral features are measured in the collected light, and a spectral distortion of the collected light arising during scattering through the sample is determined. A property of the sample is then quantified using the target Raman spectral features in combination with the determined spectral distortion, such that the quantified property is compensated for the spectral distortion.

Abstract: The present invention relates to solid compositions comprising microparticles of glecaprevir and/or pibrentasvir dispersed within a matrix comprising a first excipient and a second excipient. The present invention also relates to microneedle arrays, implantable rods, aqueous dispersions, and pharmaceutical compositions derived from said solid compositions and uses for the same.

Abstract: The present invention relates to solid compositions of pharmaceutically active compounds, aqueous dispersions derived from these compositions and processes for the preparation of these solid compositions and dispersions. The present invention also relates to pharmaceutical compositions derived from these solid compositions and dispersions, and their use in the treatment and/or prophylaxis of helminthic, protozoal, and viral infections.

Abstract: Methods and apparatus (10) for Raman spectral analysis of a sample (12), such as a pharmaceutical dosage form, are disclosed. Delivery optics (16) are used to deliver probe light to a delivery region (13) on the sample, and collection optics (20) are used to collect, from a collection region (17) on the sample spaced from the delivery region, the probe light following scattering through the sample. Each of a plurality of target Raman spectral features are measured in the collected light, and a spectral distortion of the collected light arising during scattering through the sample is determined. A property of the sample is then quantified using the target Raman spectral features in combination with the determined spectral distortion, such that the quantified property is compensated for the spectral distortion.

Abstract: A solid composition comprising nanoparticles of atovaquone dispersed within one or more carrier materials, wherein the atovaquone is present in an amount of at least 10 wt %. Also described is an intramuscularly- or subcutaneously-injectable formulation of nanoparticles of atovaquone.

Abstract: Modular containerization systems and methods may include a plurality of modular units that may be removably coupled together in various configurations. Each modular unit may receive a container, and each container may receive one or more objects. In addition, each modular unit may include various sensors and processing aid or indicators, such as a container presence sensor, a scale, a stow-to-light indicator, a container complete button and indicator, and a container removal indicator. Further, each modular unit of a modular container system may be in communication with a controller to coordinate various processes associated with the system, including container placement, container filling, and container removal processes using the various sensors and processing aids or indicators.

Abstract: The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

Abstract: A material for an injection nozzle is molded into a form that includes a sacrificial tip around the nozzle exit orifice. The sacrificial tip is then machined away using any suitable machining process to expose the exit orifice. In this manner, an injection nozzle can be fabricated with favorable geometric characteristics.

Abstract: A STATCOM arrangement includes an MMC and a transformer arrangement arranged to be an interface between the MMC and an AC grid. The MMC is connected in a wye topology with a plurality of converter arms, one for each phase of the AC grid, each arm including a plurality of chain-linked converter cells. The transformer arrangement is arranged to interface each of the arms of the MMC with a respective phase of the grid, and arranged to for each of the converter arms produce leakage reactance resulting in reactance in series with the arm which obviates the need for a phase reactor connected in series with said arm.

Abstract: An apparatus for transporting a load is described, including: a body including a part or portion for engaging with or connecting to a load to be transported; a ground-engaging device supporting the body, the ground-engaging device for effecting movement of the body over a surface; a transmitter module; a receiver module; and a controller for communicating with the transmitter and receiver modules and the ground engaging device and for receiving status signals from components and/or devices of the apparatus, wherein the controller is capable of conducting a check as to the status of the components and/or devices of the apparatus, and after completing said check to provide an “apparatus operative” or “apparatus non-operative” signal to the transmitter module, wherein the transmitter module is configured to transmit the “apparatus operative” or “apparatus non-operative” signal to a receiver module of one or more other apparatus and to its own receiver module.

