Abstract: Described herein are compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof. Also disclosed are compositions containing the compounds, methods of inhibiting activity of DYRK1A in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: A smart city management system may enable creating a digital twin of the smart city based on mapping lidar data for the smart city and radio frequency data for the smart city; determining placement of a set of network devices in the smart city based on the created digital twin; and providing a visualization of the determined placement of the set of network devices.

Abstract: In an embodiment, a system for synchronizing the rotation of multiple mainframes of an airship includes multiple belt drive systems configured to mechanically rotate the mainframes, a central control system for sending a timing instruction to cause the mainframes to rotate synchronously about their respective rotational axis, wherein the mainframes are axis-aligned about their respective rotational axes and the timing instruction specifies a desired angular displacement of the mainframes, and multiple control units for controlling the belt drive systems to rotate the mainframes, respectively, wherein, for each mainframe, the associated control unit is configured to: receive the timing instruction from the central control system; determine, according to the timing instruction, a rotation instruction based on a size of the mainframe and the desired angular displacement; and instruct the belt drive system controlled by the control unit to rotate the mainframe based on the rotation instruction.

Abstract: In an embodiment, a system for synchronizing the rotation of multiple mainframes of an airship includes multiple belt drive systems configured to mechanically rotate the mainframes, a central control system for sending a timing instruction to cause the mainframes to rotate synchronously about their respective rotational axis, wherein the mainframes are axis-aligned about their respective rotational axes and the timing instruction specifies a desired angular displacement of the mainframes, and multiple control units for controlling the belt drive systems to rotate the mainframes, respectively, wherein, for each mainframe, the associated control unit is configured to: receive the timing instruction from the central control system; determine, according to the timing instruction, a rotation instruction based on a size of the mainframe and the desired angular displacement; and instruct the belt drive system controlled by the control unit to rotate the mainframe based on the rotation instruction.

Abstract: A protective cover is configured to protect a grip end of a bat. For example, a baseball bat, a softball bat, a cricket bat or other bat. The protective cover has a substantially cylindrical body and an open end for receiving the grip end of the bat. In some embodiments, the grip end of the bat is inserted into the open top end of the body and the body is slid onto and over the grip end to couple the protective cover with the bat. Alternatively, the body may be placed on the grip end of the bat and zipped and/or otherwise closed to couple with and protect the grip end of the bat. The protective cover protects the grip end of the bat from damage as well as provides cushion to prevent damage to external objects and injury to other individuals when the bat is not being used.

Abstract: A protective cover is configured to protect a grip end of a bat. For example, a baseball bat, a softball bat, a cricket bat or other bat. The protective cover has a substantially cylindrical body and an open end for receiving the grip end of the bat. In some embodiments, the grip end of the bat is inserted into the open top end of the body and the body is slid onto and over the grip end to couple the protective cover with the bat. Alternatively, the body may be placed on the grip end of the bat and zipped and/or otherwise closed to couple with and protect the grip end of the bat. The protective cover protects the grip end of the bat from damage as well as provides cushion to prevent damage to external objects and injury to other individuals when the bat is not being used.

Abstract: A notification framework and method that quickly sends invitations one device to another device to join devices to collaboration session. Devices may be provided with an application that enables a user to register with a registry service. The registry service is provided as a mechanism to enable delivery of a collaboration invitation and joining of participants in the collaborative session. Notification invitations containing a collaboration URL may then be forwarded via a push service to the invited registrants. Each invited registrant is then provided an option to accept invitation and automatically join the session with the user. In another example, the host user may “pass” or “share” a session to an invited registrant rather than having an invited registrant join a session.

Abstract: A system and method for datacenter power management is disclosed. In particular embodiments, the method includes receiving, with a processor, a request for execution of an application. The method also includes for each of a plurality of datacenters, determining an amount of electricity required to execute the application at the respective datacenter. The method also includes, for each of the plurality of datacenters, determining a cost associated with executing the application at the respective datacenter based, at least in part, on the amount of electricity required to execute the application at the respective datacenter. The method further includes selecting one of the plurality of datacenters to execute the application based, at least in part, on the cost associated with executing the application at the respective datacenter and executing the application at the selected datacenter.

Abstract: A system and method for datacenter power management is disclosed. In particular embodiments, the method includes receiving, with a processor, a request for execution of an application. The method also includes for each of a plurality of datacenters, determining an amount of electricity required to execute the application at the respective datacenter. The method also includes, for each of the plurality of datacenters, determining a cost associated with executing the application at the respective datacenter based, at least in part, on the amount of electricity required to execute the application at the respective datacenter. The method further includes selecting one of the plurality of datacenters to execute the application based, at least in part, on the cost associated with executing the application at the respective datacenter and executing the application at the selected datacenter.