Patents by Inventor Andrew S. Little

Andrew S. Little has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
    Patent number: 7011976
    Abstract: Replication competent adenoviral vectors specific for cells expressing alfa-fetoprotein (AFP) are provided. These replication-competetent adenoviral vectors comprise adenovirus genes essential for replication under the transcriptional control of an AFP-transcriptional regulatory element.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: March 14, 2006
    Assignee: Calydon, Inc.
    Inventors: Andrew S. Little, Henry G. Lamparski, Daniel R. Henderson, Eric R. Schuur
  • Compositions comprising tissue specific adenoviral vectors
    Patent number: 7001764
    Abstract: Compositions comprising host cell specific adenovirus vehicles are provided for transfecting target host cells. The compositions comprise replication competent adenovirus having an adenovirus gene essential for replication under transcriptional control of a cell type specific transcriptional response element (TRE) and polyethylene glycol (PEG) as a masking agent.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: February 21, 2006
    Assignee: Cell Genesys, Inc.
    Inventors: Andrew S. Little, Henry G. Lamparski, Daniel R. Henderson, Eric R. Schuur
  • Cell-specific adenovirus vectors comprising an internal ribosome entry site
    Publication number: 20040146489
    Abstract: Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional regulatory element (TRE), wherein the second gene is under translational control of an internal ribosome entry site. Methods for the preparation and use of such vectors are also provided. The vectors provide target cell-specific virus replication in applications such as cancer therapy and gene therapy.
    Type: Application
    Filed: October 21, 2003
    Publication date: July 29, 2004
    Inventors: De-Chao Yu, Yuanhao Li, Andrew S. Little, Daniel R. Henderson
  • Cell-specific adenovirus vectors comprising an internal ribosome entry site
    Patent number: 6692736
    Abstract: Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional regulatory element (TRE), wherein the second gene is under translational control of an internal ribosome entry site. Methods for the preparation and use of such vectors are also provided. The vectors provide target cell-specific virus replication in applications such as cancer therapy and gene therapy.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: February 17, 2004
    Assignee: Cell Genesys, Inc.
    Inventors: De-Chao Yu, Yuanhao Li, Andrew S. Little, Daniel R. Henderson
  • Compositions comprising tissue specific adenoviral vectors
    Publication number: 20030152553
    Abstract: Compositions comprising host cell specific adenovirus vehicles are provided for transfecting target host cells. The compositions comprise replication competent adenovirus having an adenovirus gene essential for replication under transcriptional control of a cell type specific transcriptional response element (TRE) and polyethylene glycol (PEG) as a masking agent.
    Type: Application
    Filed: May 2, 2002
    Publication date: August 14, 2003
    Inventors: Andrew S. Little, Henry G. Lamparski, Daniel R. Henderson, Eric R. Schuur
  • Cell-specific adenovirus vectors comprising an internal ribosome entry site
    Publication number: 20030148520
    Abstract: Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional regulatory element (TRE), wherein the second gene is under translational control of an internal ribosome entry site. Methods for the preparation and use of such vectors are also provided. The vectors provide target cell-specific virus replication in applications such as cancer therapy and gene therapy.
    Type: Application
    Filed: March 21, 2001
    Publication date: August 7, 2003
    Inventors: De-Chao Yu, Yuanhao Li, Andrew S. Little, Daniel R. Henderson
  • Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
    Patent number: 6585968
    Abstract: Adenovirus vectors replication specific for cells expressing &agr;-fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: July 1, 2003
    Assignee: Cell Genesys, Inc.
    Inventors: Andrew S. Little, Daniel R. Henderson, Eric R. Schuur, Henry Lamparski
  • Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
    Publication number: 20020164799
    Abstract: Adenovirus vectors replication specific for cells expressing &agr;-fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP.
    Type: Application
    Filed: July 2, 2001
    Publication date: November 7, 2002
    Inventors: Andrew S. Little, Daniel R. Henderson, Eric R. Schuur, Henry Lamparski
  • Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
    Patent number: 6254862
    Abstract: Adenovirus vectors replication specific for cells expressing &agr;-fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: July 3, 2001
    Assignee: Calydon, Inc.
    Inventors: Andrew S. Little, Daniel R. Henderson, Eric R. Schuur, Henry Lamparski