Abstract: An apparatus for transporting a load is described, including: a body including a part or portion for engaging with or connecting to a load to be transported; a ground-engaging device supporting the body, the ground-engaging device for effecting movement of the body over a surface; a transmitter module; a receiver module; and a controller for communicating with the transmitter and receiver modules and the ground engaging device and for receiving status signals from components and/or devices of the apparatus, wherein the controller is capable of conducting a check as to the status of the components and/or devices of the apparatus, and after completing said check to provide an “apparatus operative” or “apparatus non-operative” signal to the transmitter module, wherein the transmitter module is configured to transmit the “apparatus operative” or “apparatus non-operative” signal, and wherein the receiver module is configured to receive from a first predetermined, or designated, other such apparatus its respective

Abstract: Polymer-of-prodrug (POP) materials enable new nucleoside reverse transcriptase inhibitor (NRTI) therapy strategies. The materials are prodrugs of NRTIs in the form of polymers. Suitable materials include products which are polymeric NRTI delivery systems comprising polymeric materials which are capable of degradation after administration to release NRTIs or NRTI prodrugs which themselves are capable of metabolism to the parent NRTIs. The NRTIs may optionally be selected from tenofovir (TFV), emtricitabine (FTC), lamivudine (3TC) and MK-8591 (EFdA). The invention facilitates long-acting (LA) regimens. Constructs of the materials may be in the form of injectable compositions or implants.

Abstract: The present invention provides a solid composition comprising nanoparticles comprising at least one water-insoluble active and at least one oil, dispersed within a water-soluble mixture of at least one hydrophilic polymer and at least one surfactant. Process for preparing such solid compositions and aqueous dispersions of such compositions are also provided.

Abstract: The present disclosure relates to a STATCOM arrangement (1) comprising an MMC (2) and a transformer arrangement (3) arranged to be an interface between the MMC (2) and an AC grid. The MMC (2) is connected in a wye topology with a plurality of converter arms, one for each phase of the AC grid, each arm comprising a plurality of chain-linked converter cells. The transformer arrangement (3) is arranged to interface each of the arms of the MMC (2) with a respective phase of the grid, and arranged to for each of the converter arms produce leakage reactance resulting in reactance in series with the arm which obviates the need for a phase reactor connected in series with said arm.

Abstract: Cyclic peptide compounds are provided that can bind to one or more homologs of Hedghehog signaling proteins and block their interaction with the Patched receptor. These compounds are useful for suppressing Hedgehog-dependent stimulation of the Hedgehog pathway in cells and in living organisms. Methods for using the cyclic peptide compounds, and compositions comprising them, for treatment of cancers and other diseases which are characterized by aberrant Hedgehog-dependent activation of the Hedgehog pathway and/or which can benefit from chemical suppression of Hedgehog-dependent signaling are also disclosed.

Abstract: A needle-free injector includes a housing, a cartridge positioned within the housing, and a plunger slidably coupled to and disposed within the chamber, a motor operatively coupled to the plunger, the motor operable to actuate the plunger in the chamber, and a controller operatively coupled to the motor. Methods of delivering an injectate using the needle-free injectors are provided. Methods of facilitating needle-free injection of a fluid using the needle-free injectors are also provided.

Abstract: Particles comprising a branched polymer and either a block copolymer or a linear dendritic hybrid represent a category of useful materials. They may be used in for example drug delivery applications. They may be prepared by a method comprising the steps of: dissolving the branched polymer and block copolymer or linear dendritic hybrid, and optionally other component(s), in a solvent to form a solution; adding said solution to a different liquid; and removing said solvent to form a dispersion of co-precipitated particles.

Abstract: Systems and methods of processing business related data arising from multiple revenue sources (e.g., sales, subscriptions, professional services, vendors, etc.). In some embodiments, the inventive system and methods enable a more flexible and efficient approach to identifying revenue source events (mediation), pricing those events (typically as part of a rating process), and subsequently leveraging those “ratable events” in the billing and revenue recognition subsystems according to configurable rules and schedules. Data regarding those charges or other aspects of a ratable event may then be used and processed by multiple sub-systems that are part of operating a business; such sub-systems may include one or more of ERP, CRM, HCM, financial, accounting, taxation, or other business-related system or function.