Patents by Inventor Andrew P. Bartko

Andrew P. Bartko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10436682
    Abstract: A Raman silent substrate includes a base and a biologically compatible material layer over the base. The biologically compatible material layer is Raman silent, provides a predetermined capture efficiency corresponding to a desired application, and supports biological culturing. In certain implementations, the base comprises a glass layer and an aluminum layer between the glass layer and the biologically compatible material layer.
    Type: Grant
    Filed: May 29, 2016
    Date of Patent: October 8, 2019
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Andrew P. Bartko, Theodore J. Ronningen
  • Patent number: 10401297
    Abstract: Detecting threat materials used in explosives is performed by receiving a sample, and selecting an area of interest on the sample suspected of containing a threat material indicative of an explosive. Detection also includes interrogating the area of interest with a Raman laser producing a Raman spectrum, and comparing an amplitude of a first spectral region in the Raman spectrum to a first predetermined threshold. Detection further includes performing a verification, if the determination indicates that the area of interest includes the threat material, by checking the interrogated area of interest for a secondary indicator of the presence of the threat material, by comparing an amplitude of a second spectral region in the Raman spectrum, which is different from the first spectral region in the Raman spectrum, to a second predetermined threshold, and activating an indicator if the verification indicates that the area of interest contains the threat material.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: September 3, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Andrew P. Bartko, Theodore J. Ronningen
  • Patent number: 10308905
    Abstract: A method of removing a phenol contaminant from a beer or wine comprising contacting the beer or wine with a surface comprising a phenol contaminant effective removing amount of a poly(N-vinyl-2-pyrrolidone).
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: June 4, 2019
    Assignee: ISP INVESTMENTS LLC
    Inventors: Mustafa Rehmanji, Andrew Mola, Joseph P. Bartko
  • Patent number: 10207276
    Abstract: A small area electrostatic aerosol collector combines electrostatic collection of aerosol particles and electrohydrodynamic spraying of fluid so that a sample collected electrostatically can have fluid applied thereto. The fluid may assist with disaggregation and/or desalinization of biological material collected onto a sample substrate. A controller associated with the collector may control an electrostatic charge device and a spraying device such that the charge device and spraying device may operate in alternating fashion, or the charge device and spraying device may operate simultaneously. Further, mechanical systems are provided, for the disaggregation of particulate clusters collected onto a sample substrate.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: February 19, 2019
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Andrew P. Bartko, Rodney S. Black, James R. Busch, David R. Chase, Ryan W. Daly, Theodore J. Ronningen, Matthew S. Young
  • Patent number: 10126169
    Abstract: An apparatus comprises: a microscope objective focused on a microscope field of view; a light source including a laser generating an astigmatic beam and optics configured to couple the astigmatic beam into the microscope objective to produce high aspect ratio illumination at the microscope field of view; and a data acquisition system configured to generate data pertaining to light emanating from the microscope field of view responsive to the high aspect ratio illumination. The apparatus may be a Raman spectroscopy system. The laser may be an edge emitting laser. The optics of the light source may include an aspherical lens arranged to compensate the astigmatism of the astigmatic beam. The optics of the light source may include a diffraction grating arranged respective to the laser to provide feedback reducing a spectral full width at half maximum (FWHM) of the astigmatic beam.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: November 13, 2018
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Bradley B. Ross, Andrew P. Bartko
  • Publication number: 20180306722
    Abstract: Detecting threat materials used in explosives is performed by receiving a sample, and selecting an area of interest on the sample suspected of containing a threat material indicative of an explosive. Detection also includes interrogating the area of interest with a Raman laser producing a Raman spectrum, and comparing an amplitude of a first spectral region in the Raman spectrum to a first predetermined threshold. Detection further includes performing a verification, if the determination indicates that the area of interest includes the threat material, by checking the interrogated area of interest for a secondary indicator of the presence of the threat material, by comparing an amplitude of a second spectral region in the Raman spectrum, which is different from the first spectral region in the Raman spectrum, to a second predetermined threshold, and activating an indicator if the verification indicates that the area of interest contains the threat material.
