Patents by Inventor Andrew R.M. Bradbury

Andrew R.M. Bradbury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phage-Displayed Accessible Recombinant Targeted Antibodies and Methods of Making Same
    Publication number: 20230139913
    Abstract: Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
    Type: Application
    Filed: October 18, 2022
    Publication date: May 4, 2023
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda Iamassaki Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R.M. Bradbury
  • TANDEM CD19 CAR-BASED COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20230092895
    Abstract: The present invention provides biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 23, 2023
    Inventors: Vipin Suri, Michael Joseph Briskin, Brian Dolinski, Kutlu Goksu Elpek, Tucker Ezell, Scott Francis Heller, Mara Christine Inniss, Tariq A. Kassum, Nicole Kosmider, Abhishek Kulkarni, Meghan Langley, Dan Jun Li, Michelle Lynn Ols, Benjamin J. Primack, Celeste Richardson, Steven Mark Shamah, James Storer, Dexue Sun, Vijaya Balakrishnan, Andrew R.M. Bradbury, Michael Frank Erasmus, Fortunato Ferrara
  • GRP78-BINDING ANTIBODIES AND USES THEREOF AND SELECTION OF PHAGE-DISPLAYED ACCESSIBLE RECOMBINANT TARGETED ANTIBODIES
    Publication number: 20230028927
    Abstract: Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
    Type: Application
    Filed: June 10, 2022
    Publication date: January 26, 2023
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda Iamassaki Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R.M. Bradbury
  • GRP78-BINDING ANTIBODIES AND USES THEREOF AND SELECTION OF PHAGE-DISPLAYED ACCESSIBLE RECOMBINANT TARGETED ANTIBODIES
    Publication number: 20220348680
    Abstract: Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
    Type: Application
    Filed: June 10, 2022
    Publication date: November 3, 2022
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda Iamassaki Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R.M. Bradbury
  • GRP78-BINDING ANTIBODIES AND USES THEREOF AND SELECTION OF PHAGE-DISPLAYED ACCESSIBLE RECOMBINANT TARGETED ANTIBODIES
    Publication number: 20220306763
    Abstract: Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
    Type: Application
    Filed: February 4, 2022
    Publication date: September 29, 2022
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda Iamassaki Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R.M. Bradbury
  • EphA5-binding antibodies and uses thereof and selection of phage-displayed accessible recombinant targeted antibodies
    Patent number: 11254751
    Abstract: Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: February 22, 2022
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Renata Pasqualini, Wadih Arap, Fernanda Iamassaki Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R. M. Bradbury
  • EphA5- AND GRP78 BINDING ANTIBODIES AND USES THEREOF AND SELECTION OF PHAGE-DISPLAYED ACCESSIBLE RECOMBINANT TARGETED ANTIBODIES
    Publication number: 20190202922
    Abstract: Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vim methodologies is also provided.
    Type: Application
    Filed: September 21, 2017
    Publication date: July 4, 2019
    Inventors: RENATA PASQUALINI, WADIH ARAP, FERNANDA IAMASSAKA STAQUICINI, FORTUNATO FERRARA, ANDREW R.M. BRADBURY
  • GENETICALLY ENGINEERED POLYMER LIBRARIES AND METHODS OF USING THEM
    Publication number: 20170029812
    Abstract: Disclosed herein are methods of identifying polymers having particular biological or physical characteristics from in vivo generated libraries of polymers. Methods of generating in vivo polymer libraries are also described. Polymers identified using the methods of the invention are also described.
    Type: Application
    Filed: January 28, 2015
    Publication date: February 2, 2017
    Inventors: Jennifer S. Martinez, Devin W. Close, Antonietta M. Lillo, Eva Rose Murdock Balog, Csaba Kiss, Reginaldo C. Rocha, Andrew R.M. Bradbury, Koushik Ghosh, Prakash Sista, Hsing-Lin Wang, Charlie E. Strauss
  • Compositions and methods for selecting open reading frames
    Publication number: 20030235814
    Abstract: The current invention provides method and vectors for selecting open reading frames. Open reading frames present in a fragment of DNA cloned into the vectors of the invention result in creation of a fusion protein between the amino acid sequence encoded by the fusion protein and a reporter protein. The vector further comprises recombination sites so that once a recombinant that comprises an open reading frame is identified, either the reporter sequence or the open reading frame can be removed from the vector.
    Type: Application
    Filed: June 19, 2002
    Publication date: December 25, 2003
    Applicant: Los Alamos National Laboratory
    Inventors: Andrew R.M. Bradbury, Roberto Marzari