Patents by Inventor Andrew SIKORA

Andrew SIKORA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MATERIALS AND METHODS RELATING TO IMMUNOGENIC EPITOPES FROM HUMAN PAPILLOMAVIRUS
    Publication number: 20250073325
    Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.
    Type: Application
    Filed: March 6, 2024
    Publication date: March 6, 2025
    Inventors: Sri KRISHNA, Marshall POSNER, Andrew SIKORA, Karen ANDERSON
  • MATERIALS AND METHODS RELATING TO IMMUNOGENIC EPITOPES FROM HUMAN PAPILLOMAVIRUS
    Publication number: 20230143555
    Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.
    Type: Application
    Filed: October 14, 2022
    Publication date: May 11, 2023
    Inventors: Sri KRISHNA, Marshall POSNER, Andrew SIKORA, Karen ANDERSON
  • Materials and methods relating to immunogenic epitopes from human papillomavirus
    Patent number: 11524063
    Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: December 13, 2022
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, BAYLOR COLLEGE OF MEDICINE
    Inventors: Sri Krishna, Marshall Posner, Andrew Sikora, Karen Anderson
  • ONCOLYTIC VIROTHERAPY AND IMMUNOTHERAPY
    Publication number: 20220387530
    Abstract: The present disclosure concerns combination therapy for cancer thatutilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.
    Type: Application
    Filed: November 7, 2019
    Publication date: December 8, 2022
    Applicant: Baylor College of Medicine
    Inventors: Masataka Suzuki, Amanda Rosewell Shaw, Caroline Elaine Porter, Norihiro Watanabe, Malcolm K. Brenner, Andrew Sikora
  • Immune stimulatory function and anti-tumor activity of TGF-? primed myeloid derived suppressor cells (MDSC)
    Patent number: 11090333
    Abstract: Embodiments of the disclosure concern methods and compositions related to cancer therapy using myeloid derived suppressor cells (MDSC) as a solo therapy or an adjunct therapy. The MDSCs are prepared by exposing bone marrow cells or blood cells to one or more compositions that induce their differentiation to MDSCs and also to TGF-?1, and in specific embodiments the exposure to TGF-?1 results in the MDSCs having anti-tumor activity and/or immune stimulatory activity.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: August 17, 2021
    Assignee: Baylor College of Medicine
    Inventors: Andrew Sikora, Padmini Jayaraman, Falguni Parikh, Robin Parihar
  • MATERIALS AND METHODS RELATING TO IMMUNOGENIC EPITOPES FROM HUMAN PAPILLOMAVIRUS
    Publication number: 20210205435
    Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+HNSCC-specific checkpoints for targeted immunotherapy.
    Type: Application
    Filed: November 15, 2018
    Publication date: July 8, 2021
    Inventors: Sri KRISHNA, Marshall POSNER, Andrew SIKORA, Karen ANDERSON
  • IMMUNE STIMULATORY FUNCTION AND ANTI-TUMOR ACTIVITY OF TGF-ß PRIMED MYELOID DERIVED SUPPRESSOR CELLS (MDSC)
    Publication number: 20190046569
    Abstract: Embodiments of the disclosure concern methods and compositions related to cancer therapy using myeloid derived suppressor cells (MDSC) as a solo therapy or an adjunct therapy. The MDSCs are prepared by exposing bone marrow cells or blood cells to one or more compositions that induce their differentiation to MDSCs and also to TGF-?1, and in specific embodiments the exposure to TGF-?1 results in the MDSCs having anti-tumor activity and/or immune stimulatory activity.
    Type: Application
    Filed: September 14, 2016
    Publication date: February 14, 2019
    Applicant: Baylor College of Medicine
    Inventors: Andrew SIKORA, Padmini JAYARAMAN, Falguni PARIKH, Robin PARAHIR