Abstract: An optical system (31) for analysing biological processes comprising: a biological process vessel (33) comprising a chamber and an optical interface element (34) for optically coupling the chamber to an optical emitter, a wavelength discrimination component, and an optical detector when a biological process fluid in the chamber is being analysed, the optical interface element being configured to couple light in the mid-infrared range; an optical emitter (351) configured to emit light in the mid-infrared range; an optical detector (353) configured to detect light in the mid-infrared range; a wavelength discrimination component (352); an alignment component (42) for aligning the optical emitter, optical detector, and wavelength discrimination component with the optical interface element; and a processor (354) configured to: receive outputs from the optical detector; and process the received outputs from the optical detector to provide an indication of the constituents of a biological process fluid in the chambe

Abstract: The present application relates to the treatment of plant nematode infections. For example, the application relates to the use of one or more compounds of Formula (I) as defined herein, or compositions comprising these compounds, for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection in a plant in need thereof. Also included are novel compounds within the scope of Formula I and compositions and uses of these compounds for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection in a plant in need thereof.

Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.

Abstract: A context-information-dependent instruction causes a context-information-dependent operation to be performed based on specified context information indicative of a specified execution context. A context information translation cache 10 stores context information translation entries each specifying untranslated context information and translated context information. Lookup circuitry 14 performs a lookup of the context information translation cache based on the specified context information, to identify whether the context information translation cache includes a matching context information translation entry which is valid and which specifies untranslated context information corresponding to the specified context information. When the matching context information translation entry is identified, the context-information-dependent operation is performed based on the translated context information specified by the matching context information translation entry.

Abstract: This specification generally relates to an improved method for the manufacture of 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine (I), or pharmaceutically acceptable salts thereof, polymorphic forms thereof, and intermediates useful in the manufacture of such compounds and salts thereof.

Abstract: A water management system including a first end point device in communication with a first fixture, the first end point including a first end point electronic processor configured to receive data associated with the first fixture and a first fixture identifier. The water management system also includes a non-transitory computer-readable medium storing instructions executable by at least one electronic processor to perform a set of functions, such as receiving the data associated with the first fixture and the first fixture identifier, associating the first fixture identifier with a first location classification and a first type classification, processing the data associated with the first fixture to organize the data based at least in part on the first location classification associated with the first fixture identifier or the first type classification associated with the first fixture identifier, and transmitting the organized data of the first fixture to a user device for display.

Abstract: A method and apparatus is presented. A portion is cut from a thermoplastic sheet of a first thermoplastic material based on a three dimensional model. The portion is secured to a mold. The portion and the mold are heated under vacuum to form a structure. The structure may take the form of a protective covering. In some illustrative examples, the mold may be formed of a second thermoplastic material based on the three dimensional model using additive manufacturing.

Abstract: A closed system suitable for the aseptic culturing of therapeutic cells. The present system facilitates the aseptic manufacturing of cells for use in therapy, without the need for a clean-room environment because no open processing steps are required.

Abstract: A method and apparatus is presented. A portion is cut from a thermoplastic sheet of a first thermoplastic material based on a three dimensional model. The portion is secured to a mold. The portion and the mold are heated under vacuum to form a structure. The structure may take the form of a protective covering. In some illustrative examples, the mold may be formed of a second thermoplastic material based on the three dimensional model using additive manufacturing.

Abstract: A method and apparatus is presented. A portion is cut from a thermoplastic sheet of a first thermoplastic material based on a three dimensional model. The portion is secured to a mold. The portion and the mold are heated under vacuum to form a structure. The structure may take the form of a protective covering. In some illustrative examples, the mold may be formed of a second thermoplastic material based on the three dimensional model using additive manufacturing.

Abstract: A closed system suitable for the aseptic culturing of therapeutic cells. The present system facilitates the aseptic manufacturing of cells for use in therapy, without the need for a clean-room environment because no open processing steps are required.

Abstract: A closed system suitable for the aseptic culturing therapeutic cells comprises a vessel comprising: a gas permeable portion suitable for supporting cell growth and allowing delivery of gases to the cells during culturing, a vent comprising a conduit having an exterior orifice and an interior orifice spaced apart therefrom, the vent extending from the exterior of the system into the internal volume of the vessel and terminating therein with the interior orifice, wherein the interior orifice is arranged such that during filling and emptying of liquid medium it is not susceptible to blockage by liquid, the exterior orifice is adapted to connect to an aseptic filter thereby allowing passage of gases through the filter into the vessel or out of the vessel, as required to achieve the entry and exit of fluids and cells into the vessel, a port or ports adapted to allow introduction of fluids and cells aseptically into the vessel, and a port or ports adapted to allow fluids to exit the system without exposing the syst

Abstract: A method and apparatus is presented. A portion is cut from a thermoplastic sheet of a first thermoplastic material based on a three dimensional model. The portion is secured to a mold. The portion and the mold are heated under vacuum to form a structure. The structure may take the form of a protective covering. In some illustrative examples, the mold may be formed of a second thermoplastic material based on the three dimensional model using additive manufacturing.

Abstract: Tools and methods in which user interaction via a common user interface enables the assessing of network security prior to implementation of the network, as well as assessing the security of existing networks, portions of existing networks, or modifications to existing networks. A network security model useful in realizing the tools and methods is also disclosed.

Abstract: A document scanner comprises a first image sensor unit (32) and a second image sensor unit (30) and a scanning mechanism (70, 72, 76, 80) for causing relative movement between a document and the units so that the units scan the document in a scanning direction. The first unit (32) is situated ahead of the second unit (30) in the scanning direction and partially overlaps the second unit.

Abstract: A closed system suitable for the aseptic culturing therapeutic cells comprises a vessel comprising: a gas permeable portion suitable for supporting cell growth and allowing delivery of gases to the cells during culturing, a vent comprising a conduit having an exterior orifice and an interior orifice spaced apart therefrom, the vent extending from the exterior of the system into the internal volume of the vessel and terminating therein with the interior orifice, wherein the interior orifice is arranged such that during filling and emptying of liquid medium it is not susceptible to blockage by liquid, the exterior orifice is adapted to connect to an aseptic filter thereby allowing passage of gases through the filter into the vessel or out of the vessel, as required to achieve the entry and exit of fluids and cells into the vessel, a port or ports adapted to allow introduction of fluids and cells aseptically into the vessel, and a port or ports adapted to allow fluids to exit the system without exposing the syst

Abstract: A document scanner comprises first and second image sensor units (30,32), each having an array of electromagnetic radiation detectors (44) situated adjacent circuitry (42) for operating the detectors. A scanning mechanism (70,72,76,78,80) causes relative movement between the detectors and a document to cause the detectors to scan the document along a scanning direction. The array of detectors of the first unit (30) is situated ahead of the array of detectors of the second unit (32) in said scanning direction, the orientation of the detectors of the first unit with respect to their circuitry thus being the reverse of that of the detectors of the second unit, thereby to reduce the distance, in the scanning direction, between the two arrays.