Abstract: Described are systems and methods of predicting a response to a medical treatment in a subject. The systems and methods include the steps of selecting a set of mutations within at least one biological process, training a set of classifiers from the set of selected mutations via a training dataset, determining the performance level of each classifier via a validation dataset, applying a subset of high-performance level classifiers from the validation dataset via a test dataset, and predicting the response to the medical treatment based on the test dataset.

Abstract: Apparatus and methods for a modified Doherty amplifier operating at gigahertz frequencies are described. The combining of signals from a main amplifier and a peaking amplifier occur prior to impedance matching of the amplifier's output to a load. An output impedance-matching element can be relied upon. In one example, the output impedance-matching element can include an output strip line, a shunt capacitor connected between the output strip line and ground, an output capacitor connected between the output strip line and an output bonding pad, and an inductive strip line connected between the output bonding pad and ground.

Abstract: Apparatus and methods for a modified Doherty amplifier operating at gigahertz frequencies are described. The combining of signals from a main amplifier and a peaking amplifier occur prior to impedance matching of the amplifier's output to a load. An output impedance-matching element can be relied upon. In one example, the output impedance-matching element can include an output strip line, a shunt capacitor connected between the output strip line and ground, an output capacitor connected between the output strip line and an output bonding pad, and an inductive strip line connected between the output bonding pad and ground.

Abstract: Apparatus and methods for a modified Doherty amplifier operating at gigahertz frequencies are described. The combining of signals from a main amplifier and a peaking amplifier occur prior to impedance matching of the amplifier's output to a load. An integrated distributed inductor may be used in an impedance inverter to combine the signals. A size of the impedance element can be selected by patterning during manufacture to tune the amplifier and to allow power scaling for the amplifier.

Abstract: The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3? end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Abstract: A multi-voltage converter is described that includes integrated temperature-protection circuitry. The converter may be used to bias radio-frequency components such as PIN diodes and gallium-nitride devices, and may include integrated bias-sequencing circuitry. Programmable output voltages as high as 30 volts and as low as ?20 volts may be generated.

Abstract: A multi-voltage converter is described that includes integrated temperature-protection circuitry. The converter may be used to bias radio-frequency components such as PIN diodes and gallium-nitride devices, and may include integrated bias-sequencing circuitry. Programmable output voltages as high as 30 volts and as low as ?20 volts may be generated.

Abstract: The disclosure relates to compositions comprising a HBV RNAi agent. In some embodiments, the HBV RNAi agent comprises a sense and an anti-sense strand, each strand being an 18-mer and the strands together forming a blunt-ended duplex, wherein the 3? end of at least one strand terminates in a phosphate or modified internucleoside linker and further comprises, in 5? to 3? order: a spacer; a second phosphate or modified internucleoside linker; and a 3? end cap. In some embodiments, the 3? end of both the sense and anti-sense strand further comprise, in 5? to 3? order: a spacer; a second phosphate or modified internucleoside linker; and a 3? end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3? end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker.

Abstract: The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3? end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Abstract: Apparatus and methods for a modified Doherty amplifier operating at gigahertz frequencies are described. The combining of signals from a main amplifier and a peaking amplifier occur prior to impedance matching of the amplifier's output to a load. An integrated distributed inductor may be used in an impedance inverter to combine the signals. A size of the impedance element can be selected by patterning during manufacture to tune the amplifier and to allow power scaling for the amplifier.

Abstract: The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3? end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Abstract: A multi-voltage converter is described that includes integrated temperature-protection circuity. The converter may be used to bias radio-frequency components such as PIN diodes and gallium-nitride devices, and may include integrated bias-sequencing circuitry. Programmable output voltages as high as 30 volts and as low as ?20 volts may be generated.

Abstract: The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions comprising a RNAi agent having a novel format: an 18-mer format with at least one internal spacer. These RNAi agents comprise a first and a second 18-mer strand, wherein the first strand is 18 ribonucleotides or 18 total ribonucleotides and spacer subunit(s), and the second strand is 18 total ribonucleotides and spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand; the two strands form a duplex with at least one blunt end; and the 3 end of one or both strands terminates in a phosphate or modified internucleoside linker and further comprises, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker, and a 3 end cap.

Abstract: The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3? end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Abstract: A wagering platform is described that generates one or more betting options and/or insurance to enable a bettor to modify his initial wager during a betting event such as, for example, a sporting event. The options can include, for example, allowing the bettor to double-down, to flip-flop, and/or to purchase bad-beat insurance. The platform can also include a locked-odds option to allow the bettor the option to place a wager at specified odds after the event has already started. Related apparatus, systems, techniques and articles are also described.

Abstract: The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions comprising a RNAi agent having a novel format: an 18-mer format with at least one internal spacer. These RNAi agents comprise a first and a second 18-mer strand, wherein the first strand is 18 ribonucleotides or 18 total ribonucleotides and spacer subunit(s), and the second strand is 18 total ribonucleotides and spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand; the two strands form a duplex with at least one blunt end; and the 3 end of one or both strands terminates in a phosphate or modified internucleoside linker and further comprises, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker, and a 3 end cap.

Abstract: The disclosure relates to compositions comprising a HBV RNAi agent. In some embodiments, the HBV RNAi agent comprises a sense and an anti-sense strand, each strand being an 18-mer and the strands together forming a blunt-ended duplex, wherein the 3? end of at least one strand terminates in a phosphate or modified internucleoside linker and further comprises, in 5? to 3? order: a spacer; a second phosphate or modified internucleoside linker; and a 3? end cap. In some embodiments, the 3? end of both the sense and anti-sense strand further comprise, in 5? to 3? order: a spacer; a second phosphate or modified internucleoside linker; and a 3? end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3? end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker.

Abstract: A data distribution system is provided which supplies customers with an executable for requested secured data files to provide the customer with fulfillment software, obviating the need for the customer to download fulfillment software prior to requesting secure data. The data distribution system is characterized by server technology which can dynamically encrypt secured data files just prior to a customer request to download the data file. A framework for building a universal data distribution infrastructure is provided which employs Requesters.

Abstract: A system and method for making snapshots of storage devices are provided. A method for making a snapshot of a volume includes setting the volume to a read-only mode, receiving an access attempt for the volume, and if the access attempt is a write access attempt, buffering information associated with the write access attempt in a buffer, and updating a snapshot indicator based on the information associated with the write access attempt, where the snapshot indicator includes block information regarding a block in the volume that is a target of the write access attempt. The method also includes if the access attempt is a read access attempt, providing read information requested in the read access attempt, where the read information is based on the volume, or a combination of the snapshot indicator, the buffer, and a buffer indicator.

Abstract: A method for enabling raster image editing software to work with geospatial imagery includes identifying geospatial metadata for an image upon opening of the image, and monitoring all raster image editing operations performed on the image to determine if the geospatial metadata is affected. The geospatial metadata is updated if the geospatial metadata is affected by a raster image editing operation. In another aspect, a computer readable medium contains instructions for controlling a computer system to perform a method for enabling raster image editing software to work with geospatial imagery.