Patents by Inventor Andrew Richard Gorringe
Andrew Richard Gorringe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10967045Abstract: A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.Type: GrantFiled: April 12, 2010Date of Patent: April 6, 2021Assignee: Secretary of State for Health and Social CareInventors: Andrew Robinson, Margaret Robinson, Andrew Richard Gorringe, Michael John Hudson, Karen Margaret Reddin
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Publication number: 20110033491Abstract: A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.Type: ApplicationFiled: April 12, 2010Publication date: February 10, 2011Inventors: Andrew Robinson, Margaret Robinson, Andrew Richard Gorringe, Michael John Hudson, Karen Margaret Reddin
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Publication number: 20100092519Abstract: The present invention is in the field of combination therapies, including vaccine compositions, which comprise polysaccharide-protein conjugates and outer membrane vesicles (OMVs) from commensal bacteria, particularly commensal Neisseria.Type: ApplicationFiled: February 20, 2008Publication date: April 15, 2010Applicants: HEALTH PROTECTION AGENCY, SERUM INSTITUTE OF INDIA LIMITEDInventors: Andrew Richard Gorringe, Michelle Finney, Subhash V. Kapre, Akshay Goel
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Publication number: 20090148469Abstract: A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.Type: ApplicationFiled: October 20, 2008Publication date: June 11, 2009Inventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Karen Margaret Reddin
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Patent number: 7384645Abstract: A composition is prepared from a mixture of different vesicles, such as outer membrane vesicles (OMVs) and vaccines are based thereon. Another composition comprises in a single vesicle a combination of antigens and/or other vesicle components deriving from separate vesicles; again vaccines are prepared therefrom.Type: GrantFiled: December 17, 2002Date of Patent: June 10, 2008Assignee: Health Protection AgencyInventors: Keith Alan Foster, Andrew Richard Gorringe, Michael John Hudson, Karen Margaret Reddin, Andrew Robinson
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Patent number: 7157245Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.Type: GrantFiled: August 31, 2001Date of Patent: January 2, 2007Assignee: Health Protection AgencyInventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Philippa Bracegirdle, John Simon Kroll, Paul Richard Langford, Steven Anthony Rochford Webb, Keith Cartwright, Cliona Anne O'Dwyer, Karen Margaret Reddin
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Patent number: 7081244Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise conimensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-Neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.Type: GrantFiled: July 1, 2002Date of Patent: July 25, 2006Assignees: Health Protection Agency, Imperial College Innovations, Ltd.Inventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Philippa Bracegirdle, John Simon Kroll, Paul Richard Langford, Steven Anthony Rochford Webb, Keith Cartwright, Cliona Anne O'Dwyer
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Publication number: 20040265328Abstract: The invention provides methods of screening commensal and pathogenic bacteria for previously unidentified vaccine antigens, based upon identifying polypeptide antigens that bind to sera raised against commensal bacterial proteins. Also provided are vaccine compositions and methods of preparing vaccine compositions comprising the antigens identified by the screening methods. Antigens and uses thereof are also described.Type: ApplicationFiled: July 26, 2004Publication date: December 30, 2004Inventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Philippa Bracegirdle, David McKay West, Kerry Jane Oliver, John Simon Kroll, Paul Richard Langford
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Patent number: 6821521Abstract: A composition comprising Transferrin binding proteins A and B is described (TbpA and TbpB). The composition is suitable for use in vaccines and for treatment of Gram negative bacterial infection, particularly meningococcal infection, demonstrating a broad spectrum of protection to a number of different bacterial pathogens. Also described are compositions comprising Tbps and other components, such as neisserial outer membrane vesicles and Cu,Zn-Superoxide dismutase. Methods for preparation of these compositions and their uses in vaccination against disease are further provided.Type: GrantFiled: August 29, 2001Date of Patent: November 23, 2004Assignee: Health Protection AgencyInventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Karen Margaret Reddin
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Publication number: 20030215469Abstract: A composition is provided comprising N. meningitidis outer membrane vesicles, wherein said outer membrane vesicles are enriched with at least one antigenic component. The composition is suitable for use in vaccines and for treatment of infection, particularly meningococcal infection, demonstrating a broad spectrum of protection. A number of preferred antigenic components are described and include antigenic proteins and proteoglycans derived from N. meningitidis.Type: ApplicationFiled: December 17, 2002Publication date: November 20, 2003Applicant: Microbiological Research AuthorityInventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Karen Margaret Reddin
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Publication number: 20030186848Abstract: Neisserial iron uptake proteins including transferrin binding protein A (TbpA) and B (TbpB) in both full length form and as immunogenic fragments are made recombinantly. A non-neisserial cell expresses a TbpA which is extracted from the cell under mild conditions and retains substantially the antigenicity of native TbpA on its surface. TbpB is also made recombinantly and both TbpA and TbpB are included in vaccine compositions.Type: ApplicationFiled: April 24, 2003Publication date: October 2, 2003Inventors: Andrew Richard Gorringe, Michael John Hudson, Mary Anne Matheson, Andrew Robinson, David McKay West
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Publication number: 20030082211Abstract: Vaccine conjugates are described comprising a capsular polysaccharide antigen conjugated to a carrier molecule, which carrier molecule is a protein associated with iron uptake by pathogenic microorganisms. The vaccine conjugate may comprise second or additional antigens also conjugated to the carrier. In a preferred embodiment, the carrier is a transferrin binding protein, in particular TbpA or TbpB. Also described are methods for conjugating the antigen/s to the carrier molecule, and to the use of transferrin binding protein in the manufacture of a carrier-antigen conjugate for vaccination. Affinity matrices comprising immobilised ligand for an iron uptake protein, and the use thereof for purifying a vaccine conjugate according to the present invention are also described.Type: ApplicationFiled: September 12, 2002Publication date: May 1, 2003Inventors: Andrew Richard Gorringe, Andrew Robinson
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Publication number: 20030026809Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.Type: ApplicationFiled: August 31, 2001Publication date: February 6, 2003Inventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Philippa Bracegirdle, John Simon Kroll, Paul Richard Langford, Steven Anthony Rochford Webb, Keith Cartwright, Cliona Anne O'Dwyer, Karen Margaret Reddin
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Publication number: 20030021812Abstract: Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria. Further methods and compositions comprise commensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-Neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.Type: ApplicationFiled: July 1, 2002Publication date: January 30, 2003Applicant: Microbiological Research AuthorityInventors: Andrew Robinson, Andrew Richard Gorringe, Michael John Hudson, Philippa Bracegirdle, John Simon Kroll, Paul Richard Langford, Steven Anthony Rochford Webb, Keith Cartwright, Cliona Anne O'Dwyer