Abstract: In one preferred aspect, a method is provided for inserting an instrument set having a tapered configuration into a patient. In another preferred aspect, a method is provided for inserting a cannula having an external threaded portion into bone. In yet another preferred aspect, a method is provided for forming and enlarging an opening in bone.

Abstract: An implant for placing in the spine is disclosed. The implant has a tool engaging surface on its trailing end configured for intimate engagement with an insertion tool. The insertion tool configuration is particularly suited for implants made of brittle materials including bone and bone substitutes. Also disclosed is an insertion tool having a gripping end adapted for intimate engagement with an implant. In one embodiment, the insertion tool is operable by axial movement of one gripping arm with respect to the other.

Abstract: An instrument set is provided that has a tapered configuration that facilitates the insertion of the instrument set into a patient.

Abstract: The disclosure is directed to a needle system configured to enlarge an access path in a patient without further cutting into the tissue of the patient so as to reduce recovery time and trauma to the patient. Also provided are methods of using the needle system provided.

Abstract: In one preferred aspect, a method is provided for forming an opening in bone for the sequential dilation of tissue.

Abstract: The invention relates to a bioactive settable hydrogel matrix having a pore creating material, which may also carry a therapeutic agent, and methods of using the same, for example, use in promoting internal wound healing, tissue repair, tissue regeneration.

Abstract: The invention relates to a biocompatible settable polymer useful in retaining an implant, more evenly distributing any force loading on the implant, and/or promoting tissue growth around and onto the implant.

Abstract: A guide and a blade for contouring vertebral bodies. The guide is sized to be mounted between two vertebral members and includes a pair of edges for receiving the blade. The pair of edges are spaced a distance apart for the first edge to align with a first vertebral member, and the second edge to align with a second vertebral member. The blade includes a pair of arms with at least one cutting edge. The arms are sized to fit within the pair of edges respectively. Using the blade and guide comprises inserting the guide adjacent to two vertebral members, and inserting the arms through the pair of edges to contour the ends of the members. In an embodiment with cutting edges at the distal ends of each of the arms, the two vertebral members can be contoured simultaneously.

Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of bone pieces formed into at least one load bearing layer.

Abstract: A method is disclosed for increasing the stiffness of an intervertebral disc between vertebral bodies. The method includes providing a syringe with a needle approximately in the range of 16 to 25 gauge; providing a material having a first stage with a first viscosity adapted to flow through the needle, the material having a second stage with a second viscosity greater than the first viscosity, the second stage material having a stiffness in a range of 1.0-5.0 MPa; testing the annulus fibrosus of the disc to ensure that the annulus fibrosus has sufficient continuity so as to retain the first flowable stage material when subsequently injected into the disc; inserting the needle into the annulus fibrosus; injecting the first stage material into the disc; and permitting the first stage material to become the second stage material so as to form a load bearing implant in the disc.

Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of pieces of bone and a flexible mechanism including one or more flexible, elongate, biocompatible connectors interconnecting the pieces of bone.

Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises at least one structural member combined with at least one flexible planar member to retain the at least one structural member to form the implant.

Abstract: An implant for placing in the spine is disclosed. The implant has a tool engaging surface on its trailing end configured for intimate engagement with an insertion tool. The insertion tool configuration is particularly suited for implants made of brittle materials including bone and bone substitutes. Also disclosed is an insertion tool having a gripping end adapted for intimate engagement with an implant. In one embodiment, the insertion tool is operable by axial movement of one gripping arm with respect to the other.

Abstract: A guide and a blade for contouring vertebral bodies. The guide is sized to be mounted between two vertebral members and includes a pair of edges for receiving the blade. The pair of edges are spaced a distance apart for the first edge to align with a first vertebral member, and the second edge to align with a second vertebral member. The blade includes a pair of arms with at least one cutting edge. The arms are sized to fit within the pair of edges respectively. Using the blade and guide comprises inserting the guide adjacent to two vertebral members, and inserting the arms through the pair of edges to contour the ends of the members. In an embodiment with cutting edges at the distal ends of each of the arms, the two vertebral members can be contoured simultaneously.

Abstract: Techniques and systems for distracting a spinal disc space and supporting adjacent vertebrae are provided. Trial instruments are insertable into the disc space to determine a desired disc space height and to select a corresponding implant. Implants can be also be self-distracting and the implant providing the desired disc space height can be implanted in the spinal disc space.

Abstract: A modular intervertebral prosthesis system includes first and second baseplates and an insert designed to mate to the baseplates. The baseplates include a mounting section and a intervertebral section extending away from the mounting section generally perpendicular thereto. The intervertebral section has at least one aperture passing therethrough. When installed, the insert is disposed between the intervertebral sections of the baseplates and faces the apertures. In this way, the insert is not insulated from the vertebral members, thereby allowing for osteoinduction, osteoconduction, and/or osteointegration, if desired. The insert may take the form of an articulating-type insert or a fusion-type insert, with the baseplates being operative with both types of inserts. After installation of the insert between the baseplates, the insert may be readily removed, at least initially.

Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of bone pieces formed into at least one load bearing layer.

Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of pieces of bone and a flexible mechanism including one or more flexible, elongate, biocompatible connectors interconnecting the pieces of bone.

Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises at least one structural member combined with at least one flexible planar member to retain the at least one structural member to form the implant.

Abstract: Techniques and systems for distracting a spinal disc space and supporting adjacent vertebrae are provided. Trial instruments are insertable into the disc space to determine a desired disc space height and to select a corresponding implant. Implants can be also be self-distracting and the implant providing the desired disc space height can be implanted in the spinal disc space.