Abstract: A method of manufacturing a ceramic tape includes advancing a tape through a binder burn-off station, where the tape entering the binder burn-off station comprises grains of polycrystalline ceramic bound by an organic binder. The binder burn-off station comprises an active heater that chemically changes the organic binder and/or removes the organic binder from the tape, leaving the tape with the grains of the polycrystalline ceramic exiting the binder burn-off station.

Abstract: Systems, methods, and devices for disinfecting tonometer probes are described. One example provides a specialized container that allows easy catching of a used probe without having to touch the probe, allows for the storage of multiple used probes, allows for simple disinfection of the probes without having to handle the probes or remove them from the container, allows for rinsing of the probes and container without handling the probes, and then allows for the simple insertion of the disinfected probes directly from the container without having to touch the probes or reinsert them into their specialized tubes.

Abstract: A wayfinding application executing on a client device receives a current location of the device within a warehouse and accesses a layout of the warehouse describing locations of items included among an inventory of the warehouse. The application identifies a route from the current location to one or more locations within the warehouse associated with one or more target items, generates augmented reality elements including instructions for navigating the route, and sends the elements to a display area of the device. The application detects a location within the warehouse associated with a target item and determines whether the item is at the location based on an image captured by the device. Upon determining it is not at the location, the application alerts a user of the device to a replacement item by generating an augmented reality element that calls attention to it and sending the element to the display area.

Abstract: Provided herein are ATXN2 RNAi agents and compositions comprising an ATXN2 RNAi agent. Also provided herein are methods of using the ATXN2 RNAi agents or compositions comprising an ATXN2 RNAi agent for reducing ATXN2 expression, and/or treating ATXN2-associated neurological disease in a subject.

Abstract: A multilayer film and a pouch made therefrom is disclosed. The film having an ethylene-vinyl alcohol copolymer-based barrier layer and an outer layer made from at least 95 wt % of a branched ethylene copolymer. The branched ethylene copolymer being 50 mol % or more ethylene, 50 mol % or less of a C6 to C8 alpha-olefin comonomer, and at least 0.001 mol % of a remnant of a metal hydrocarbyl chain transfer agent. The film including substrate layers between the barrier layer and each outer layer. The film having low oxygen transmission rate and a low a moisture transmission rate.

Abstract: Conducting user research with human users is time consuming and expensive. Provided with quality training data that represents human users having different personae, models can be trained to offer responses that can emulate different human users. The models may offer synthetic users that can extract information from and respond to inputs to the models. The inputs can include prompts and responses can include answers to the prompts. In some cases, data about human users can be used to build different synthetic user memories, which may be used to generate different prompt chains corresponding to different users. The prompt chain can be used to prompt a model to respond based on the contextual information in the synthetic user memory.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: A method is described and includes presenting a stimulus to a user, wherein the stimulus comprises at least a portion of a first item of content and includes audio, video, or both; detecting at least one non-verbal reaction of the user to the stimulus; processing the detected at least one non-verbal reaction to determine a response of the user to the stimulus; providing to the user a list of recommendations based on the determined response of the user to the stimulus, wherein the list of recommendations comprises at least one second item of content selected from a content database; and prompting the user to select an item of content from the list of recommendations.

Abstract: A load control system controls an electrical load provided in a space and comprises a load control device and one or more occupancy sensors. The load control device controls the load in response to the wireless control signals received from the occupancy sensors. Each occupancy sensor transmits an occupied control signal to the load control device in response to detecting an occupancy condition in the space and a vacant control signal to the load control device in response to detecting a vacancy condition. The load control device turns on the load in response to receiving the occupied control signal from at least one of the occupancy sensors, and turns off the load in response to receiving vacant control signals from both of the occupancy sensors. The load control device is operable to determine that no wireless control signals have been received from the occupancy sensors for the length of a predetermined timeout period and to subsequently turn off the load.

Abstract: In one aspect, disclosed is an example method for use in connection with a media-presentation device presenting a media program via a display screen of the media-presentation device, the method including: (i) during presentation of a temporal portion of the media program, identifying an audience engagement region of presented content, wherein the identified audience engagement region is less than an entirety of a display area that corresponds to the display screen; (ii) using at least the identified audience engagement region as a basis to select a media segment from among multiple candidate media segments; (iii) identifying an upcoming media segment insertion point within the media program; and (iv) facilitating the media-presentation device inserting, at the identified media segment insertion point within the media program, the selected media segment.

Abstract: Camera equipment used for capturing a live event is expensive and may require professionals to operate the equipment. Such camera equipment is not accessible for capturing events and experiences by everyday users. Suppose media content is captured by lower-cost input devices such as mobile phones with a video camera. A production platform can use computer vision techniques to produce enhanced media content from media content captured by the lower-cost input devices. In one example, the production platform can aggregate and analyze the received media content to extract information and determine blind spots. The production platform can create or retrieve content based on the extracted information and insert the content in the blind spots. The production platform can deliver enhanced media content to an end user device, the enhanced media content may have the received media content and the inserted content.

Abstract: A safety assembly for use with a laser-directed energy weapon is disclosed. The assembly comprises a control system comprising a photodetector and a processing unit; and an optical device configured to attach to a target such that, when attached, the optical device provides a light beam to the photodetector. The processing unit is arranged to compare the received light beam against one or more predetermined attributes, and to permit the laser-directed energy weapon to fire only when the received light beam is determined to have the one or more attributes.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Abstract: The present invention relates to a microfluidic assay system and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using a disposable system and associated reading device, as well as kits for conducting assays.

Abstract: The invention relates to an indane compound according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, n and p are as defined herein. The compounds are useful for treating antibacterial infection either as stand-alone antibiotics, or in combination with further antibiotics.

Abstract: Providing policy check functionality to file uploads is disclosed. An attempted file upload is detected at a browser isolation system. A user of a client is prompted to provide a credential associated with the file and usable to access contents of the file. A policy is applied to the file upload.

Abstract: Articles including a substrate, a cover glass layer disposed over a top surface of the substrate, and an adhesive layer having a dynamic elastic modulus disposed between a bottom surface of the cover glass layer and the top surface of the substrate. The cover glass layer may have a thickness in the range of 1 micron to 200 microns. The dynamic elastic modulus of the adhesive layer may include a first elastic modulus in the range of 10 kPa to 1000 kPa measured at a stress frequency in the range of 0 Hertz to 5 Hertz and a temperature of 23 degrees C., and a second elastic modulus of 500 MPa or more measured at a stress frequency in the range of 10 Hertz to 1000 Hertz and a temperature of 23 degrees C. The adhesive layer may be optically transparent. The articles may be bendable electronic display devices or bendable electronic display device modules.

Abstract: The present disclosure pertains to a system and method for determining differences between at least two documents. A preferred embodiment disclosed herein pertains to a system and method for determining differences in the text or terms of legal documents, for example transactional legal agreements, such as but not limited to Trade Confirmations. The document review system can compare text documents to other text documents but is further capable of comparing text documents to structured spreadsheet data. The combination of static component verification in combination with dynamic component verification leads to a powerful tool which greatly reduces the time and efficient of document review while reducing the risk of human errors. Utilizing word embeddings in the static verification in combination with the use of named entity recognition, rule parsers in the dynamic verification, enables the system to produce concise and meaningful summaries of differences between multiple documents.

Abstract: Systems and methods for extending an original bit length counter maintained by hardware of a network device to generate an extended length timestamp of a longer bit length are disclosed. The extension of the original bit length counter is based on a rollover counter, where the rollover counter is incremented based on the detection of rollovers of the original bit length counter.