Abstract: A sensor fabricated from a plurality of layers on a semiconductor wafer is described. The sensor comprises a plurality of sensor elements arranged in stitching blocks, wherein the plurality of stitching blocks comprise a plurality of vertically arranged control lines running from a bottom edge of the stitching block in the direction of an oppositely disposed top edge of the stitching block. One of the plurality of vertically arranged control lines terminates between the bottom edge and the top edge and the other ones of the plurality of vertically arranged control lines run from the bottom edge to the top edge and have a swerve at one of the bottom edge or the top edge, such that ones of the plurality of vertically arranged control lines in a first one of the plurality of stitching blocks connect to a displaced one of the vertical lines in a second abutting one of the plurality of stitching blocks.

Abstract: The present disclosure relates to methods for assessing metabolic flux. In some aspects, the disclosure relates to methods for estimating absolute metabolic flux for a pathway of interest based upon a level of one or more metabolites and/or isotopologues thereof at a single point in time following administration of a tracer to a subject. In some embodiments, the methods described herein are performed or generated using artificial intelligence/machine-learning (AI/ML) models.

Abstract: Cascading data replication for disaster recovery, including: establishing a cascading replication relationship between a plurality of storage nodes comprising a source endpoint node, a target endpoint node, and one or more intermediary nodes, wherein the cascading replication relationship comprises a chain of replication relationships between pairs of storage nodes from the source endpoint node to the target endpoint node via the one or more intermediary nodes; and replicating, based on the cascading replication relationship, a dataset from the source endpoint node to the target endpoint node via the one or more intermediary nodes.

Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I): where R1 is selected from hydrogen or an alkyl group having from 1 to about 16 carbon atoms; R2 is selected from a hydroxyl group, a tosylate group, an alkoxy group of the formula OR3 where R3 is selected from an alkyl group having from 1 to about 16 carbon atoms, or an ester group of the formula OCOR4, where R4 is an alkyl group having from 1 to about 16 carbon atoms, and n is from 4 to 46,000, with the proviso that when R1 is hydrogen and R2 is a hydroxy group the treatment compound has a number average molecular weight from 10,100 to 2,000,0000 g/mol.

Abstract: A imaging device according to the present disclosure comprises a pixel array comprising a plurality of pixels; a signal generator for generating an exposure timing scheme defining exposure durations for ones of the pixels grouped in at least one subgroup of the pixels, wherein ones of the exposure durations cover at least portions between a frame start time and a frame end time of predefined frame; a synchronizer for synchronizing a generation of a light pulse with the exposure timing scheme; and means for readout of charges accumulated in grouped ones of the pixels.

Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I), where the treatment compound is a random copolymer, R1 is selected from hydrogen and a hydroxyl group, R2 is selected from hydrogen and a hydroxyl group, R1 is different than R2, and a sum of x and y is from 4 to 20,000.

Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound formed by alkoxylation of an initiator using an oxide.

Abstract: An asset controller 1 is configured to selectively operate each of a plurality of fast-and slow-response assets 8, 9 in response to demand therefore, such that the slow-response asset 9 can be supported by a fast-response asset 8 at the start of a time-shift operation, to deliver the required response immediately and during the slow-response asset's 9 response time.

Abstract: The disclosure relates to active pixel sensors such as CMOS sensors. A sample stage of each pixel may comprise first and second sample switches in series between a buffer amplifier and a storage node. The first sample switch is connected to a column sample line, and the second sample switch is connected to a row sample line, such that an exposure signal is only passed to the storage node at a time when both a column sample signal and a row sample signal are active.

Abstract: The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of platelet derived growth factor C (PDGF-C). Such antibodies may be used for the modulation of PDGF-C activity in or secreted from a cell to study its effects on cell function and, in certain embodiments, for the treatment and/or prevention of a disease or condition associated with PDGF-C signing pathway.

Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I), where the treatment compound is a random copolymer, R1 is selected from hydrogen and a hydroxyl group, R2 is selected from hydrogen and a hydroxyl group, R1 is different than R2, and a sum of x and y is from 4 to 20,000.

