Abstract: The present disclosure provides various systems, diagnostic devices, and methods for nucleic acid analysis. The systems, devices, and methods allow for the analysis of nucleic acids, in a sample, via programmable nuclease-based assays. Provided are systems comprising an instrument and a cartridge allowing for point of care use. The systems, devices, and methods described herein can be configured for multiplexed detection of nucleic acids in a single sample.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe-Co alloy material (e.g., the Fe-Co-V alloy Hiperco-50(R)). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: A propellant storage system that utilizes an integrated internal lattice structure within the fuel storage tank(s) to provide additional strength and anti-slosh features. The internal lattice structure lends its additional strength properties to adapt the fuel storage tank to unconventional geometries to allow for better compaction and weight savings in deployment vehicles such as satellites.

Abstract: Systems and methods of additively manufacturing multi-material electromagnetic shields are described. Additive manufacturing processes use co-deposition to incorporate multiple materials and/or microstructures selected to achieve specified shield magnetic properties. Geometrically complex shields can be manufactured with alternating shielding materials optimized for the end use application. The microstructures of the printed shields can be tuned by optimizing the print parameters.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe-Co alloy material (e.g., the Fe-Co-V alloy Hiperco-50(R)). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: In some embodiments, high-energy additive manufacturing (HE-AM) (e.g., directed energy deposition, powder injection, powder bed fusion, electron beam melting, solid-state, and ultrasonic) is used to overcome constraints of comparative EES fabrication techniques to produce chemical additive-free electrodes with complex, highly versatile designs for next generation EES. An exemplary rapid fabrication technique provides an approach for improving electrochemical performance while increasing efficiency and sustainability, reducing time to market, and lowering production costs. With this exemplary technique, which utilizes computer models for location specific layer-by-layer fabrication of three-dimensional parts (e.g., versatile design), a high degree of control over processing conditions may be achieved to enhance both the design and performance of EES systems.

Abstract: Systems and methods of additively manufacturing multi-material electromagnetic shields are described. Additive manufacturing processes use co-deposition to incorporate multiple materials and/or microstructures selected to achieve specified shield magnetic properties. Geometrically complex shields can be manufactured with alternating shielding materials optimized for the end use application. The microstructures of the printed shields can be tuned by optimizing the print parameters.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe—Co alloy material (e.g., the Fe—Co—V alloy Hiperco-50®). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: Printed textiles and related manufacturing methods are provided. Textile materials can include laced mesh fabrics made of rigid components. The laced mesh structures are designed for space applications, including but not limited to adaptive and foldable reflectors, capturing systems, debris and micrometeorite shielding, shading systems, sample capturing, and various other applications. The laced mesh structures are used in the generation of tailored, unique radio-frequency antennas and receivers that allow for active tuning/receiving capabilities. The tailored structure can also include multi-material systems mixing dielectric and conductive layers for enhanced, tunable transmission. Laced mesh structures can also be used for enhanced thermal control of components, with the ability to tailor thermal conductivity and emissivity, to create thermal engineered components via the generation of localized or global thermal response (e.g. zone thermal control).

Abstract: In some embodiments, high-energy additive manufacturing (HE-AM) (e.g., directed energy deposition, powder injection, powder bed fusion, electron beam melting, solid-state, and ultrasonic) is used to overcome constraints of comparative EES fabrication techniques to produce chemical additive-free electrodes with complex, highly versatile designs for next generation EES. An exemplary rapid fabrication technique provides an approach for improving electrochemical performance while increasing efficiency and sustainability, reducing time to market, and lowering production costs. With this exemplary technique, which utilizes computer models for location specific layer-by-layer fabrication of three-dimensional parts (e.g., versatile design), a high degree of control over processing conditions may be achieved to enhance both the design and performance of EES systems.

Abstract: A propellant storage system that utilizes an integrated internal lattice structure within the fuel storage tank(s) to provide additional strength and anti-slosh features. The internal lattice structure lends its additional strength properties to adapt the fuel storage tank to unconventional geometries to allow for better compaction and weight savings in deployment vehicles such as satellites.

Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe—Co alloy material (e.g., the Fe—Co—V alloy Hiperco-50®). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.

Abstract: A computer-implemented system and methods for enabling a user or users to select and prioritize a set of criteria are disclosed. Various example embodiments can be configured to enable users to express the relative importance of their preferences with respect to a set of options and that is employed by a process to identify options and generate combinations of options, to filter and rank the set of options or combinations of options with respect to the set of criteria, and to present the options or combinations of options that best fit the expressed criteria to the users.

