Abstract: The present invention relates to a retroviral vector system comprising a therapeutic gene wherein said retroviral vector system is pseudotyped with at least part of a heterologous envelope protein or a mutant, variant or homologue thereof and wherein said therapeutic gene is downstream of an internal promoter.

Abstract: A compound of formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, and their use in treating diseases ameliorated by the inhibition of ATM.

Abstract: The present invention discloses synthetic oligonucleotides complementary to contiguous and noncontiguous regions of the HBV RNA. Also disclosed are methods and kits for inhibiting the replication and expression of HBV, and for treating HBV infections and associated conditions.

Abstract: A magnetic field generating assembly comprises a magnetic field generation system (7, 8) for generating, in a first mode, a first, relatively strong static magnetic field in a working volume (71) located outside the assembly, and for generating, in a second mode, a second, static magnetic field in the working volume in a second mode. In the second mode the magnetic field in the working volume (71) is weaker but more uniform than the first relatively strong magnetic field.

Abstract: The present invention relates to a retroviral vector system comprising a therapeutic gene wherein said retroviral vector system is pseudotyped with at least part of a heterologous envelope protein or a mutant, variant or homologue thereof and wherein said therapeutic gene is downstream of an internal promoter.

Abstract: An NMR sensor including a magnetic field generating assembly, an RF antenna, and a plurality of ferrite members which couple with RF magnetic fields transmitted or received by the RF antenna. The sensor is typically used in apparatus for performing borehole measurements.

Abstract: An rf magnetic field pulse generator for generating a pulse train comprising a plurality of rf magnetic field pulses for use in an NMR investigation, the generator comprising(i) an amplifier (5) for generating an rf signal, the amplifier having an input for receiving a supply voltage;(ii) a transmitter coil (42) connected to an output of the amplifier, the transmitter coil being adapted to transmit the rf magnetic field pulses in response to the rf signal;(iii) a switched voltage regulator (4) for regulating the supply voltage by charging a local storage capacitor; and(iv) a controller (13) for causing the switched voltage regulator to charge the local storage capacitor only when a magnetic field pulse is not being transmitted.

Abstract: An rf magnetic field pulse generator for generating an rf magnetic field pulse for use in an NMR investigation. The generator includes two arms connected in parallel between a pair of input terminals, each arm having two serially connected solid-state switches, a transmitter coil connected between output terminals defined between each pair of serially connected solid-state switches respectively, the transmitter coil being adapted to transmit the magnetic field pulse in response to an alternating rf signal at the output terminals, a power source connected to one or both input terminals, and a controller adapted to alternatively operate a respective switch in each arm at a required radio frequency in use whereby the power source is connected with alternating polarity across the transmitter coil and generates an alternating rf signal at the output terminals.

Abstract: An rf coil assembly for use in an NMR investigation, the assembly comprising(1) a transmitter coil (10) adapted to transmit an rf magnetic field suitable for the NMR investigation into a working region and comprising a plurality of serially connected winding elements (1-4); and(2) a receiver coil (9) electrically separate from the transmitter coil and adapted to receive an rf signal from the working region and comprising a plurality of serially connected winding elements (5-9).Winding elements of one coil are interleaved and substantially coaxial with winding elements of the other coil, and at least one of the coils comprises one or more winding elements which are counter-wound with respect to the other winding element(s) in the coil.

Abstract: The present invention relates to an enzyme process for the one-step conversion of cephalosporin C or a derivative thereof into 7-aminocephalosporanic acid or a corresponding derivative thereof.