    Type: Application
    Filed: May 29, 2018
    Publication date: October 25, 2018
    Inventors: Andrew P. Bartko, Theodore J. Ronningen
  • Patent number: 9983138
    Abstract: A method for determining whether a sample includes a nitrate-based explosive comprises receiving the sample and selecting an area of interest on the sample. Then, at least a portion of the area of interest is interrogated with an optical source to produce a spectrum with an amplitude. The amplitude of a first portion of the spectrum is compared to a first predetermined threshold to determine if the sample includes a nitrate. After determining that the sample includes a nitrate in the area of interest, the amplitude of a second portion of the spectrum is compared to a second predetermined threshold to determine if the sample includes a secondary indicator. Then, an indicator is activated based on the determinations.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: May 29, 2018
    Assignee: Battelle Memorial Institute
    Inventors: Andrew P. Bartko, Theodore J. Ronningen
  • Patent number: 9856505
    Abstract: A manufacturing method comprises collecting a sample from a cell culture used by a manufacturing application, and controlling a Raman spectrometer to collect a Raman spectrum of a targeted volume within the sample. The method further comprises obtaining reference spectra uniquely associated with a known cell line, which comprise at least two of: spectral measurements of mycoplasma by itself, a contaminated cell line, and a pure cell line. Moreover, the method comprises comparing the reference spectra to the collected spectrum, and identifying whether there is at least one unnatural molecular composition within the collected spectrum based upon the comparison of the reference spectra to the collected spectrum. An indication is provided as to whether mycoplasma is detected in the collected Raman spectrum where at least one unnatural molecular composition is identified within the collected spectrum, and the manufacturing application is stopped where mycoplasma is detected in the collected Raman spectrum.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: January 2, 2018
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventor: Andrew P. Bartko
  • Publication number: 20170299521
    Abstract: A method for determining whether a sample includes a nitrate-based explosive comprises receiving the sample and selecting an area of interest on the sample. Then, at least a portion of the area of interest is interrogated with an optical source to produce a spectrum with an amplitude. The amplitude of a first portion of the spectrum is compared to a first predetermined threshold to determine if the sample includes a nitrate. After determining that the sample includes a nitrate in the area of interest, the amplitude of a second portion of the spectrum is compared to a second predetermined threshold to determine if the sample includes a secondary indicator. Then, an indicator is activated based on the determinations.
    Type: Application
    Filed: October 13, 2016
    Publication date: October 19, 2017
    Inventors: Andrew P. Bartko, Theodore J. Ronningen
  • Publication number: 20160320235
    Abstract: An apparatus comprises: a microscope objective focused on a microscope field of view; a light source including a laser generating an astigmatic beam and optics configured to couple the astigmatic beam into the microscope objective to produce high aspect ratio illumination at the microscope field of view; and a data acquisition system configured to generate data pertaining to light emanating from the microscope field of view responsive to the high aspect ratio illumination. The apparatus may be a Raman spectroscopy system. The laser may be an edge emitting laser. The optics of the light source may include an aspherical lens arranged to compensate the astigmatism of the astigmatic beam. The optics of the light source may include a diffraction grating arranged respective to the laser to provide feedback reducing a spectral full width at half maximum (FWHM) of the astigmatic beam.
    Type: Application
    Filed: July 11, 2016
    Publication date: November 3, 2016
    Inventors: Bradley B. Ross, Andrew P. Bartko
  • Publication number: 20160274101
    Abstract: A Raman silent substrate includes a base and a biologically compatible material layer over the base. The biologically compatible material layer is Raman silent, provides a predetermined capture efficiency corresponding to a desired application, and supports biological culturing. In certain implementations, the base comprises a glass layer and an aluminum layer between the glass layer and the biologically compatible material layer.
    Type: Application
    Filed: May 29, 2016
    Publication date: September 22, 2016
    Inventors: Andrew P. Bartko, Theodore J. Ronningen
  • Publication number: 20160208305
    Abstract: A manufacturing method comprises collecting a sample from a cell culture used by a manufacturing application, and controlling a Raman spectrometer to collect a Raman spectrum of a targeted volume within the sample. The method further comprises obtaining reference spectra uniquely associated with a known cell line, which comprise at least two of: spectral measurements of mycoplasma by itself, a contaminated cell line, and a pure cell line. Moreover, the method comprises comparing the reference spectra to the collected spectrum, and identifying whether there is at least one unnatural molecular composition within the collected spectrum based upon the comparison of the reference spectra to the collected spectrum. An indication is provided as to whether mycoplasma is detected in the collected Raman spectrum where at least one unnatural molecular composition is identified within the collected spectrum, and the manufacturing application is stopped where mycoplasma is detected in the collected Raman spectrum.
