Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The present disclosure provides improved compositions for the homology directed repair of the human globin locus for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.

Abstract: A load control system for controlling an electrical load may include a sensor, a remote control, and a load control device. The remote control may comprise a button and may be configured to wirelessly transmit a digital message in response to an actuation of the button. The load control device may be configured to control the electrical load, be responsive to the sensor, and/or be configured to be associated with the remote control. The load control device may be responsive to the digital message transmitted by the remote control if the remote control is associated with the load control device. The load control device may be configured to automatically operate in a first mode of operation if the remote control is not associated with the load control device, and automatically operate in a second mode of operation if the remote control is associated with the load control device.

Abstract: A method and system are provided for validating process data on a process recorder/controller. The method and system involves: configuring the validation criteria of the process variables, by defining value and time tolerances with respect to an ideal performance; receiving in real-time process data, including one or more process values, for a batch process at the recorder/controller responsible for recording the process data; performing a batch validation process on the recorder/controller, the batch validation process analyzing in real-time the one or more process values to validate the batch process based on at least a batch validation criteria; and transmitting from the recorder/controller validation information including a validation result for presentation on a device to a user, and/or recording at least on the recorder/controller the validation information including at least the validation result, wherein the validation result indicates whether the batch process is conformant or non-conformant.

Abstract: An implant system for implantation at a joint. The implant system includes an implant device with a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion. The implant system has a corresponding fixation device with at least one latching element. The first elongate member has at least one cooperating element capable of cooperating with the at least one latching element of the fixation device in use.

Abstract: Systems, methods, and catheters for endovascular treatment of a blood vessel are disclosed. In one aspect, a catheter for endovascular treatment of a blood vessel. The catheter comprises a housing. The catheter further comprises a treatment portion. The catheter further comprises a fistula forming element. And the catheter further comprises an intravascular ultrasound imaging device.

Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: Wireless base stations and operating methods therefor are disclosed, where the wireless base station is configured for wireless communication with a plurality of terminals and comprises an antenna array to generate a plural beams. A scheduler allocates wireless resources comprising the plural beams and plural resource block groups. The wireless resource allocation for a given timeslot comprises an initial and an iterative stage, the initial stage comprising: selecting a first beam for allocation to a first terminal and determining a first selected subset of RBGs that satisfy a channel quality threshold. The iterative stage comprises selecting a further beam for allocation to a further terminal and determining a candidate subset of RBGs that each do not have expected interference above an interference tolerance threshold for any already-allocated resource. From this subset an allocation is made to satisfy a channel quality threshold. The iterative stage is repeated as required.

Abstract: An apparatus and method are provided for performing a handover analysis. The apparatus comprises base station location identifying circuitry to obtain base station location information for a plurality of base stations that provide a wireless network for communication with a moving vehicle. In addition, moving vehicle tracking circuitry is provided to obtain position and velocity information for the moving vehicle. Handover metrics computation circuitry is then used to generate at least one handover metric computed from the position and velocity information for the moving vehicle and the base station location information, for use in determining a target base station in said plurality to be used when performing a handover procedure to transition communication with the moving vehicle from the current base station in said plurality to the target base station.

Abstract: Systems and methods for minimally invasive procedures include a computer-assisted system comprising a manipulator assembly configured to couple to a cannula and a controller coupled to the manipulator assembly. The cannula has a lumen configured to receive a shaft of an instrument. The controller is configured to position a remote center of motion for the manipulator assembly at a first location relative to the cannula, and in response to an indication to reposition the remote center of motion relative to the cannula, reposition the remote center of motion to a second location relative to the cannula while constraining the second location to be located along the cannula. The second location is different from the first location.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A vertical farming structure having vertical grow towers and associated conveyance mechanisms for moving the vertical grow towers through a controlled environment, while being exposed to controlled conditions, such as lighting, airflow, humidity and nutritional support. The present disclosure describes a reciprocating cam mechanism that provides a cost-efficient mechanism for conveying vertical grow towers in the controlled environment. The reciprocating cam mechanism can be arranged to increase the spacing of the grow towers as they are conveyed through the controlled environment to index the crops growing on the towers. The present disclosure also describes a tower shuttle mechanism that provides operational flexibility by decoupling the loading and unloading operations of the grow towers from the vertical farming structure and, therefore, allowing multiple grow towers to be extracted for harvesting in a batch process before loading new grow towers into the vertical farming structure in a separate process.

