Patents by Inventor ANDREW SANDHAM

ANDREW SANDHAM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
    Publication number: 20140336166
    Abstract: The invention relates to PI3K inhibitors of the formula (I) • in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.
    Type: Application
    Filed: October 26, 2012
    Publication date: November 13, 2014
    Applicant: NOVARTIS AG
    Inventors: Emmanuelle Briard, Pascal Furet, Andreas Lerchner, Peter Meier, Branko Radetich, David Andrew Sandham, Yanyi Zhu
  • PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS
    Publication number: 20140309254
    Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 16, 2014
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katharine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • Pyrrolopyridine derivatives and their use as CRTH2 antagonists
    Patent number: 8791256
    Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: July 29, 2014
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katharine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS
    Publication number: 20130267518
    Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: June 5, 2013
    Publication date: October 10, 2013
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katherine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • Organic compounds
    Patent number: 8470848
    Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: June 25, 2013
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katharine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • Pyrrolopyridine derivatives and their use as CRTH2 antagonists
    Patent number: 8455645
    Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: June 4, 2013
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katharine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • Pyrrolopyridine compounds and their use in treating disease
    Patent number: 8431703
    Abstract: There are provided according to the invention compounds of formula (I) in free ors salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: April 30, 2013
    Assignee: Novartis AG
    Inventors: David Andrew Sandham, Catherine Leblanc, Lyndon Nigel Brown
  • Organic compounds
    Patent number: 7888383
    Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: February 15, 2011
    Assignee: Novartis AG
    Inventor: David Andrew Sandham
  • Organic compounds
    Publication number: 20100210610
    Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: February 3, 2010
    Publication date: August 19, 2010
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katharine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • Organic compounds
    Publication number: 20100204225
    Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: February 3, 2010
    Publication date: August 12, 2010
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katharine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • Quinoline-2-one derivatives for the treatment of airways diseases
    Patent number: 7745462
    Abstract: Compounds of formula I in free or salt form, wherein —C—Y—, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the ?2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: June 29, 2010
    Assignee: Novartis AG
    Inventors: Robin Alec Fairhurst, David Andrew Sandham, David Beattie, Ian Bruce, Bernard Cuenoud, Reamonn Madden, Neil John Press, Roger John Taylor, Katharine Louise Turner, Simon James Watson
  • Organic compounds for the treatment of inflammatory or allergic conditions
    Patent number: 7678826
    Abstract: Compounds of formula (I) in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, R6, R7, m, n, w, X, and Y have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: March 16, 2010
    Inventors: Jake Axford, Urs Baettig, Brian Cox, Kamlesh Jagdis Bala, Catherine LeBlanc, David Andrew Sandham
  • Pyrrolopyridine derivatives and their use as Crth2 antagonists
    Patent number: 7666878
    Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R 4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: February 23, 2010
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Catherine Leblanc, David Andrew Sandham, Katharine Louise Turner, Simon James Watson, Lyndon Nigel Brown, Brian Cox
  • Organic Compounds
    Publication number: 20090221578
    Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: December 7, 2006
    Publication date: September 3, 2009
    Inventor: David Andrew Sandham
  • Organic Compounds
    Publication number: 20090209552
    Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R3, R4, R5, R6a, R6b, Q and W are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: June 11, 2007
    Publication date: August 20, 2009
    Inventors: David Andrew Sandham, Catherine Leblanc, Claire Adcock, Kamlesh Jagdis Bala, Maude Nadine Pierrette Pipet
  • COMBINATIONS OF STEROIDS AND METHYLXANTHINE COMPOUNDS
    Publication number: 20090018109
    Abstract: There is provided a medicament comprising a combination of a methylxanthine compound of formula I and a steroid of formula II and their use as pharmaceuticals, in particular for the treatment of inflammatory or obstructive airways diseases.
    Type: Application
    Filed: February 22, 2007
    Publication date: January 15, 2009
    Inventor: David Andrew Sandham
  • Organic Compounds
    Publication number: 20080312229
    Abstract: There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: December 7, 2006
    Publication date: December 18, 2008
    Inventors: David Andrew Sandham, Catherine Leblanc, Harinder Pal Singh, Lyndon Nigel Brown
  • Organic Compounds
    Publication number: 20080312322
    Abstract: A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.
    Type: Application
    Filed: May 22, 2006
    Publication date: December 18, 2008
    Inventors: Urs Baettig, Brian Cox, Katharine Louise Turner, Simon James Watson, Diana Janus, Catherine Leblanc, David Andrew Sandham
  • Organic Compounds
    Publication number: 20080312230
    Abstract: There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2R3R4, R5, R6, Q, X, m, n, and p are as described in the specification, on process for preparing them, and their use in the manufacture of a medicament for the treatment of neuropathic pain.
    Type: Application
    Filed: December 11, 2006
    Publication date: December 18, 2008
    Inventor: David Andrew Sandham
  • Organic Compounds
    Publication number: 20080287416
    Abstract: There are provided according to the invention compounds of formula (I) in free ors salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
    Type: Application
    Filed: December 7, 2006
    Publication date: November 20, 2008
    Inventors: David Andrew Sandham, Catherine Leblanc, Lyndon Nigel Brown