Abstract: An iron-air battery including an iron electrode in contact with an anode current collector, wherein the iron electrode includes a plurality of channels; an oxygen reduction reaction electrode having a first surface facing the plurality of channels and an opposing second surface in contact with air; an oxygen evolution reaction electrode interdigitated with the plurality of channels of the iron electrode, wherein at least a portion of the oxygen evolution reaction electrode is disposed within the plurality of channels in a direction perpendicular to a plane of the oxygen reduction reaction electrode; and an electrolyte in contact with the iron electrode, the first surface of the oxygen reduction reaction electrode, the plurality of channels, and the oxygen evolution reaction electrode.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A toy includes a magnetically responsive member, a fulcrum member, a printed circuit board (PCB), a lid covering the PCB, an activation switch, a touch sensor, a motion sensor, an audio transducer, a signal generator and a controller. The flexible PCB includes an electromagnetic coil, and a plurality of light emitting diodes (LEDs). Opening of the lid actuates the activation switch, and in response, the controller controls the signal generator to generate a coil control signal for the electromagnetic coil to produce a magnetic field that interacts with the magnetically responsive member, to induce oscillatory flapping of the PCB. In response to detecting a touch signal from the controller, or a motion signal from the motion sensor, the controller also generates a LED control signal to control illumination of the LEDs while the PCB is flapping, and an audio control signal to control the audio transducer to output sound.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: In an aspect, first interaction data characterizing a first interaction of a user with a mobile device configured to operate an application client can be received. A plurality of segments of users of the application client can be determined, and each of the plurality of segments can be associated with one or more settings that characterize an operating parameter of the application client. The user can be assigned to a first segment of the determined plurality of segments based on a correspondence between a characteristic of the user and a characteristic associated with the first segment. The application client can be modified based on the one or more settings associated with the first segment. The modified application client can be provided for interaction by the user via the mobile device. Related systems, apparatus, techniques, and articles are also described.

Abstract: A toy includes a magnetically responsive member, a fulcrum member, a printed circuit board (PCB), a lid covering the PCB, an activation switch, a touch sensor, a motion sensor, an audio transducer, a signal generator and a controller. The flexible PCB includes an electromagnetic coil, and a plurality of light emitting diodes (LEDs). Opening of the lid actuates the activation switch, and in response, the controller controls the signal generator to generate a coil control signal for the electromagnetic coil to produce a magnetic field that interacts with the magnetically responsive member, to induce oscillatory flapping of the PCB. In response to detecting a touch signal from the controller, or a motion signal from the motion sensor, the controller also generates a LED control signal to control illumination of the LEDs while the PCB is flapping, and an audio control signal to control the audio transducer to output sound.

Abstract: In an aspect, a request, from a first user of a plurality of users of an application client executing on respective mobile devices of the plurality of users, to interact with one or more other users of the plurality of users in the application client, based on a first plurality of interaction templates selected by the first user, can be received. A second user associated with a second interaction template can be determined from the plurality of users, and the determination can be based on an identification of a match between the second interaction template and a first interaction template from the first plurality of interaction templates. Interaction in the application client, between the first user and the second user, can be initiated in response to the determination of the second user. Related systems, apparatus, techniques, and articles are also described.

Abstract: In an aspect, first interaction data characterizing a first interaction of a user with a mobile device configured to operate an application client can be received. A plurality of segments of users of the application client can be determined, and each of the plurality of segments can be associated with one or more settings that characterize an operating parameter of the application client. The user can be assigned to a first segment of the determined plurality of segments based on a correspondence between a characteristic of the user and a characteristic associated with the first segment. The application client can be modified based on the one or more settings associated with the first segment. The modified application client can be provided for interaction by the user via the mobile device. Related systems, apparatus, techniques, and articles are also described.

Abstract: In an aspect, a request, from a first user of a plurality of users of an application client executing on respective mobile devices of the plurality of users, to interact with one or more other users of the plurality of users in the application client, based on a first plurality of interaction templates selected by the first user, can be received. A second user associated with a second interaction template can be determined from the plurality of users, and the determination can be based on an identification of a match between the second interaction template and a first interaction template from the first plurality of interaction templates. Interaction in the application client, between the first user and the second user, can be initiated in response to the determination of the second user. Related systems, apparatus, techniques, and articles are also described.

Abstract: A combined motor and gearbox assembly for an electric power steering system comprising an electric motor, a gearbox which includes a gearset that is connected on an input part to a rotor of the motor and in use is connected on an output part at least indirectly to a steering column shaft to transfer torque from the motor rotor to the steering column shaft, a motor drive circuit, a gearbox housing which in use accommodates the gearset of the gearbox, the electric motor including a motor housing, and a baseplate which connects an end face of the gearbox housing to an end face of the gearbox housing and which supports the drive circuit. At least one bolt having a stem passes through a central hole in a tubular rivet that secures the motor housing to the baseplate, the bolt securing the baseplate to the gearbox housing.

Abstract: In an aspect, first interaction data characterizing a first interaction of a user with a mobile device configured to operate an application client can be received. A plurality of segments of users of the application client can be determined, and each of the plurality of segments can be associated with one or more settings that characterize an operating parameter of the application client. The user can be assigned to a first segment of the determined plurality of segments based on a correspondence between a characteristic of the user and a characteristic associated with the first segment. The application client can be modified based on the one or more settings associated with the first segment. The modified application client can be provided for interaction by the user via the mobile device. Related systems, apparatus, techniques, and articles are also described.

Abstract: In an aspect, a request, from a first user of a plurality of users of an application client executing on respective mobile devices of the plurality of users, to interact with one or more other users of the plurality of users in the application client, based on a first plurality of interaction templates selected by the first user, can be received. A second user associated with a second interaction template can be determined from the plurality of users, and the determination can be based on an identification of a match between the second interaction template and a first interaction template from the first plurality of interaction templates. Interaction in the application client, between the first user and the second user, can be initiated in response to the determination of the second user. Related systems, apparatus, techniques, and articles are also described.

Abstract: A combined motor and gearbox assembly for an electric power steering system comprising an electric motor, a gearbox which includes a gearset that is connected on an input part to a rotor of the motor and in use is connected on an output part at least indirectly to a steering column shaft to transfer torque from the motor rotor to the steering column shaft, a motor drive circuit, a gearbox housing which in use accommodates the gearset of the gearbox, the electric motor including a motor housing, and a baseplate which connects an end face of the gearbox housing to an end face of the gearbox housing and which supports the drive circuit. At least one bolt having a stem passes through a central hole in a tubular rivet that secures the motor housing to the baseplate, the bolt securing the baseplate to the gearbox housing.

Abstract: An assembler for construction toy elements is provided. Each construction toy element has a plurality of arms extending from a body, wherein each arm includes a root end projecting from the body and a free end having a first connecting member thereon that is configured for connecting the construction toy element to another construction toy element. The assembler includes an alignment receptacle having a set of alignment structures defining positions along the alignment receptacle, each of the alignment structures receiving at least one of the construction toy elements and inhibiting movement thereof to other positions along the alignment receptacle. The assembler also includes a set of element conduits, each of the element conduits having a receiving opening securely receiving the at least one of the construction toy elements from a corresponding one of the positions along the alignment receptacle.