Publication number: 20230100616
Abstract: Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk in a patient with a respiratory illness, the method comprising: a. obtaining a sample obtained from the patient; b. quantitatively measuring in the sample a polypeptide level of one or more biomarkers selected from: IL-6, CXCL8, IL-10, IL-IRA, IL-2, IL-4, IL-7, IL-9, IL-13, IL-17, IFN-g, IP-10, MCP-1, G-CSF, GM-CSF, FGF-basic, SCGF-?, GRO-?, MIP1-?, MIP1-?, CK-18, PDGF-bb, caspase 3, HMGB-1, TNF ?, VEGF, sTNFR1 and sTREM1; and c. i) comparing the level of the one or more biomarkers in the sample with a control or cut-off level, wherein the differential level is indicative of patient outcome risk; or ii) using the polypeptide level of several of the biomarkers in combination, as inputs for an algebraic calculation or machine learning model of patient outcome risk.
Type:
Application
Filed:
March 15, 2021
Publication date:
March 30, 2023
Inventors:
Andrew Sage, Jerome Valero, Lorenzo Del Sorbo, Marcelo Cypel, Bo Wang, Shafique Keshavjee