Abstract: A structural building system and method for forming and using a structural element at a building site using a structural mix comprised of an aggregate material sourced exclusively from the building site, a no-bake binder, and a strengthening additive. According to the method disclosed herein, aggregate material is sourced exclusively from a supply of aggregate material located at a building site. A no-bake binder is combined with the aggregate material in a mixer to form a structural mix at the building site. Finally, the structural mix is deposited at a deposit site and is allowed to self-harden to form a structural element.

Abstract: The present invention provides a thermocycling method for increasing the number of tandem repeats of a unit sequence that is 1 to 60 nucleotides long in a linear polynucleotide. The invention also provides a solid substrate with a surface, the surface having at least one linear probe polynucleotide immobilised thereon, wherein the at least one linear probe polynucleotide comprises at least two tandem repeats of a unit sequence that is 1 to 60 nucleotides long. Methods of determining the presence of a linear target polynucleotide sequence in a test sample using such solid substrates are also provided.

Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.

Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.

Abstract: The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (0): or a salt or tautomers or N-oxides or solvate thereof; wherein X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alk

Abstract: The present invention provides the use of fused pyrrole carboxylic acids of formula (I) for the manufacture of a medicament to inhibit D-amino acid oxidase, particularly for the treatment of neurodegenerative and psychiatric disorders or diseases; certain compounds of formula I being novel, pharmaceutical compositions containing them, their use in medicine and methods of treatment using them are also disclosed.

Abstract: The invention provides a method of predicting output values of a physical system from a set of measured inputs of the system using an adaptive model. At each time when a prediction is made, the model is re-initialized to an initial, off-line model and is then refined to incorporate on-line data using a predetermined number of recent sets of measured inputs and outputs. The model thus always remains “tethered” to the initial, off-line model and if operating conditions remain steady, the model does not become too specific to those operating conditions.