Patents by Inventor Andrew Scribner
Andrew Scribner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11759462Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: GrantFiled: March 15, 2021Date of Patent: September 19, 2023Inventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Publication number: 20210205305Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: March 15, 2021Publication date: July 8, 2021Applicant: Altavant Sciences GmbHInventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Patent number: 10946018Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: GrantFiled: April 16, 2020Date of Patent: March 16, 2021Assignee: Roivant Sciences GmbHInventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Patent number: 10738084Abstract: The invention relates to cyclic compounds of general formula (I): wherein R1, R2 and R3 are as defined in the specification, and their use as pharmaceuticals.Type: GrantFiled: June 30, 2016Date of Patent: August 11, 2020Assignee: Sentry Therapeutics LimitedInventors: Michael Peel, Andrew Scribner, Koichi Watashi, Satomi Shimura
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Publication number: 20200237760Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: April 16, 2020Publication date: July 30, 2020Applicant: Roivant Sciences GmbHInventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Patent number: 10660893Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: GrantFiled: May 30, 2019Date of Patent: May 26, 2020Assignee: ROIVANT SCIENCES, GmbHInventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Publication number: 20190282575Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: May 30, 2019Publication date: September 19, 2019Applicant: Altavant Sciences GmbHInventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Patent number: 10350208Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: GrantFiled: May 14, 2018Date of Patent: July 16, 2019Assignee: Roivant Sciences GmbHInventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Publication number: 20180256574Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: May 14, 2018Publication date: September 13, 2018Inventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Patent number: 10045988Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: GrantFiled: July 10, 2017Date of Patent: August 14, 2018Assignee: Roivant Sciences GmbHInventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Publication number: 20180186836Abstract: The invention relates to cyclic compounds of general formula (I): wherein R1, R2 and R3 are as defined in the specification, and their use as pharmaceuticals.Type: ApplicationFiled: June 30, 2016Publication date: July 5, 2018Applicant: Cypra;os LimitedInventors: Michael Peel, Andrew Scribner, Koichi Watashi, Satomi Shimura
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Publication number: 20180092918Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: July 10, 2017Publication date: April 5, 2018Inventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Publication number: 20180066523Abstract: An airfoil cooling system (54) for a gas turbine engine (10) is disclosed. The airfoil cooling system (54) may be formed from at least a first cooling fluid supply system (56), and a second cooling fluid supply system (58). The first cooling fluid supply system (56) may be configured to supply cooling fluids at a first pressure to one or more airfoils of a first row (68) of airfoils, and the second cooling fluid supply system (58) may be configured to supply cooling fluids at a second pressure to the one or more airfoils of the first row (68) of airfoils. Additionally, the second pressure may be lower than the first pressure. As such, each of the one or more airfoils may be cooled by cooling fluids at two different pressures. In particular embodiments, this may allow the airfoils to be cooled, while lowering the cost to the turbine engine (10) for providing such cooling.Type: ApplicationFiled: April 6, 2015Publication date: March 8, 2018Inventors: Jan H. Marsh, John J. Marra, Carmen Andrew Scribner
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Patent number: 9797259Abstract: A turbine airfoil cooling system including a low pressure cooling system and a high pressure cooling system for a turbine airfoil of a gas turbine engine is disclosed. In at least one embodiment, the low pressure cooling system may be an ambient air cooling system, and the high pressure cooling system may be a compressor bleed air cooling system. In at least one embodiment, the compressor bleed air cooling system in communication with a high pressure subsystem that may be a snubber cooling system positioned within a snubber. A delivery system including a movable air supply tube may be used to separate the low and high pressure cooling subsystems. The delivery system may enable high pressure cooling air to be passed to the snubber cooling system separate from low pressure cooling fluid supplied by the low pressure cooling system to other portions of the turbine airfoil cooling system.Type: GrantFiled: March 7, 2014Date of Patent: October 24, 2017Assignee: SIEMENS ENERGY, INC.Inventors: Jan H. Marsh, Stephen John Messmann, Carmen Andrew Scribner
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Patent number: 9797267Abstract: A turbine airfoil assembly for installation in a gas turbine engine. The airfoil assembly includes an endwall and an airfoil extending radially outwardly from the endwall. The airfoil includes pressure and suction sidewalls defining chordally spaced apart leading and trailing edges of the airfoil. An airfoil mean line is defined located centrally between the pressure and suction sidewalls. An angle between the mean line and a line parallel to the engine axis at the leading and trailing edges defines gas flow entry angles, ?, and exit angles, ?. Airfoil inlet and exit angles are substantially in accordance with inlet angle values, ?, and exit angle values, ?, set forth in one of Tables 1, 2, 3, and 4.Type: GrantFiled: November 24, 2015Date of Patent: October 24, 2017Assignee: SIEMENS ENERGY, INC.Inventors: Andrew S. Lohaus, Anthony J. Malandra, Carmen Andrew Scribner, Farzad Taremi, Horia Flitan, Ching-Pang Lee, Gm Salam Azad, Tobias Buchal
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Publication number: 20170095476Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: September 28, 2016Publication date: April 6, 2017Inventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Patent number: 9512122Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: GrantFiled: September 1, 2015Date of Patent: December 6, 2016Assignee: Karos Pharmaceuticals, Inc.Inventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Patent number: 9435212Abstract: A turbine airfoil usable in a turbine engine and having at least one snubber with a snubber cooling system positioned therein and in communication with an airfoil cooling system is disclosed. The snubber may extend from the outer housing of the airfoil toward an adjacent turbine airfoil positioned within a row of airfoils. The snubber cooling system may include an inner cooling channel separated from an outer cooling channel by an inner wall. The inner wall may include a plurality of impingement cooling orifices that direct impingement fluid against an outer wall defining the outer cooling channel. In one embodiment, the cooling fluids may be exhausted from the snubber, and in another embodiment, the cooling fluids may be returned to the airfoil cooling system. Flow guides may be positioned in the outer cooling channel, which may reduce cross-flow by the impingement orifices, thereby increasing effectiveness.Type: GrantFiled: November 8, 2013Date of Patent: September 6, 2016Assignee: Siemens Energy, Inc.Inventors: Carmen Andrew Scribner, Stephen John Messmann, Jan H. Marsh
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Publication number: 20160177723Abstract: A turbine airfoil assembly for installation in a gas turbine engine. The airfoil assembly includes an endwall and an airfoil extending radially outwardly from the endwall. The airfoil includes pressure and suction sidewalls defining chordally spaced apart leading and trailing edges of the airfoil. An airfoil mean line is defined located centrally between the pressure and suction sidewalls. An angle between the mean line and a line parallel to the engine axis at the leading and trailing edges defines gas flow entry angles, ?, and exit angles, ?. Airfoil inlet and exit angles are substantially in accordance with inlet angle values, ?, and exit angle values, ?, set forth in one of Tables 1, 2, 3, and 4.Type: ApplicationFiled: November 24, 2015Publication date: June 23, 2016Inventors: Andrew S. Lohaus, Anthony J. Malandra, Carmen Andrew Scribner, Farzad Taremi, Horia Flitan, Ching-Pang Lee, Gm Salam Azad, Tobias Buchal
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Publication number: 20160096836Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: September 1, 2015Publication date: April 7, 2016Inventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner