Abstract: The present disclosure relates, generally, to compositions and methods for producing, purifying, and using circular RNA.

Abstract: The present invention relates to a group of resorcinol derivatives as a pharmaceutically active compounds and methods of preparation thereof. Resorcinol derivatives have been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the resorcinol derivative of the invention.

Abstract: Disclosed herein are viroid-derived polynucleotides for the modification of plants and methods of using such polynucleotides in a variety of agricultural and commercial methods. Specifically, the disclosure provides a method of delivering to a plant a composition comprising a recombinant polynucleotide comprising: (i) a single-stranded RNA (ssRNA) viroid sequence and (ii) a heterologous RNA sequence comprising or encoding an effector, wherein the effector has a biological effect on the plant, and wherein the viroid is potato spindle tuber viroid (PSTVd) or eggplant latent viroid (ELVd).

Abstract: The present invention relates to a resorcinol derivative as a pharmaceutically active compound and method of preparation thereof. Resorcinol derivatives have been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the resorcinol derivative of the invention.

Abstract: The present invention relates to a cannabinoid derivative as a pharmaceutically active compound and method of preparation thereof. The cannabinoid derivative of the invention is an analogue of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the cannabinoid derivative of the invention.

Abstract: The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of novel cannabidiol compounds.

Abstract: The system provides a method and apparatus for tracking and managing insurance coverage for an enterprise. In one embodiment, the system provides automated reports that include all types of coverage in a single report with a visual representation that fully informs the reader of status and areas of risk and concern. The reports are fully sortable and can provide a single resource for management of all policies and coverages of an enterprise. In one embodiment the system presents data in a unique grid that provides important information at a glance and enhances management of the system.

Abstract: Disclosed herein are new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Abstract: A photon detection device and method of fabricating a photon detection device are provided. The photon detection device comprises a first input terminal for receiving a DC input voltage, a second input terminal for receiving an AC input voltage and a bias tee connected to the first and second input terminals and configured to combine the AC and DC input voltages to form a combined voltage on an output of the bias tee. A first single photon detector is connected to the output of the bias tee and configured to receive the combined voltage from the bias tee, register a detection signal based on only a single photon being incident on the first single photon detector and output the detection signal indicative of the detected photon. A first output terminal is connected to an output of the first single photon detector for outputting the detection signal. The photon detection device is formed in a single integrated circuit.

Abstract: The system provides a method and apparatus for tracking and managing insurance coverage for an enterprise. In one embodiment, the system provides automated reports that include all types of coverage in a single report with a visual representation that fully informs the reader of status and areas of risk and concern. The reports are fully sortable and can provide a single resource for management of all policies and coverages of an enterprise. In one embodiment the system presents data in a unique grid that provides important information at a glance and enhances management of the system.

Abstract: A method of workflow management in a cloud computing system that includes generating a workflow graph from a workflow definition, the workflow graph including nodes representing work-elements; generating a stream matrix from the workflow graph, the stream matrix including pointers to lists of the work-elements, each of the lists representing a workstream; processing the stream matrix to place work-elements in a platform service pipeline for the cloud computing system based on resource availability of the platform service pipeline; and removing work-elements from the lists and the platform service pipeline upon completion.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A photon detection device and method of fabricating a photon detection device are provided. The photon detection device comprises a first input terminal for receiving a DC input voltage, a second input terminal for receiving an AC input voltage and a bias tee connected to the first and second input terminals and configured to combine the AC and DC input voltages to form a combined voltage on an output of the bias tee. A first single photon detector is connected to the output of the bias tee and configured to receive the combined voltage from the bias tee, register a detection signal based on only a single photon being incident on the first single photon detector and output the detection signal indicative of the detected photon. A first output terminal is connected to an output of the first single photon detector for outputting the detection signal. The photon detection device is formed in a single integrated circuit.

Abstract: A method of workflow management in a cloud computing system that includes generating a workflow graph from a workflow definition, the workflow graph including nodes representing work-elements; generating a stream matrix from the workflow graph, the stream matrix including pointers to lists of the work-elements, each of the lists representing a workstream; processing the stream matrix to place work-elements in a platform service pipeline for the cloud computing system based on resource availability of the platform service pipeline; and removing work-elements from the lists and the platform service pipeline upon completion.

Abstract: A photon detection device and method of fabricating a photon detection device are provided. The photon detection device comprises a first input terminal for receiving a DC input voltage, a second input terminal for receiving an AC input voltage and a bias tee connected to the first and second input terminals and configured to combine the AC and DC input voltages to form a combined voltage on an output of the bias tee. A first single photon detector is connected to the output of the bias tee and configured to receive the combined voltage from the bias tee, register a detection signal based on only a single photon being incident on the first single photon detector and output the detection signal indicative of the detected photon. A first output terminal is connected to an output of the first single photon detector for outputting the detection signal. The photon detection device is formed in a single integrated circuit.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: An apparatus for the wafer level packaging (WLP) of micro-bolometer vacuum package assemblies (VPAs), in one embodiment, includes a wafer alignment and bonding chamber, a bolometer wafer chuck and a lid wafer chuck disposed within the chamber in vertically facing opposition to each other, means for creating a first ultra-high vacuum (UHV) environment within the chamber, means for heating and cooling the bolometer wafer chuck and the lid wafer chuck independently of each other, means for moving the lid wafer chuck in the vertical direction and relative to the bolometer wafer chuck, means for moving the bolometer wafer chuck translationally in two orthogonal directions in a horizontal plane and rotationally about a vertical axis normal to the horizontal plane, and means for aligning a fiducial on a bolometer wafer held by the bolometer wafer chuck with a fiducial on a lid wafer held by the lid wafer chuck.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.

Abstract: The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).