Abstract: The compositions and methods of the disclosure can be used to produce a cannabinoid in a host cell, such as a yeast cell. For example, the disclosure features host cells (e.g., yeast cells) modified to express one or more enzymes of a cannabinoid biosynthetic pathway, such as an acyl activating enzyme (AAE), a tetraketide synthase (TKS), a cannabigerolic acid synthase (CBGaS), and/or an olivetolic acid cyclase (OAC).

Abstract: Provided herein are genetically modified host cells, compositions, and methods for improved production of steviol glycosides. The host cells are genetically modified to contain a heterologous nucleic acid that expresses novel and optimized variants of Ro.KAH. The host cell further contains one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing one or more steviol glycosides in the host cell. The host cells, compositions, and methods described herein provide an efficient route for the heterologous production of steviol glycosides including rebaudioside A, rebaudioside D, and rebaudioside M.

Abstract: Provide are modified host cells that are engineered to decrese expression of a product to undetectable levels in the presence of an exogenous agent, and increase expression of the product in the presence of another exogenous agent. The modified yeast strainshost cells do not express detectable levels of a precursor or substrate used to make the product. The product can be a cannabinoid or precursor thereof, and the substrate can be hexanoate. Also provided are methods for making a product using the modified host cells. The modified host cell can be a yeast strain, such as S. cerevisiae.

Abstract: Described herein are absorbent articles and methods of making such articles. The articles are made by bonding a copolymer onto a substrate to form a core. The absorbent articles are particularly useful in personal care product, e.g., disposable hygiene products.

Abstract: Recoaters are described which are adapted for use in powder-layer three-dimensional printers. The recoaters comprise a mesh discharge device that is adapted to be selectively activated by the application of an agitation, e.g. a vibration. Such mesh discharge devices include a planar mesh, i.e. a screen or sieve, which is adapted to support a quantity of powder when the quantity of powder and the mesh are static and to dispense at least a portion of the quantity of powder when at least one of the quantity of powder and the mesh is agitated. Preferably, the mesh is disposed substantially horizontally, but may be disposed at an angle to the horizontal. Also described are powder-layer three-dimensional printers comprising such recoaters. In some embodiments, the powder-layer three-dimensional printers are adapted to space the mesh no more than about two to ten powder layer thicknesses from the top surface of the powder bed or substrate upon which a powder layer is to be deposited.

Abstract: Polymeric materials are disclosed herein that include a Polymer A, a Polymer B, and an oxalate ester or reaction product thereof. Polymer A contains electrophilic reactive groups, and Polymer B contains nucleophilic groups. In certain embodiments, the polymeric materials are free-flowing liquids at 100% solids that can be used, for example, as topical skin adhesives.

Abstract: Polymeric materials are disclosed herein that include a Polymer A, a Polymer B, and an oxalate ester or reaction product thereof. Polymer A contains electrophilic reactive groups, and Polymer B contains nucleophilic groups. In certain embodiments, the polymeric materials are free-flowing liquids at 100% solids that can be used, for example, as topical skin adhesives.

Abstract: Polymeric materials are disclosed herein that include a reaction product of components comprising: a) a first amine component having at least two and at most three primary amino groups, secondary amino groups, or a mixture thereof, with the proviso that the first amine component is not a silicone diamine; b) a second amine component having (i) greater than three primary amino groups, or (ii) at least three primary amino groups and a plurality of secondary amino groups, wherein the second amine component is a polymeric material having a carbon backbone or a polymeric material having a carbon backbone with a plurality of catenated nitrogen atoms; and c) an oxalate ester.

Abstract: Polymeric materials are disclosed herein that include a reaction product of components comprising: a) a first amine component having at least two and at most three primary amino groups, secondary amino groups, or a mixture thereof, with the proviso that the first amine component is not a silicone diamine; b) a second amine component having (i) greater than three primary amino groups, or (ii) at least three primary amino groups and a plurality of secondary amino groups, wherein the second amine component is a polymeric material having a carbon backbone or a polymeric material having a carbon backbone with a plurality of catenated nitrogen atoms; and c) an oxalate ester.