Abstract: Aspects of the invention include receiving, at an operating system executing on a processor, a write request from a program to write data to a memory. The write request includes a virtual memory address and the data. It is determined that the virtual memory address is not assigned to a physical memory address. Based on the determining, the unassigned virtual memory address is assigned to a physical memory address in an overflow memory. The data is written to the physical memory address in the overflow memory and an indication that the write data was successfully written is returned to the program. Future requests by the program to access the virtual memory address are directed to the physical memory address in the overflow memory.

Abstract: A resin composition comprises a prepolymer, a reactive diluent, and optionally a crosslinker, wherein the reactive diluent has an absorption maximum (Amax) or excitation maximum (Amax) of between 350 and 520 nm for example in acetone and at pH 7.

Abstract: A pin for a pinned joint includes a hollow body with a first and second end caps coupled to first and second ends, respectively. The body and the end caps at least partially define a cavity within the body, wherein at least one aperture extends through the hollow body. A main piston is slidably disposed within the cavity and divides the cavity into a first chamber proximate to the first end and a second chamber proximate to the second end and fluidly isolated from an environment around the body. A lubricant is disposed within the first chamber. The main piston moves toward the first end of the body when a pressure in the second chamber is greater than a pressure of the environment. Movement of the main piston toward the first end of the body discharges lubricant through the at least one aperture.

Abstract: Facility layouts and configurations for an automated crop production system for controlled environment agriculture. In particular implementations, the core of the facility comprises a controlled growth environment and a central processing system. The controlled growth environment includes systems for exposing crops housed in modules, such as grow towers, to controlled environmental conditions. The central processing system may include various stations and functionality both for preparing crop-bearing modules to be inserted in the controlled growth environment, for harvesting crops from the crop-bearing modules after they have been extracted from the controlled growth environment, and for cleaning or washing crop-bearing modules for re-use. The controlled growth environment may include vertical farming structure having vertical grow towers and associated conveyance mechanisms for moving the vertical grow towers along one or more grow lines.

Abstract: An automated checkout system aims to detect and disable certain functionalities of an auto-checkout client application if a user exhibits anomalous behavior. The system collects user interaction data to describe the user's interactions with the client device through the application. It then uses a behavior scoring model on the data to generate an anomalous behavior score, indicating the likelihood of anomalous behavior. For instance, if a user scans an item far from its usual location, the score may suggest atypical behavior. The system employs the behavior score to identify functionalities to disable by comparing it to a set of threshold values. Each threshold corresponds to specific auto-checkout application functionalities to be disabled if the behavior score reaches the thresholds. For example, if a threshold is related to identifying items by image capture, the system may disable this feature if the score exceeds the threshold value.

Abstract: A privacy glazing structure may include an electrically controllable optically active material that provides controlled transition between a privacy or scattering state and a visible or transmittance state. To make electrical connections with electrode layers that control the optically active material, the privacy glazing structure may include electrode engagement regions. In some examples, the electrode engagement regions are formed as notches in peripheral edges of opposed panes bounding the optically active material. The notches may or may not overlap to provide a through conduit in the region of overlap for wiring. In either case, the notches may allow the remainder of the structure to have a flush edge surface for ease of downstream processing.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material included in a consumable, the non-combustible aerosol provision device having: a receptacle for receiving the consumable; and an adaptor configured to adapt the non-combustible aerosol provision device by varying an effective length of the receptacle such that each of a plurality consumables of different lengths, which are individually receivable in the receptacle, when received in the receptacle for use, protrude from the non-combustible aerosol provision device by substantially equal amounts.