Abstract: Hydroxylated nebivolol metabolites increase NO release from human endothelial cell preparations in a concentration dependent fashion following acute administration. In addition, hydroxylated nebivolol metabolites, including but not limited to 4-hydroxy-6,6?difluoro-, 4-hydroxy-5-phenol-6,6?difluoro-, and 4-hydroxy-8-pheno-6,6?difluoro-, have the ability to increase the capacity for NO release in human endothelial cells following chronic administration. This invention provides hydroxylated nebivolol metabolites and compositions comprising nebivolol and/or at least one hydroxylated metabolite of nebivolol and/or at least one additional compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof.

Abstract: This invention provides glucuronidated nebivolol metabolites and pharmaceutical compositions of glucuronidated nebivolol metabolites for treatment of cardiovascular diseases. In addition, this invention also provides compositions comprising nebivolol and/or at least one glucuronidated metabolite of nebivolol and/or at least one other active compound in a pharmaceutically acceptable carrier. This invention also provides methods of treating and/or preventing vascular diseases, by administering at least one glucuronidated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease. Also, this invention is directed to the treatment and/or prevention of migraine headaches administering at least one glucuronidated metabolite of nebivolol. This invention may also be used in conjunction with or as a single treatment of metabolic syndrome disorders.

Abstract: Modified target molecules are disclosed comprising genetically modified molecules, preferably enzymes, that include a catalytic triad which alters the performance of the polypeptide. Optionally, such a catalytic triad in the modified target molecule comprises three members equivalent to amino acid residues Serine 227, Histidine 200, or Glutamate 139, respectively, in the Bacillus cellulase 103 sequence. Using the embodiments disclosed by the present invention, altered performance profiles, such as enzyme activity or stability, under alkaline conditions can be achieved. Methods of making and using modified target molecules are also disclosed.

Abstract: This invention is generally concerned with sensing apparatus and methods, more particularly apparatus and methods for sensing techniques based upon cavity ring-down spectroscopy (CRDS). An evanescent wave cavity-based optical sensor is described.

Abstract: In a computer system that translates target instructions from a target instruction set into host instructions from a host instruction set, a method for checking a sequence of target instructions for changes. The method includes testing whether the target instructions at a memory location have changed subsequent to the translating by examining a bit indicator associated with the memory location and determining whether the testing is slowing the operation of the computer system. If the testing is slowing the operation of the computer system, a checking process initiated, which includes storing a copy of the sequence of target instructions and comparing the copy with the sequence of target instructions.

Abstract: A method of forming interconnections between channels and/or chambers for use in a micro-fluidic device. Two planer substrates (usually glass and silicon respectively) having etched channels are bonded together to form volmes where the channels overlap. A manifolding cut is then made through the glass, intersecting glass channels only. An organic solution is passed into cut, and flows through silicon channels. An aqueous solution is passed into cut, and flows through glass channels. The solutions meet in the region, where matter is transferred from one solution to another.

Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.

Abstract: In a client-server architecture, data transmission performance enhancing features and mechanisms are described, including a color quality approach and a packet shaping approach. A method includes a color quality data transformation including: selecting a quality level to apply to a set of image data having a number of significant color bits defining an initial number of possible colors; applying a pixel mask to the set of image data, the initial number of possible colors reduced to a smaller number of possible colors as a function of the quality level; loading the set of image data into an output buffer; and sending the set of image data from the output buffer to a display engine.

Abstract: In a client-server architecture, data transmission performance enhancing features are described, including a color quality approach and a packet shaping approach. A method includes a color quality data transformation including: selecting a quality level to apply to a set of image data having a number of significant color bits defining an initial number of possible colors; applying a pixel mask to the set of image data, the initial number of possible colors reduced to a smaller number of possible colors as a function of the quality level; loading the set of image data into an output buffer; and sending the set of image data from the output buffer to a display engine.

Abstract: This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.

Abstract: This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.

