Abstract: Composite grafts and implantable medical devices include a polymeric layer and a non-porous silicone coating that includes a two-part dispersion of silicone material in an organic solvent. The polymeric layer has a first surface and a second surface, where the first surface and the second surface are positioned on opposite sides of the polymeric layer, and where the first surface is the blood-contacting surface and the second surface is the tissue-contacting surface. The non-porous silicone coating includes a two-part dispersion of silicone material in an organic solvent. The silicone coating is disposed on at least the first surface of the polymeric layer such that the at least first surface or a portion thereof has a substantially reduced permeability or is entirely impermeable. The coating does not substantially increase the thickness of the medical device and reduces the surface friction of the medical device while making the graft layer impermeable to fluids.

Abstract: The present disclosure generally provides a stent-graft for insertion into a body vessel that comprises hydrophilic polyurethane hydrogel cuffs and an elongated cylindrical body. This stent-graft exhibits an enhanced ability to maintain its original position when placed into a patient and resist the potential of migration without causing excessive discomfort to the patient. Upon exposure to bodily fluids, the cuffs of the stent-graft expand to exert a sealing or anchoring force against the wall of the body vessel. Such a stent-graft overcomes many of the problems associated with conventional stent-grafts as currently used in many different applications, for example, endovascular repair and ureteral drainage.

Abstract: One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.

Abstract: The present invention provides an implantable medical device comprising a bioactive agent and poly(alkyl cyanoacrylate) polymer. In one embodiment of the invention, the bioactive agent is a water-soluble material, such as an antisense agent.

Abstract: Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device.

Abstract: An occlusion device includes a tubular expandable body with a frame that has a plurality of interconnected members configured to expand within a body vessel and to collapse for delivery or retrieval of the device. The occlusion device further includes a hydrophilic polyurethane hydrogel layer attached to the interconnected members of the tubular expandable body. The polyurethane hydrogel layer expands upon exposure to an aqueous environment.

Abstract: Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device.

Abstract: A device and method for delivering a bioactive to the uterine wall. In one embodiment, the device comprises a balloon having the bioactive present within the material of the balloon or on an outside surface of the balloon. Another embodiment provides a method comprising inserting the balloon into the uterus, inflating the balloon so that the outside surface of the balloon exerts pressure on uterine wall and delivering the bioactive to the uterine wall.