Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.

Abstract: In some implementations, a hydraulic coupling connection includes a coupling disposed at an end of a hose and defining a flange having: a lower surface configured to engage a body of a valve; an upper surface; and an outer diameter surface connecting the lower surface and the upper surface, the outer diameter surface defining a first plurality of straight sides; and a split flange engaged with the coupling, the split flange having: a first lower surface configured to engage the body of the valve; a second lower surface configured to engage the upper surface of the flange; and an inner diameter surface connecting the first lower surface and the second lower surface, the inner diameter surface defining a second plurality of straight sides, wherein engagement between the first plurality of straight sides and the second plurality of straight sides is configured to secure the connection at a first angle.

Abstract: In some implementations, a hydraulic coupling connection, defined between a hose and a valve of a machine, includes: a split flange configured to be engaged with a coupling disposed at an end of the hose; a plurality of fasteners disposed through corresponding openings in the split flange, wherein the plurality of fasteners are configured to secure the split flange and the coupling to a body of the valve; and a bracket secured with the split flange, via first and second fasteners, of the plurality of fasteners, disposed through corresponding openings in the bracket, wherein the bracket is configured to secure the connection at a first angle.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

Abstract: A routing assembly for routing an electrical connection between two or more sub-systems in a work machine includes a hose, a coupling member, a wiring harness, and a grommet. The hose defines a conduit. The coupling member defines a through-bore fluidly coupled with the conduit. The wiring harness facilitates passage of one or more electrical wirings through each of the conduit and the through-bore to enable electrical communication between the two or more sub-systems. The grommet is retentively engaged with the coupling member and the wiring harness respectively with a first force and a second force. The first force is greater than the second force facilitating a movement of the wiring harness with respect to the grommet without disengaging the grommet from the coupling member.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Abstract: A routing assembly for routing an electrical connection between two or more sub-systems in a work machine includes a hose, a coupling member, a wiring harness, and a grommet. The hose defines a conduit. The coupling member defines a through-bore fluidly coupled with the conduit. The wiring harness facilitates passage of one or more electrical wirings through each of the conduit and the through-bore to enable electrical communication between the two or more sub-systems. The grommet is retentively engaged with the coupling member and the wiring harness respectively with a first force and a second force. The first force is greater than the second force facilitating a movement of the wiring harness with respect to the grommet without disengaging the grommet from the coupling member.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.