Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

Abstract: A connector (1) for connecting a drainage bag (19) around a fistula (23) of a subject, comprising an elongate flexible tubular member (3) having an inlet aperture (5) for receiving waste material from a fistula (23) and an outlet aperture (7) for engagement with a drainage bag (19) through which waste material travels before entering the drainage bag (19). There is also described a drainage appliance incorporating such a connector.

Abstract: Magnetic resonance images are acquired by combining images obtained using two different spatial sensitivity profiles, 1?, 2?. The transverse magnetisation is caused to adopt such a profile 1? in one direction, resulting, in two dimensions, to a series of alternating stripes of respectively strong and weak, e.g. zero, transverse magnetisation. The regions of strong transverse magnetisation correspond to regions of high sensitivity in the acquired image. A complementary sensitivity profile 2? is stored as longitudinal magnetisation. A first image is then acquired in which the pixels are centered on the regions of high sensitivity within the first sensitivity profile 1?. The complementary sensitivity profile 2? is then recalled by inserting an additional gradient pulse and then a radio-frequency pulse into the pulse sequence and a second image acquired. As with the first image, the pixels are centered on the high-sensitivity regions, but these are mid-way between those within the first sensitivity profile 1?.