    Type: Application
    Filed: March 28, 2016
    Publication date: July 21, 2016
    Inventor: Andrew P. Bartko
  • Patent number: 9389121
    Abstract: An apparatus comprises: a microscope objective focused on a microscope field of view; a light source including a laser generating an astigmatic beam and optics configured to couple the astigmatic beam into the microscope objective to produce high aspect ratio illumination at the microscope field of view; and a data acquisition system configured to generate data pertaining to light emanating from the microscope field of view responsive to the high aspect ratio illumination. The apparatus may be a Raman spectroscopy system. The laser may be an edge emitting laser. The optics of the light source may include an aspherical lens arranged to compensate the astigmatism of the astigmatic beam. The optics of the light source may include a diffraction grating arranged respective to the laser to provide feedback reducing a spectral full width at half maximum (FWHM) of the astigmatic beam.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: July 12, 2016
    Assignee: Battelle Memorial Institute
    Inventors: Bradley B. Ross, Andrew P. Bartko
  • Patent number: 9354146
    Abstract: A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: May 31, 2016
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Andrew P. Bartko, Johnway Gao
  • Patent number: 9334520
    Abstract: Mycoplasma contamination of a known cell line is detected by collecting a Raman spectrum of a targeted volume within a sample, the targeted volume containing a known cell line of interest, obtaining a reference spectrum uniquely associated with the known cell line where the obtained reference spectrum is known to be free of mycoplasma and comparing, using a processing device, the reference spectrum to the collected spectrum. Mycoplasma is further detected by identifying whether there are unnatural molecular compositions within the collected spectrum based upon the comparison of the reference spectrum to the collected spectrum and providing an indication as to whether mycoplasma is detected in the collected Raman spectrum based upon whether unnatural molecular compositions are identified within the collected spectrum.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: May 10, 2016
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventor: Andrew P. Bartko
  • Publication number: 20160045920
    Abstract: A small area electrostatic aerosol collector combines electrostatic collection of aerosol particles and electrohydrodynamic spraying of fluid so that a sample collected electrostatically can have fluid applied thereto. The fluid may assist with disaggregation and/or desalinization of biological material collected onto a sample substrate. A controller associated with the collector may control an electrostatic charge device and a spraying device such that the charge device and spraying device may operate in alternating fashion, or the charge device and spraying device may operate simultaneously. Further, mechanical systems are provided, for the disaggregation of particulate clusters collected onto a sample substrate.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Inventors: Andrew P. Bartko, Rodney S. Black, James R. Busch, David R. Chase, Ryan W. Daly, Theodore J. Ronningen, Matthew S. Young
  • Patent number: 9200987
    Abstract: A small area electrostatic aerosol collector combines electrostatic collection of aerosol particles and electrohydrodynamic spraying of fluid so that a sample collected electrostatically can have fluid applied thereto. The fluid may assist with disaggregation and/or desalinization of biological material collected onto a sample substrate. A controller associated with the collector may control an electrostatic charge device and a spraying device such that the charge device and spraying device may operate in alternating fashion, or the charge device and spraying device may operate simultaneously. Further, mechanical systems are provided, for the disaggregation of particulate clusters collected onto a sample substrate.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: December 1, 2015
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Andrew P. Bartko, Rodney S. Black, James R. Busch, David R. Chase, Ryan W. Daly, Theodore J. Ronningen, Matthew S. Young
  • Publication number: 20150219535
    Abstract: A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.
    Type: Application
    Filed: April 17, 2015
    Publication date: August 6, 2015
    Inventors: Andrew P. Bartko, Johnway Gao
  • Patent number: 9034278
    Abstract: A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: May 19, 2015
    Assignee: Battelle Memorial Institute
    Inventors: Andrew P. Bartko, Johnway Gao
  • Publication number: 20140178924
    Abstract: Mycoplasma contamination of a known cell line is detected by collecting a Raman spectrum of a targeted volume within a sample, the targeted volume containing a known cell line of interest, obtaining a reference spectrum uniquely associated with the known cell line where the obtained reference spectrum is known to be free of mycoplasma and comparing, using a processing device, the reference spectrum to the collected spectrum. Mycoplasma is further detected by identifying whether there are unnatural molecular compositions within the collected spectrum based upon the comparison of the reference spectrum to the collected spectrum and providing an indication as to whether mycoplasma is detected in the collected Raman spectrum based upon whether unnatural molecular compositions are identified within the collected spectrum.
    Type: Application
    Filed: February 27, 2014
    Publication date: June 26, 2014
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventor: Andrew P. Bartko