Patents by Inventor Andrew Stelzer

Andrew Stelzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput ensemble-based docking and elucidation of 3-dimensional structural conformations of flexible biomolecular targets
    Patent number: 8498823
    Abstract: Methods for generating putative ligand structures capable of altering the activity of a target effector molecule comprise: constructing an elongated monomer of the target effector molecule; constructing a three dimensional model of the target effector molecule under the influence of elongation using empirical three dimensional data, the model including a conformation revealing the binding portion of the target effector molecule to a putative ligand structure; generating a plurality of computational models of the target effector molecule; filtering the plurality of computational models against the three dimensional model created experimentally using a reiterative simulation analysis algorithm operable to identify and select a plurality of computational models having a root-mean square deviation below a predetermined threshold when compared to the three dimensional model of the target effector molecule; screening a plurality of ligands to rank the binding strength of each ligand with the plurality of computatio
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: July 30, 2013
    Assignee: The Regents of The University of Michigan
    Inventors: Hashim M. Al-Hashimi, Andrew Stelzer, Ioan Andricioaei, Aaron Frank
  • HIGH THROUGHPUT ENSEMBLE-BASED DOCKING AND ELUCIDATION OF THREE-DIMENSIONAL STRUCTURAL CONFIRMATIONS OF FLEXIBLE BIOMOLECULAR TARGETS
    Publication number: 20110172981
    Abstract: Methods for generating putative ligand structures capable of altering the activity of a target effector molecule comprise: constructing an elongated monomer of the target effector molecule; constructing a three dimensional model of the target effector molecule under the influence of elongation using empirical three dimensional data, the model including a conformation revealing the binding portion of the target effector molecule to a putative ligand structure; generating a plurality of computational models of the target effector molecule; filtering the plurality of computational models against the three dimensional model created experimentally using a reiterative simulation analysis algorithm operable to identify and select a plurality of computational models having a root-mean square deviation below a predetermined threshold when compared to the three dimensional model of the target effector molecule; screening a plurality of ligands to rank the binding strength of each ligand with the plurality of computatio
    Type: Application
    Filed: September 25, 2009
    Publication date: July 14, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Hashim M. Al-Hashimi, Andrew Stelzer, Ioan Andricioaei, Aaron Frank