Patents by Inventor Andrew Roughton

Andrew Roughton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20230406884
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Application
    Filed: June 8, 2023
    Publication date: December 21, 2023
    Inventors: Mohammed Monzur MORSHED, Sai Kumar CHAKKA, Jennifer L. HICKEY, Manuel Perez VAZQUEZ, Andrew ROUGHTON, Adam Paul KAFAL, Narendrakumar B. PATEL
  • COMPOUNDS TARGETING ALPHA4-BETA7 INTEGRIN
    Publication number: 20230295235
    Abstract: Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, are described. The compounds are ?4?7 antagonists and are useful in the prevention or treatment of inflammatory conditions and/or autoimmune diseases, especially inflammatory bowel disease.
    Type: Application
    Filed: June 25, 2021
    Publication date: September 21, 2023
    Inventors: Andrew Roughton, Narendrakumar Patel, Adam Paul Kafal, Manuel Perez Vazquez, Jennifer Hickey, Sai Kumar Chakka, Monzur Morshed
  • Cyclic peptides multimers targeting ?-4-?-7 integrin
    Patent number: 11713338
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: August 1, 2023
    Assignee: Zealand Pharma A/S
    Inventors: Mohammed Monzur Morshed, Sai Kumar Chakka, Jennifer L. Hickey, Manuel Perez Vazquez, Andrew Roughton, Adam Paul Kafal, Narendrakumar B. Patel
  • Homodetic cyclic peptides targeting alpha-4-beta-7 integrin
    Patent number: 11286281
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly cyclic peptide antagonists, such as compounds of formula (I).
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 29, 2022
    Assignee: Zealand Pharma A/S
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Adam Paul Kafal, Jennifer L. Hickey, Andrew Roughton
  • CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20210324007
    Abstract: There is described herein, multimers comprising plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Application
    Filed: April 19, 2021
    Publication date: October 21, 2021
    Inventors: Mohammed Monzur MORSHED, Sai Kumar CHAKKA, Jennifer L. HICKEY, Manuel Perez VAZQUEZ, Andrew ROUGHTON, Adam Paul KAFAL, Narendrakumar B. PATEL
  • Cyclic peptides multimers targeting alpha-4-beta-7 integrin
    Patent number: 11111273
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: September 7, 2021
    Assignee: Zealand Pharma A/S
    Inventors: Mohammed Monzur Morshed, Sai Kumar Chakka, Jennifer L. Hickey, Manuel Perez Vazquez, Andrew Roughton, Adam Paul Kafal, Narendrakumar B. Patel
  • CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20200216501
    Abstract: There is described herein, multimers comprising a plurality of compounds covalently linked together, the compounds independently being of formula (I).
    Type: Application
    Filed: November 10, 2017
    Publication date: July 9, 2020
    Inventors: Mohammed Monzur MORSHED, Sai Kumar CHAKKA, Jennifer L. HICKEY, Manuel Perez VAZQUEZ, Andrew ROUGHTON, Adam Paul KAFAL, Narendrakumar B. PATEL
  • HOMODETIC CYCLIC PEPTIDES TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20200095285
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly cyclic peptide antagonists, such as compounds of formula (I).
    Type: Application
    Filed: May 10, 2018
    Publication date: March 26, 2020
    Inventors: Manuel Perez VAZQUEZ, M. Monzur MORSHED, Adam Paul KAFAL, Jennifer L. HICKEY, Andrew ROUGHTON
  • FLAVIN DERIVATIVES
    Publication number: 20130029980
    Abstract: The present invention relates novel flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives.
    Type: Application
    Filed: April 6, 2011
    Publication date: January 31, 2013
    Inventors: Philip D. G. Coish, Brian R. Dixon, David Osterman, Paul Adrian Aristoff, Manuel Navia, Frank Sciavolino, Stephanie Avola, Nick Baboulas, Thomas R. Belliotti, Angelica Bello, Judd Berman, Robert A. Chrusciel, Bruce R. Evans, Harpreet Kaur, David Moon, Vinh Pham, Andrew Roughton, Phil Wickens, Jeffrey Wilson, Heinrich J. Schostarez
  • FLAVIN DERIVATIVES
    Publication number: 20120295903
    Abstract: The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.
    Type: Application
    Filed: June 30, 2010
    Publication date: November 22, 2012
    Inventors: Kenneth F. Blount, Philip D.G. Coish, Brian R. Dixon, Jayhyuk Myung, David Osterman, Phil Wickens, Stephanie Avola, Nick Baboulas, Angelica Bello, Judd Berman, Harpreet Kaur, David Moon, Vinh Pham, Andrew Roughton, Jeffrey Wilson, Jeffrey A. Leiby, Dennis Underwood, Paul Adrian Aristoff, Heinrich J. Schostarez, Robert A. Chrusciel, Thomas R. Belliotti, Bruce R. Evans, Frank C. Sciavolino, Manuel A. Navia
  • Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
    Patent number: 7989459
    Abstract: A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC?. inhibitors, and their methods of use are disclosed. The genus is represented by the formula I: wherein R1 is chosen from nitrogen-attached heterocyclyl, nitrogen-attached substituted heterocyclyl wherein the point of attachment is a nitrogen heteroatom, and R2 is chosen from aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, hetroarylalkyl, and substituted heteroarylalkyl.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: August 2, 2011
    Assignee: Pharmacopeia, LLC
    Inventors: Andrew Roughton, Yajing Rong, Koc Kan Ho, Michael Ohlmeyer, David Diller
  • Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
    Publication number: 20080085909
    Abstract: A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC? inhibitors, and their methods of use are disclosed.
    Type: Application
    Filed: February 2, 2007
    Publication date: April 10, 2008
    Applicant: Pharmacopeia Drug Discovery, Inc.
    Inventors: Andrew Roughton, Yajing Rong, Koc Kan Ho, Michael Ohlmeyer, David Diller