Abstract: Embodiments of a temperature control case and related methods and systems are disclosed. Some embodiments may be particularly useful for portable storage of temperature-sensitive pharmaceutical substances and the like. Embodiments are also disclosed which are configured specifically for cooling intravenous fluids to be used for therapeutic hypothermia. Some embodiments may include multiple storage compartments each being configured to store substances at a different temperature so that intravenous fluids can be stored in one compartment and other substances in another compartment. Some embodiments include both internal and external temperature sensors to allow the device to predict internal temperature changes and adjust heating/cooling elements accordingly before the internal temperature is unduly impacted by the ambient temperature, thereby increasing the efficiency and efficacy of the temperature control system.