Abstract: The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of platelet derived growth factor C (PDGF-C). Such antibodies may be used for the modulation of PDGF-C activity in or secreted from a cell to study its effects on cell function and, in certain embodiments, for the treatment and/or prevention of a disease or condition associated with PDGF-C signing pathway.

Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound formed by alkoxylation of an initiator using an oxide.

Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I): where R1 is selected from hydrogen or an alkyl group having from 1 to about 16 carbon atoms; R2 is selected from a hydroxyl group, a tosylate group, an alkoxy group of the formula OR3 where R3 is selected from an alkyl group having from 1 to about 16 carbon atoms, or an ester group of the formula OCOR4, where R4 is an alkyl group having from 1 to about 16 carbon atoms, and n is from 4 to 46,000, with the proviso that when R1 is hydrogen and R2 is a hydroxy group the treatment compound has a number average molecular weight from 10,100 to 2,000,0000 g/mol.

Abstract: The disclosure relates to active pixel sensors such as CMOS sensors. A sample stage of each pixel may comprise first and second sample switches in series between a buffer amplifier and a storage node. The first sample switch is connected to a column sample line, and the second sample switch is connected to a row sample line, such that an exposure signal is only passed to the storage node at a time when both a column sample signal and a row sample signal are active.

Abstract: The present invention relates, in part, to isolated antibodies that specifically interact with and show measurable binding affinity to an epitope of platelet derived growth factor C (PDGF-C). Such antibodies may be used for the modulation of PDGF-C activity in or secreted from a cell to study its effects on cell function and, in certain embodiments, for the treatment and/or prevention of a disease or condition associated with PDGF-C signing pathway.

Abstract: The invention relates to an apparatus and method for augmenting the 3 dimensional position information obtained from the NAVSTAR satellite-based global positioning system (“GPS”) system. Such systems can be impacted by physical obstacles that prevent the receipt of the satellite signals or as a result of sun spot activity that introduces noise into the signals thus causing them to become intermittently unavailable and/or making them less accurate in the course of normal operation. Therefore, an improved positioning solution that can operate under such poor GPS operational conditions is needed. The apparatus and method of the invention augments GPS with dead reckoning techniques when GPS signals are unavailable or inaccurate. The apparatus and method of the invention demonstrates highest value when applied to blasthole drill positioning applications in open-pit mines.

Abstract: The invention relates to an apparatus and method for augmenting the 3 dimensional position information obtained from the NAVSTAR satellite-based global positioning system (“GPS”) system. Such systems can be impacted by physical obstacles that prevent the receipt of the satellite signals or as a result of sun spot activity that introduces noise into the signals thus causing them to become intermittently unavailable and/or making them less accurate in the course of normal operation. Therefore, an improved positioning solution that can operate under such poor GPS operational conditions is needed. The apparatus and method of the invention augments GPS with dead reckoning techniques when GPS signals are unavailable or inaccurate. The apparatus and method of the invention demonstrates highest value when applied to blasthole drill positioning applications in open-pit mines.

Abstract: The invention relates to an apparatus and method for augmenting the 3 dimensional position information obtained from the NAVSTAR satellite-based global positioning system (“GPS”) system. Such systems can be impacted by physical obstacles that prevent the receipt of the satellite signals or as a result of sun spot activity that introduces noise into the signals thus causing them to become intermittently unavailable and/or making them less accurate in the course of normal operation. Therefore, an improved positioning solution that can operate under such poor GPS operational conditions is needed. The apparatus and method of the invention augments GPS with dead reckoning techniques when GPS signals are unavailable or inaccurate.

Abstract: A mounting system is provided including a center platform having a plurality of mounting lugs for mounting the center platform transversely extending at least partially through an aircraft cabin with a first end and second end of the center platform adjacent a respective first and second side opening of the aircraft cabin. A first support pylon may be removably coupleable to the first end of the center platform to extend outwardly from a first side of the aircraft. A second support pylon may be removably coupleable to the second end of the center platform to extend outwardly form a second side of the aircraft. A modular floor component may be removably coupleable relative to a longitudinal side of the center platform to provide a substantially planar load surface including a top portion of the modular floor component and a top surface of the center platform.