Abstract: Methods and apparatuses for highly sensitive detection of analytes using redox reactions. A library of heat reactions of analytes of interest with a variety of catalysts at a variety of temperatures is prepared. An array of sensors with low thermal mass heating elements is prepared, depositing the same or different catalysts, such as metal oxide catalysts that have multiple oxidation states, on each heating element. The low thermal mass heating elements are preferably not in thermal contact with a substrate, or a low mass substrate is used. The array is exposed to a sample at various temperatures. The sign and magnitude of the heat effect of the redox reaction of compounds in the sample or their decomposition products with each catalyst is measured and compared with the library. The catalysts and temperatures are chosen so that the desired analytes have a unique pattern of heat effect signs and magnitudes when reacted with those catalysts at those temperatures.

Abstract: A method for imaging retinal structures involves offsetting an imaging aperture from the center of the reflected/scattered light distribution. Images are obtained with the imaging aperture at multiple offsets with respect to the center. The various obtained images are co-registered to a reference confocal image in a reference wavelength and averaged to generate high signal to noise ratio images. The images may be combined in various ways to enhance the contrast of retinal structures that would not be visible in confocal images.

Abstract: Methods and apparatus for imaging multiple retinal structures and montaging of multiple retinal images are provided. The method involves cross-correlating images from different imaging channels to compensate for intra-frame distortion due to retinal movement during image acquisition, and conducting a second cross-correlation to filter out any motion artifacts in the images. The resultant images are combined to generate a composite image. The method also involves controlling light directed on the retina spatially and temporally.

Abstract: A method for imaging retinal structures involves offsetting an imaging aperture from the center of the reflected/scattered light distribution. Images are obtained with the imaging aperture at multiple offsets with respect to the center. The various obtained images are co-registered to a reference confocal image in a reference wavelength and averaged to generate high signal to noise ratio images. The images may be combined in various ways to enhance the contrast of retinal structures that would not be visible in confocal images.

Abstract: Methods and apparatus for imaging multiple retinal structures and montaging of multiple retinal images are provided. The method involves cross-correlating images from different imaging channels to compensate for intra-frame distortion due to retinal movement during image acquisition, and conducting a second cross-correlation to filter out any motion artifacts in the images. The resultant images are combined to generate a composite image. The method also involves controlling light directed on the retina spatially and temporally.