Abstract: A method of forming a fluid tight seal between a first fluid pathway and a second fluid pathway a volume is defined between an outer surface of the first fluid pathway and an inner surface of the second fluid pathway. The surfaces are maintained in a given orientation and distance with respect, one to another, so as to achieve a desired capillaric property therebetween. A quantity of sealant is delivered to a junction region of said surfaces. The sealant is caused or permitted to flow into the defined volume, so as to achieve capillary balance. Only substantially sufficient sealant is delivered to fill the volume. The sealant is then caused or permitted to cure or set.

Abstract: A cavity ring-down spectroscopy system and method is provided for detecting and resolving the ring-down pulse-by-pulse. The pulse-by-pulse cavity ring-down spectroscopy system enables for measuring absorption spectra of rapidly evolving systems on the order of the roundtrip time. The pulse-by-pulse analysis of ring-down profiles enables non-exponential ring-down absorption dynamics to be determined.

Abstract: The invention relates to an optical assembly for opto-electronic packages comprising an optical fibre secured on the underside of an elongated support member in optical alignment with an opto-electronic device, wherein said support member is affixed to an aligning member, which in turn is affixed, e.g., by laser welding, to a welding platform. In a preferred embodiment, the elongated support member is a planar parallelepiped. In a further preferred embodiment, the elongated support member is a parallelepiped with an axially extended slot, in which the optical fibre is secured with its longitudinal axis substantially parallel to the axially extended slot.

Abstract: An adaptor for receiving a fluidic device (12) and facilitating connection of the device (12) to a similar device or other object, the device having defined therein at least one fluid pathway (24), the adaptor being capable of receiving fluid from said at least one pathway (24) and having connecting means (28) for connecting to the, or each fluid pathway (24), so as to substantially immobilise the pathway(s) with respect to the device, thereby preventing damage to the pathway(s), the means for connecting each pathway provides a fluid tight seal, so that in use fluid passes to/from the device, without leakage, to a similar device.

Abstract: A method for maintaining consistency between translated host instructions and target instructions from which the host instructions have been translated including the steps of maintaining a copy of a target instruction for which a translated host instruction have been made, comparing the copy of the target instruction with a target instruction at a memory address at which the target instruction from which the copy was made was stored when translated, disabling the translated host instruction if the copy of the target instruction is not the same as the target instruction at the memory address, and executing the translated host instruction if the copy of the target instruction is the same as the target instruction at the memory address.

Abstract: The present invention relates to novel variant EGIII or EGIII-like cellulases which have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.

Abstract: The present invention is directed to the use of betaine or its physiologically acceptable salt for enhancing endurance during exercise, enhancing muscle mass and reducing muscle soreness and muscle fatigue. It is also directed to the use of betaine or its physiologically acceptable salt for enhancing the flavor of a food or beverage.

Abstract: Various polysaccharides are prepared by reacting glucose or glucose-containing materials such as hydrolyzed starch with a polyol such as sorbitol in the presence of mineral acids such as phosphoric, hydrochloric and/or sulfuric acid. In one embodiment, polydextrose is prepared by reacting glucose or glucose-containing materials such as hydrolyzed starch with a polyol such as sorbitol in the presence of low levels, i.e., from about 0.001% to about 0.09%, more narrowly from about 0.01% to about 0.06%, phosphoric acid. In other embodiments, other mineral acids or mixtures thereof may be employed. In alternate embodiments, a combination of mineral and organic carboxylic acids such as citric acid are employed. Because of the low levels of catalyst used in certain preferred embodiments, minimal or no off-flavors and little color are formed during the course of the reaction.

Abstract: In a client-server architecture, data transmission performance enhancing features and mechanisms are described, including a color quality approach and a packet shaping approach. A method includes a color quality data transformation including: selecting a quality level to apply to a set of image data having a number of significant color bits defining an initial number of possible colors; applying a pixel mask to the set of image data, the initial number of possible colors reduced to a smaller number of possible colors as a function of the quality level; loading the set of image data into an output buffer; and sending the set of image data from the output buffer to a display engine.