Abstract: Improved compilers recognize interception declarations in source code, and emit code that replaces invocations of specified artifacts with invocations of specified interceptors instead. Source generators proactively modify program behavior in arbitrary desired ways without introducing hidden security violations and without requiring edits by the program's developers. Interception declarations are visible in source code and development tools. In some cases, different invocations of a particular method at respective locations are intercepted by different replacement methods. Replacement methods have identical signatures, or are otherwise compatible. Some interceptors specify optional parameters. Method calls, field accesses, and property calls may be intercepted. Work to modify program behavior is moved in the program lifecycle from runtime to compile time, thus improving runtime performance and eliminating JIT compilation security risks.

Abstract: The present disclosure relates to methods of treating a malignancy in a subject in need thereof. The method involves administering to the subject a combination therapy comprising: (i) an inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, polymorph, or solvates thereof, and (ii) an inhibitor of an anti-apoptotic Bcl-2 family protein, where the combination therapy is administered in an amount effective to treat the malignancy in the subject. Also disclosed are methods of reducing levels of regulatory T cells in a patient suffering from a malignancy, as well as combination therapeutics comprising an inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1) having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, polymorph, or solvates thereof, and an inhibitor of an anti-apoptotic Bcl-2 family protein.

Abstract: The APPARATUSES, METHODS AND SYSTEMS FOR INSIGHT DISCOVERY AND PRESENTATION FROM STRUCTURED AND UNSTRUCTURED DATA (“IDAP”) provides a platform that, in various embodiments, is configurable to identify, display, and act upon insights derived from large volumes of data. In one embodiment, the IDAP is configurable to determine values and relationships for primal data. Identified relationships may be leveraged to build queries optimized for efficient data access across data volumes. The IDAP may also be configured to identify drivers of global metrics of interest, leverage those drivers to discern the efficacy of media and/or advertising campaigns, and provide recommendations to improve and/or optimize campaign efficacy.

Abstract: The present disclosure relates to methods of treating a malignancy in a subject in need thereof. The method involves administering to the subject a combination therapy comprising: (i) an inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, polymorph, or solvates thereof, and (ii) an inhibitor of an anti-apoptotic Bcl-2 family protein, where the combination therapy is administered in an amount effective to treat the malignancy in the subject. Also disclosed are methods of reducing levels of regulatory T cells in a patient suffering from a malignancy, as well as combination therapeutics comprising an inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein (MALT1) having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, polymorph, or solvates thereof, and an inhibitor of an anti-apoptotic Bcl-2 family protein.

Abstract: The present disclosure is directed to the use of a compound of Formula (III) in the treatment of DLBCL.

Abstract: Disclosed herein are methods and uses of cerdulatinib for treating diseases or conditions, including hematological cancers, and combinations of cerdulatinib for treating such diseases or conditions.

Abstract: Compositions and methods for treating lymphoma, in particular, T-cell lymphoma and follicular lymphoma, in a human patient are provided. The methods entail administering to the patient an effective amount of cerdulatinib.

Abstract: Compositions and methods for treating lymphoma, in particular, T-cell lymphoma and follicular lymphoma, in a human patient are provided. The methods entail administering to the patient an effective amount of cerdulatinib.

Abstract: The APPARATUSES, METHODS AND SYSTEMS FOR COMMON KEY IDENTIFICATION IN DISTRIBUTED DATA ENVIRONMENTS (“KEY IDENTIFIER”) provides a platform that, in various embodiments, is configurable to efficiently identify and display top keys for a keyspace (e.g., social media posts, financial data feeds, and/or the like) distributed across a plurality of worker nodes, such as in response to a client request. For example, the KEY IDENTIFIER may be configured to identify a likely set of candidate keys across the keyspace, and to count and rank those candidates. Once identified, top keys may be employed for a variety of applications or end goals, including but not limited to report generation, natural language insights, data (re-)distributing, and/or the like.

Abstract: The APPARATUSES, METHODS AND SYSTEMS FOR EFFICIENT AD-HOC QUERYING OF DISTRIBUTED DATA (“RTC”) provides a platform that, in various embodiments, is configurable to provide fast ad-hoc querying against large volumes of data. In one embodiment, the RTC is configurable to select a subset of fields from raw data in association with a domain and compact the corresponding data. Such packed records may be distributed to one or more worker nodes, which maintain the records and associated indexes. A master server facilitates query processing across the worker nodes.