Abstract: Described herein are absorbent articles made by bonding a copolymer onto a substrate to form a core. The absorbent articles are particularly useful in personal care product, e.g., disposable hygiene products. In some embodiments, the absorbent article includes a first substrate; and a copolymer irreversibly bonded onto the first substrate to form a core, wherein the copolymer is derived from a polymerizable solution comprising: (a) a first monomer selected from a (meth)acrylic acid or salt thereof; (b) greater than 1 wt % of a second monomer, wherein the second monomer is a hydrophilic crosslinking monomer, and (c) a polymeric porogen.

Abstract: A device for applying powder layers across a substrate or atop an existing powder bed is disclosed. The device has particular utility in embodiments which are adapted for use in depositing powder layers for three-dimensional printing and as part of a three-dimensional printing apparatus. The device utilizes a conveyor belt to transfer powder from a powder reservoir and deposit it upon powder bed or other substrate. In some embodiments, the device utilizes a conveyor belt in conjunction with a powder deflector to transfer powder from a powder reservoir and deposit it upon powder bed or other substrate. In some embodiments the conveyor belt has a downwardly inclined section. In some embodiments, a downwardly inclined chute is used in conjunction with the conveyor belt.

Abstract: Described herein are absorbent articles and methods of making such articles. The articles are made by bonding a copolymer onto a substrate to form a core. The absorbent articles are particularly useful in personal care product, e.g., disposable hygiene products.

Abstract: Described herein are absorbent articles and methods of making such articles. The articles are made by bonding a copolymer onto a substrate to form a core. The absorbent articles are particularly useful in personal care product, e.g., disposable hygiene products.

Abstract: Recoaters are described which are adapted for use in powder-layer three-dimensional printers. The recoaters comprise a mesh discharge device that is adapted to be selectively activated by the application of an agitation, e.g. a vibration. Such mesh discharge devices include a planar mesh, i.e. a screen or sieve, which is adapted to support a quantity of powder when the quantity of powder and the mesh are static and to dispense at least a portion of the quantity of powder when at least one of the quantity of powder and the mesh is agitated. Preferably, the mesh is disposed substantially horizontally, but may be disposed at an angle to the horizontal. Also described are powder-layer three-dimensional printers comprising such recoaters. In some embodiments, the powder-layer three-dimensional printers are adapted to space the mesh no more than about two to ten powder layer thicknesses from the top surface of the powder bed or substrate upon which a powder layer is to be deposited.

Abstract: Powder-layer three-dimensional printer recoaters, which are adapted for use with fine powders, are disclosed. The recoaters comprise a controllably vibrated traveling powder dispenser having a hopper section adapted to contain the build powder, an opening through which the powder can be controllably discharged laterally into a chamber which is located beside the opening and which has a mesh covering at least a portion of its bottom. The recoaters also comprise a vibrator that is operably connected to the traveling powder dispenser and is adapted to selectively cause the powder to flow from the hopper through the opening and be discharged through the mesh. In some embodiments, the recoaters also comprise a smoothing device which is adapted to smoothen the powder dispensed through the mesh. In some embodiments the smoothing device is adapted to compact the density of the dispensed powder level a selectable amount. Also disclosed are powder-layer three-dimensional printers having such recoaters.

Abstract: A system for supplying a pre-determined ratio of liquid foam concentrate and water to a mixing device immediately upstream from a fire fighting nozzle. The system is electronically balanced by measuring pressure from a plurality of pressure signal sensors and transmitting said pressure signals to a controller unit. A foam additive pump is powered by a fixed displacement piston motor which in turn is electronically modulated independently of the level of operation of the water pump by a control system that is responsive both to the water pressure developed by the water pump and to the foam liquid concentrate pressure developed by the additive pump.

Abstract: A system and method of maintaining a desired additive to water ration in a fire-fighting system including a water flow sensor configured to measure the water flow rate, a water pump, a hydraulic pump, a linear hydraulic cylinder driven by the hydraulic pump, an additive pump mechanically coupled to the linear hydraulic cylinder; and a pump displacement sensor configured to sense the position of the additive pump, the pump displacement sensor being in communication with the water flow sensor to maintain a pre-determined ratio of additive to water.

Abstract: A system and method of maintaining a desired additive to water ration in a fire-fighting system including a water flow sensor configured to measure the water flow rate, a water pump, a hydraulic pump, a linear hydraulic cylinder driven by the hydraulic pump, an additive pump mechanically coupled to the linear hydraulic cylinder; and a pump displacement sensor configured to sense the position of the additive pump, the pump displacement sensor being in communication with the water flow sensor to maintain a pre-determined ratio of additive to water.