Abstract: Systems and methods including computing patterns of visitation to predefined regions by converting coordinates of mobile devices to cell identifiers and searching a database to find matches between cell identifiers representing regions and the cell identifiers of the device locations. Devices having similar visitation patterns are divided into two groups, based on status data of whether or not information about a region has been transmitted to respective users. The visitation patterns after the transmission are compared by a system between the two groups to measure a difference. Identifiers of devices, users, or households are initially provided to the system without the status data to obtain attributes associated individually with the identifiers. In return, the system is provided with the status data associated with the attributes individually for the devices, users, or households but without sufficient information to map the status data individually to the identifiers of the devices, users, or households.

Abstract: Printed textiles and related manufacturing methods are provided. Textile materials can include laced mesh fabrics made of rigid components. The laced mesh structures are designed for space applications, including but not limited to adaptive and foldable reflectors, capturing systems, debris and micrometeorite shielding, shading systems, sample capturing, and various other applications. The laced mesh structures are used in the generation of tailored, unique radio-frequency antennas and receivers that allow for active tuning/receiving capabilities. The tailored structure can also include multi-material systems mixing dielectric and conductive layers for enhanced, tunable transmission. Laced mesh structures can also be used for enhanced thermal control of components, with the ability to tailor thermal conductivity and emissivity, to create thermal engineered components via the generation of localized or global thermal response (e.g. zone thermal control).

Abstract: Systems and methods including computing patterns of visitation to predefined regions by converting coordinates of mobile devices to cell identifiers and searching a database to find matches between cell identifiers representing regions and the cell identifiers of the device locations. Devices having similar visitation patterns are divided into two groups, based on status data of whether or not information about a region has been transmitted to respective users. The visitation patterns after the transmission are compared by a system between the two groups to measure a difference. Identifiers of devices, users, or households are initially provided to the system without the status data to obtain attributes associated individually with the identifiers. In return, the system is provided with the status data associated with the attributes individually for the devices, users, or households but without sufficient information to map the status data individually to the identifiers of the devices, users, or households.

Abstract: Systems and methods including computing patterns of visitation to predefined regions by converting coordinates of mobile devices to cell identifiers and searching a database to find matches between cell identifiers representing regions and the cell identifiers of the device locations. Devices having similar visitation patterns are divided into two groups, based on status data of whether or not information about a region has been transmitted to respective users. The visitation patterns after the transmission are compared by a system between the two groups to measure a difference. Identifiers of devices, users, or households are initially provided to the system without the status data to obtain attributes associated individually with the identifiers. In return, the system is provided with the status data associated with the attributes individually for the devices, users, or households but without sufficient information to map the status data individually to the identifiers of the devices, users, or households.

Abstract: Systems and methods including computing patterns of visitation to predefined regions by converting coordinates of mobile devices to cell identifiers and searching a database to find matches between cell identifiers representing regions and the cell identifiers of the device locations. Devices having similar visitation patterns are divided into two groups, based on status data of whether or not information about a region has been transmitted to respective users. The visitation patterns after the transmission are compared by a system between the two groups to measure a difference. Identifiers of devices, users, or households are initially provided to the system without the status data to obtain attributes associated individually with the identifiers. In return, the system is provided with the status data associated with the attributes individually for the devices, users, or households but without sufficient information to map the status data individually to the identifiers of the devices, users, or households.

Abstract: A turbine blade for a gas turbine engine comprises an airfoil having a pressure side, a suction side, a span direction and a chord-wise direction. The airfoil has an airfoil span on a pressure line being a projection of the stacking line onto the pressure side. The airfoil has a plurality of chords extending between a leading edge and a trailing edge of the airfoil. A generally round dimple is disposed on the pressure side. The dimple is contained in an area extending on the stacking line between 0% and 23% of the airfoil span from the inner end, and in the chord-wise direction between 0% of a first chord and 82% of a second chord from the leading edge. The dimple is configured to initiate fracture of the blade at a predetermined speed of rotation. A method of preventing rupture of a disk of a turbine rotor is also presented.

Abstract: An apparatus and method for vibration suppression using a granular particle chain. The granular particle chain is statically compressed and the end particles of the chain are attached to a payload and vibration source. The properties of the granular particles along with the amount of static compression are chosen to provide desired filtering of vibrations.