Abstract: Disclosed herein are methods and uses of cerdulatinib for treating diseases or conditions, including hematological cancers, and combinations of cerdulatinib for treating such diseases or conditions.

Abstract: A vehicle display system is able to integrate with a license plate holder and replace a license plate to digitally display a name, phrase, logo, or other image. A series of light-emitting diodes may be arrayed across a plate and may be in communication with a digital controller. The controller and the diodes may be powered by the vehicle's electrical systems and may communicate wireless with an external device. In this way, the controller may cause the diodes to display an image which may be energized, deenergized, and customized by the user utilizing the external device. The diodes are encased by a thick lens which draws out the image of the lighted diodes into a three-dimensional hologram, providing depth and visibility to the image.

Abstract: Disclosed herein are methods and uses of cerdulatinib for treating diseases or conditions, including hematological cancers, and combinations of cerdulatinib for treating such diseases or conditions.

Abstract: The APPARATUSES, METHODS AND SYSTEMS FOR INSIGHT DISCOVERY AND PRESENTATION FROM STRUCTURED AND UNSTRUCTURED DATA (“IDAP”) provides a platform that, in various embodiments, is configurable to identify, display, and act upon insights derived from large volumes of data. In one embodiment, the IDAP is configurable to determine values and relationships for primal data. Identified relationships may be leveraged to build queries optimized for efficient data access across data volumes. The IDAP may also be configured to identify drivers of global metrics of interest, leverage those drivers to discern the efficacy of media and/or advertising campaigns, and provide recommendations to improve and/or optimize campaign efficacy.

Abstract: The APPARATUSES, METHODS AND SYSTEMS FOR COMMON KEY IDENTIFICATION IN DISTRIBUTED DATA ENVIRONMENTS (“KEY IDENTIFIER”) provides a platform that, in various embodiments, is configurable to efficiently identify and display top keys for a keyspace (e.g., social media posts, financial data feeds, and/or the like) distributed across a plurality of worker nodes, such as in response to a client request. For example, the KEY IDENTIFIER may be configured to identify a likely set of candidate keys across the keyspace, and to count and rank those candidates. Once identified, top keys may be employed for a variety of applications or end goals, including but not limited to report generation, natural language insights, data (re-)distributing, and/or the like.

Abstract: Compositions and methods for treating lymphoma, in particular, T-cell lymphoma and follicular lymphoma, in a human patient are provided. The methods entail administering to the patient an effective amount of cerdulatinib.

Abstract: The APPARATUSES, METHODS AND SYSTEMS FOR INSIGHT DISCOVERY AND PRESENTATION FROM STRUCTURED AND UNSTRUCTURED DATA (“IDAP”) provides a platform that, in various embodiments, is configurable to identify, display, and act upon insights derived from large volumes of data. In one embodiment, the IDAP is configurable to determine values and relationships for primal data. Identified relationships may be leveraged to build queries optimized for efficient data access across data volumes. The IDAP may also be configured to identify drivers of global metrics of interest, leverage those drivers to discern the efficacy of media and/or advertising campaigns, and provide recommendations to improve and/or optimize campaign efficacy.

Abstract: A maritime beacon includes a controller and multiple communications systems including a bidirectional communications transceiver and a broadcast alert signal generator. The beacon uses the bidirectional communications transceiver to communicate with a remote computer and the broadcast alert signal generator to communicate with recovery vessels in the vicinity. This may allow the local broadcast alert signal generator to be remotely controlled to better facilitate recovery of the beacon and associated assets.

Abstract: Automated test equipment (ATE) capable of performing a test of semiconductor devices is presented. The ATE comprises a computer system comprising a system controller communicatively coupled to a tester processor. The system controller is operable to transmit instructions to the processor and the processor is operable to generate commands and data from the instructions for coordinating testing of a plurality of devices under test (DUTs). The ATE further comprises a plurality of FPGA components communicatively coupled to the processor via a bus. Each of the FPGA components comprises at least one hardware accelerator circuit operable to internally generate commands and data transparently from the processor for testing one of the DUTs. Additionally, the tester processor is configured to operate in one of several functional modes, wherein the functional modes are configured to allocate functionality for generating commands and data between the processor and the FPGA components.

Abstract: Disclosed herein are methods and uses of cerdulatinib for treating diseases or conditions, including hematological cancers, and combinations of cerdulatinib for treating such diseases or conditions.