Abstract: The present invention provides mammalian GPR39 gene, its coded products, and the uses in regulating appetite and pain sensitivity. A pharmaceutical composition and a health product comprising GPR39 protein are also provided. The health product and the pharmaceutical composition for suppressing appetite or decreasing pain sensitivity comprise a safe and efficient amount of antagonists of mammalian GPR39 protein (for example, 0.01-99%) and a bromatologically or pharmaceutically acceptable carrier in a suitable amount (for example 1-99.99 wt %).

Abstract: Association of Type 2 diabetes with single nucleotide polymorphisms and haplotypes are disclosed. Also disclosed are diagnostic applications in identifying those who have Type 2 diabetes or are at risk of developing Type 2 diabetes, and discovery of therapeutic agents and methods of treatment.

Abstract: The present invention generally relates to large capacity (e.g., greater than 350 tons/day O2) vacuum pressure adsorption (VPSA) systems and processes that employ a single train including four beds, at least one feed compressor feeding two beds simultaneously at any given instant in time, and a single vacuum pump. The compressor(s) and the vacuum pump can be utilized 100% of the time. Use of product quality gas for purging is avoided, with about 10-20% improvement in O2 productivity and 5-10% reduction in capital cost expected.

Abstract: The present invention generally relates to large capacity (e.g., greater than 350 tons/day O2) vacuum pressure adsorption (VPSA) systems and processes that employ a single train including four beds, at least one feed compressor feeding two beds simultaneously at any given instant in time, and a single vacuum pump. The compressor(s) and the vacuum pump can be utilized 100% of the time. Use of product quality gas for purging is avoided, with about 10-20% improvement in O2 productivity and 5-10% reduction in capital cost expected.

Abstract: The present invention generally relates to large capacity (e.g., greater than 350 tons/day O2) vacuum pressure adsorption (VPSA) systems and processes that employ a single train including four beds, at least one feed compressor feeding two beds simultaneously at any given instant in time, and a single vacuum pump. The compressor(s) and the vacuum pump can be utilized 100% of the time. Use of product quality gas for purging is avoided, with about 10-20% improvement in O2 productivity and 5-10% reduction in capital cost expected.

Abstract: A three-bed pressure swing adsorption system providing a constant continuous supply gas, preferably containing a hydrogen component, in a multi-step and preferably in a twelve-step, process cycle that can produce a purified gas product, preferably hydrogen, on a constant flow.

Abstract: The present invention relates to a PSA system using an indexing rotary dual valve regulating a stepping mode of operation that controls a variable bed inlet feed flow rate, controllable pressure between feed lines in different beds of the PSA system and varied output flow rate of product gas such as high purity hydrogen gas.

Abstract: Sequence #115, a G protein-coupled receptor, has been identified as a target for identifying weight modulating compounds. Compounds that modulate sequence #115 are useful for the treatment of obesity and cachexia. Cell-based and cell-free assays are described to identify compounds which bind to and/or activate or inhibit the activity of sequence #115.