Abstract: According to an example aspect of the present disclosure, there is provided an apparatus comprising means for receiving, from a service network function, a request related to charging for a user equipment, means for determining whether to defer a consensus-based charging operation associated with the user equipment, means for transmitting to the service network function, when it is determined that the consensus-based charging operation is to be deferred, an indication indicating that the request is granted and means for refraining from transmitting any indication about the consensus-based charging associated with the user equipment until it is determined that the consensus-based charging operation associated with the user equipment is not to be deferred.

Abstract: The present invention relates to the formation of multi-domain specific binding molecules comprising VNARs. Specific binding domains that bind to Tumour Necrosis Factor alpha (TNF?) are also provided.

Abstract: The present invention relates to receptor tyrosine kinase-like orphan receptor I (RORI) specific antigen binding molecules and associated fusion proteins and conjugates. In a further aspect, the present invention relates to coajugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: The present invention relates to the formation of multi-domain specific binding molecules comprising VNARs. Specific binding domains that bind to Tumour Necrosis Factor alpha (TNF?) are also provided.

Abstract: The present invention relates to receptor tyrosine kinase-like orphan receptor 1 (ROR1) specific antigen binding molecules and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: Provided are methods for identifying surface-exposed epitopes of fungal cell wall proteins, and related peptide antigens, suitable for the development of antifungal antibodies. The methods allow for the detection of surface-exposed epitopes that are particularly highly expressed in drug-resistant fungal pathogens, and in pathogens exposed to antifungal drugs. Also provided are antifungal antibodies which may be derived by these methods. The methods and antibodies find use in the treatment of treating and diagnosing fungal infections, such as candidiasis, aspergillosis cryptococcosis, and Mucormycosis.

Abstract: The present invention relates to the formation of multi-domain specific binding molecules comprising VNARs. Specific binding domains that bind to Tumour Necrosis Factor alpha (TNF?) are also provided.

Abstract: The present invention relates to the formation of multi-domain specific binding molecules comprising VNARs. Specific binding domains that bind to Tumour Necrosis Factor alpha (TNF?) are also provided.

Abstract: According to an example aspect of the present disclosure, there is provided an apparatus comprising means for receiving, from a service network function, a request related to charging for a user equipment, means for determining whether to defer a consensus-based charging operation associated with the user equipment, means for transmitting to the service network function, when it is determined that the consensus-based charging operation is to be deferred, an indication indicating that the request is granted and means for refraining from transmitting any indication about the consensus-based charging associated with the user equipment until it is determined that the consensus-based charging operation associated with the user equipment is not to be deferred.

Abstract: The present invention relates to receptor tyrosine kinase-like orphan receptor 1 (ROR1) specific antigen binding molecules and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: The present invention relates to bi-specific antigen binding molecules and associated fusion proteins and conjugates. In particular, the present invention relates to bi-specific antigen binding molecules with specificity for both receptor tyrosine kinase-like orphan receptor 1 (ROR1) and epidermal growth factor receptor (EGFR) and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: The present invention relates to the formation of multi-domain specific binding molecules comprising VNARs. Specific binding domains that bind to Tumour Necrosis Factor alpha (TNF?) are also provided.

Abstract: A fault-tolerant failsafe computer voting system including a first voting module that generates a first key based on a comparison between a first data packet and a copy of a second data packet. The first voting module determines whether the first key and a second key are valid keys. The second data packet is a copy of the first data packet. A second voting module generates the second key based on a comparison between the second data packet and a copy of the first data packet. A processing module generates an outgoing data packet based on the first data packet in response to determining whether the first key and the second key are valid keys. The first voting module is inhibited from generating the second key and the second voting module is inhibited from generating the first key.

Abstract: A system includes a first fail-safe chassis (FSC) receives module health signals from a plurality of modules and generates a first chassis health signal. The chassis health signal includes first and second portions. A plurality of modules receives the chassis health signal. The FSC determines whether one or more of the module heals signals indicates an associated module is unhealthy by comparing the module health signals and a predetermined health value. The FSC selectively de-asserts the first chassis health signal based on the comparison. A second FSC operates similarly. A safety relay box determines the health of the system in accordance with the first and second chassis health signals.

Abstract: A fault-tolerant failsafe computer voting system including a first voting module that generates a first key based on a comparison between a first data packet and a copy of a second data packet. The first voting module determines whether the first key and a second key are valid keys. The second data packet is a copy of the first data packet. A second voting module generates the second key based on a comparison between the second data packet and a copy of the first data packet. A processing module generates an outgoing data packet based on the first data packet in response to determining whether the first key and the second key are valid keys. The first voting module is inhibited from generating the second key and the second voting module is inhibited from generating the first key.

Abstract: A system includes a first fail-safe chassis (FSC) receives module health signals from a plurality of modules and generates a first chassis health signal. The chassis health signal includes first and second portions. A plurality of modules receives the chassis health signal. The FSC determines whether one or more of the module heals signals indicates an associated module is unhealthy by comparing the module health signals and a predetermined health value. The FSC selectively de-asserts the first chassis health signal based on the comparison. A second FSC operates similarly. A safety relay box determines the health of the system in accordance with the first and second chassis health signals.

Abstract: A cover for the deck of a utility vehicle may be formed from a single shell of thermoplastics material and reinforced with an extrusion that, by virtue of being formed in aluminum or another suitable material, has a lower co-efficient of expansion relative to the shell. The two parts of the cover, shell and extrusion, may be secured in such a way that there can be some degree of independent movement between them. Effectively, limited thermal expansion of the shell is allowed without overly compromising the connection between it and the aluminum extrusion. A flexible extrusion may connect the cover to the utility vehicle at one end and act as a hinge such that as it is raised, it is not only displaced in a vertical orientation, but also in a horizontal direction.

Abstract: A cover for the deck of a utility vehicle may be formed from a single shell of thermoplastics material and reinforced with an extrusion that, by virtue of being formed in aluminum or another suitable material, has a lower co-efficient of expansion relative to the shell. The two parts of the cover, shell and extrusion, may be secured in such a way that there can be some degree of independent movement between them. Effectively, limited thermal expansion of the shell is allowed without overly compromising the connection between it and the aluminum extrusion. A flexible extrusion may connect the cover to the utility vehicle at one end and act as a hinge such that as it is raised, it is not only displaced in a vertical orientation, but also in a horizontal direction.

Abstract: A process for the production of an antigen specific antigen binding domain using a transformed host containing an expressible DNA sequence encoding the antigen specific antigen binding domain, wherein the antigen specific antigen binding domain is derived from a variable region of the immunoglobulin isotype NAR found in fish.

Abstract: A computerized reel-based game system including an array of indicators ordered by random or pseudorandom spin of reels; a processor applying rules to the location of the indicators to determine an outcome category corresponding to the particular array; a user interface enabling user-initiated positioning of overlay indicator/s at a selectable position in the array; a lock unit for, responsive to an actuation command, replacing an indicator to be positioned in the selected position resulting from a next spin by said overlay indicator/s, the processor applying the rules to the resultant array with said overlay indicator in the selected position; an actuation module computing, responsive to said user-initiated positioning of the overlay indicator, a stake paid according to the selected position and a cost associated therewith, to enable presenting the associated cost and, responsive to user's approval of the stake, generating said actuation command and sending it to the lock unit.