Patents by Inventor Andrew S. Chi

Andrew S. Chi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused Bicyclic Heterocycles as Therapeutic Agents
    Publication number: 20210395222
    Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to nicotinamide phosphoribosyltransferase (NAM FT) expression. More particularly, this disclosure relates to fused bicyclic heterocyclic compounds and pharmaceutical compositions thereof, methods of inhibiting NAM FT with these compounds, and methods of treating diseases related to NAMPT expression.
    Type: Application
    Filed: October 5, 2019
    Publication date: December 23, 2021
    Inventors: John K. DICKSON, Andrew S. CHI, Xinyan HUANG, Nadim SHOHDY
  • Methods for the treatment of vascularizing cancers
    Patent number: 10100115
    Abstract: The invention concerns therapeutic compositions for the treatment of vascularizing cancers, especially, glioblastoma. In particular, the invention is directed to compositions that comprise a molecule having a binding ability that is specific for B7-H3 and a molecule having a binding ability that is specific for a cell-surface factor (or its receptor) that is involved in promoting tumor angiogenesis (especially VEGF or its receptor, VEGFR). The invention is additionally directed to the use of such compositions in the treatment of such cancers, and in particular, in the treatment of glioblastoma.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: October 16, 2018
    Assignee: MacroGenics, Inc.
    Inventor: Andrew S. Chi
  • Improved Methods for the Treatment of Vascularizing Cancers
    Publication number: 20170008961
    Abstract: The invention concerns therapeutic compositions for the treatment of vascularizing cancers, especially, glioblastoma. In particular, the invention is directed to compositions that comprise a molecule having a binding ability that is specific for B7-H3 and a molecule having a binding ability that is specific for a cell-surface factor (or its receptor) that is involved in promoting tumor angiogenesis (especially VEGF or its receptor, VEGFR). The invention is additionally directed to the use of such compositions in the treatment of such cancers, and in particular, in the treatment of glioblastoma.
    Type: Application
    Filed: February 11, 2015
    Publication date: January 12, 2017
    Inventor: Andrew S. Chi