Patents by Inventor Andrew Simon Brearley

Andrew Simon Brearley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Publication number: 20230286978
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: April 7, 2021
    Publication date: September 14, 2023
    Inventors: Jonathan Bentley, Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Publication number: 20230271957
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: April 7, 2021
    Publication date: August 31, 2023
    Inventors: Jonathan Bentley, JR., Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • Inhibitors of SARM1
    Publication number: 20230008433
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: August 17, 2021
    Publication date: January 12, 2023
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Sophie Catherine COOPER, Rajesh DEVRAJ, Robert Owen HUGHES, Richard Andrew JARJES-PIKE, Frederic Jacques MARLIN, Shelley Anne PARROTT, Daniel SILVA
  • INHIBITORS OF SARM1
    Publication number: 20220340546
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 27, 2022
    Inventors: Robert Owen HUGHES, Rajesh DEVRAJ, Todd BOSANAC, Richard Andrew JARJES-PIKE, Andrew Simon BREARLEY, Jonathan BENTLEY, Shelley Anne PARROTT, Sophie Catherine COOPER
  • INHIBITORS OF SARM1
    Publication number: 20220315568
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 6, 2022
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Rajesh DEVRAJ, Robert Owen HUGHES
  • INHIBITORS OF SARM1
    Publication number: 20220194933
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: June 6, 2019
    Publication date: June 23, 2022
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • Inhibitors of SARM1
    Publication number: 20220056013
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: August 23, 2021
    Publication date: February 24, 2022
    Inventors: Todd BOSANAC, Andrew Simon BREARLEY, Rajesh DEVRAJ, Robert Owen HUGHES, Richard Andrew JARJES-PIKE, Shelley Anne PARROTT
  • INHIBITORS OF SARM1
    Publication number: 20210261540
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).
    Type: Application
    Filed: June 6, 2019
    Publication date: August 26, 2021
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • INHIBITORS OF SARM1
    Publication number: 20210261537
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI).
    Type: Application
    Filed: June 6, 2019
    Publication date: August 26, 2021
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley