Patents by Inventor Andrew S. THOMSON

Andrew S. THOMSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PURIFYING ANTIBODIES
    Publication number: 20230046182
    Abstract: The present invention relates to a method of purifying a recombinant polypeptide from Host Cell Proteins (HCP), the method comprising: (a) applying a solution comprising the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer comprising caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support.
    Type: Application
    Filed: November 1, 2022
    Publication date: February 16, 2023
    Inventors: Andre C. DUMETZ, Kent E. GOKLEN, Nicholas E. LEVY, Jessica Rachel, Andrew S. THOMSON, Kenneth G. YANCEY
  • Methods for purifying antibodies
    Patent number: 11530238
    Abstract: The present invention relates to a method of purifying a recombinant polypeptide from Host Cell Proteins (HCP), the method comprising: (a) applying a solution comprising the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer comprising caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: December 20, 2022
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Andre C. Dumetz, Kent E. Goklen, Nicholas E. Levy, Jessica Rachel Molek, Andrew S. Thomson, Kenneth G. Yancey
  • Antibodies with reduced binding to process impurities
    Patent number: 11254753
    Abstract: The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: February 22, 2022
    Inventors: Hella Bosteels, Shugui Chen, Kayeleigh Farrow, Richard Kucia-Tran, William John Kenneth Lewis, Andrew S. Thomson, Mark Uden
  • METHODS FOR PURIFYING ANTIBODIES
    Publication number: 20210284686
    Abstract: The present invention relates to a method of purifying a recombinant polypeptide from Host Cell Proteins (HCP), the method comprising: (a) applying a solution comprising the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer comprising caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support.
    Type: Application
    Filed: September 6, 2017
    Publication date: September 16, 2021
    Inventors: Andre C. DUMETZ, Kent E GOKLEN, Nicolas E LEVY, Jessica Rachel MOLEK, Andrew S. THOMSON, Kenneth G. YANCY
  • METHODS FOR PURIFYING ANTIBODIES
    Publication number: 20210054023
    Abstract: A method of purifying a recombinant polypeptide from Host Cell Proteins (HCP) is provided. The method includes: (a) applying a solution containing the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer containing caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support, wherein the recombinant polypeptide is an anti-ICOS antibody or antigen binding fragment thereof.
    Type: Application
    Filed: March 6, 2019
    Publication date: February 25, 2021
    Inventors: Andre C. DUMETZ, Ken E. GOKLEN, Nicholas E. LEVY, Jessica R. MOLEK, Andrew S. THOMSON, Kenneth G. YANCEY
  • METHODS FOR PURIFYING RECOMBINANT POLYPEPTIDES
    Publication number: 20210054051
    Abstract: A method of purifying a recombinant polypeptide from a Host Cell Protein (HCP), wherein the amino acid sequence of the recombinant polypeptide comprises a cathepsin L cleavage site is provided. The method includes: (a) applying a solution containing the recombinant polypeptide and HCP to a superantigen chromatography solid support, (b) washing the superantigen chromatography solid support with a wash buffer containing caprylate and arginine; and (c) eluting the recombinant polypeptide from the superantigen chromatography solid support. A method of purifying an anti-OX40 antigen binding polypeptide from a Host Cell Protein (HCP) is also provided.
    Type: Application
    Filed: March 6, 2019
    Publication date: February 25, 2021
    Inventors: Andre DUMETZ, Kent E. GOKLEN, Nicholas E. LEVY, Jessica Rachel MOLEK, Andrew S. THOMSON, Kenneth G. YANCEY
  • ANTIBODIES WITH REDUCED BINDING TO PROCESS IMPURITIES
    Publication number: 20190225708
    Abstract: The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.
    Type: Application
    Filed: October 3, 2017
    Publication date: July 25, 2019
    Inventors: Hella BOSTEELS, Shugui CHEN, Kayeleigh FARROW, Richard KUCIA-TRAN, William John Kenneth LEWIS, Andrew S. THOMSON, Mark UDEN