Abstract: The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.

Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.

Abstract: Feeds in a network-based marketplace are described. The system receives a request, over a network, from a user that is associated with feed selection information, and identifies source feeds based on the feed selection information. The source feeds respectively include a first plurality of content elements. The system generates a presentation feed by retrieving a second plurality of content elements from the source feeds. The generating is performed continuously and in real-time. The system segments the presentation feed into pages and generates interfaces that include a first interface based on the pages. The system communicates the first interface, over the network, to the user, responsive to the receiving of the request.

Abstract: An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

Abstract: The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising a polycation with multiple pendant metal-chelating side-chains. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.

Abstract: Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.

Abstract: A fuel cell system includes a hotbox configured to house a fuel cell stack, the fuel cell stack including a temperature sensor configured to detect temperature inside the fuel cell stack. The system includes a first tank including a first valve and configured to store methanol. The system includes a second tank including a second valve and configured to store water. The system includes a controller communicatively coupled to receive signals from the temperature sensor and control each of the first valve and the second valve. The controller is configured to set a dosing rate of methanol, based on a temperature of the fuel cells stack, to a predefined dosing rate and initiate operating at least one of the first valve and the second valve to deliver a mixture of methanol and water at the predefined dosing rate to prevent re-oxidation of an anode of the fuel cell stack.

Abstract: A framework for power management. The framework includes at least one power distribution board disposed within a radio-frequency (RF) cabin of a medical imaging system and coupled to an external reference clock. The power distribution board may include a clock circuit that generates one or more output clock signals based on a reference clock signal from the external reference clock. One or more switching regulators may be coupled to the clock circuit. The one or more switching regulators may be synchronized to the one or more output clock signals and provide power to one or more endpoint loads.

Abstract: A composition of matter is generally provided, in one embodiment, a titanium alloy comprising about 5 wt % to about 8 wt % aluminum; about 2.5 wt % to about 5.5 wt % vanadium; about 0.1 wt % to about 2 wt % of one or more elements selected from the group consisting of iron and molybdenum; about 0.01 wt % to about 0.2 wt % carbon; up to about 0.3 wt % oxygen; silicon and copper; and titanium. A turbine component is also generally provided, in one embodiment, that comprises an article made from a titanium alloy. Additionally, methods are also generally provided for making an alloy component having a beta transus temperature and a titanium silicide solvus temperature.

Abstract: Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.

Abstract: The invention provides a surfactant system, for use in household detergent compositions, which is a mixture of: (i) at least one sulfonate-functionalized alkyl polyglycoside of general formula (I): R—O-(G)n-(D)??(I) in which: R represents a straight or branched chain monovalent hydrocarbyl radical having from 6 to 22 carbon atoms; G represents a residue of a reducing saccharide, connected to R—O by means of an ethereal O-glycosidic bond; n represents a number from 1 to 10; and D represents a —CH2CH(OH)CH2—SO3M group connected to an oxygen atom of G, where M is selected from H or a monovalent cation selected from Na, K, or NH4; and (ii) at least one ethoxylated fatty acid sorbitan ester of general formula (II): Sorb-(EOn1R1)(EOn2R2)(EOn3R3)(EOn4R4)??(II) in which: Sorb represents a residue obtained by removing four hydroxyl H atoms from sorbitan; EO represents an ethyleneoxy group; R1, R2, R3 and R4 are each independently selected from H or a —C(O)R5 group in which R5 is selected from straight or b

Abstract: A downhole tool comprises a hollow body having a wall and a port in the wall, and a closing sleeve movable relative to the body to open and close the port. A seal is provided between the body and the sleeve and is configured to hold differential pressure. An isolation member may be deployed in the tool to isolate the seal from differential pressure and close the port. The isolation member may be deployed following initiation of a tool activation process, a successful outcome of the process being translating the closing sleeve and closing the port, and positioning the seal to hold a differential pressure. If it is detected that the outcome has not been achieved, the isolation member is deployed to isolate the seal from differential pressure and close the port.

Abstract: Disclosed is a method of determining call quality for a contact centre. A call is initialised between a customer agent and a contact centre agent, with the customer agent connecting to the call at a point of presence having a selectable geographic location. Monitoring information is received, for the call, measured at the customer agent, the contact centre agent and a contact centre service provider connecting the call between the customer agent and the contact centre agent. Quality of the call is determined from the monitoring information collected from the customer agent, the contact centre agent and the contact centre service provider.

Abstract: A method of quantifying the removal of hydrocarbon component from a soiled fabric by a washing process, wherein the soiled fabric includes at least about 0.5 wt % hydrocarbon component wherein the method uses near infra-red (NIR) analysis, wherein the method includes the steps of: (a) performing non-contact NIR analysis of the soiled fabric to determine the concentration of hydrocarbon component present on the soiled fabric at multiple points; (b) washing the soiled fabric to obtain a washed fabric; (c) performing non-contact NIR analysis of the washed fabric to determine the concentration of hydrocarbon component present on the washed fabric at the same multiple points that were used in step (a); and (d) quantifying the removal of hydrocarbon component from the soiled fabric by the washing process.

Abstract: Embodiments described herein provide for the dynamic adjustment of traffic associated with audiovisual conferences or other types of communication sessions in situations where a network connection of one or more conference participants exhibits issues that may affect audio and/or video quality. The adjustment may include the determination at a particular conference participant (e.g., a particular User Equipment (“UE”)) of degraded network conditions, the generation of condensed conference information at the UE, and the outputting of the condensed conference information via the network. The condensed conference information may be included in control signaling. The condensed conference information may be used to generate reconstructed conference information, which may be distributed to other conference participants.

Abstract: A fuel cell power system and method for identifying and compensating for variations identified in a fuel composition of a fuel cell power system, comprising the fuel cell system components selected from the group consisting of a catalytic oxidizer, a reformer, an exhaust, a fuel cell stack or system, or a combination thereof; and a control device configured to control the fuel cell system components, wherein the control device comprises a computer algorithm to indirectly correlate measurements of the fuel cell system components to a difference in the fuel composition.

Abstract: The present invention relates to mixtures of serine or threonine together with at least one further amino acid or amino acid derivative and with at least one calcium salt or its hydrate and methods including this mixture including specific mixtures of such components and a formulations consisting of the mixture and a solvent.

Abstract: Methods and computing devices for matching an instrument to a device-under-test for performing a test procedure. A first data structure is constructed based on a data sheet of an instrument. The first data structure includes attributes, phenomena to be measured and testing interactions for measuring respective phenomena. A test case is constructed based on a test procedure to be performed on the DUT. The test case includes attributes, phenomena to be measured and testing interactions for measuring respective phenomena. The attributes, phenomena, and testing interactions of the first data structure and the test case are compared to determine a matching condition, and instructions are output based on the matching condition.

Abstract: The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of extracellular histones in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating extracellular histone mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRO). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of extracellular histone mediated ailments. For example, the present invention relates to methods and uses of ?-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g.

Abstract: Embodiments described herein provide for the dynamic adjustment of traffic associated with audiovisual conferences or other types of communication sessions in situations where a network connection of one or more conference participants exhibits issues that may affect audio and/or video quality. The adjustment may include the determination at a particular conference participant (e.g., a particular User Equipment (“UE”)) of degraded network conditions, the generation of condensed conference information at the UE, and the outputting of the condensed conference information via the network. The condensed conference information may be included in control signaling. The condensed conference information may be used to generate reconstructed conference information, which may be distributed to other conference participants.