Abstract: Methods are described for the isolation of nucleic acid ligands to integrins using the SELEX process. SELEX is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the present invention are useful as therapeutic and diagnostic agents.

Abstract: A method of selectively establishing any one connection of several different types, between a client program in a first computer and a server program in a second computer, includes the following steps. Initially, a control program is provided in the first computer which receives a command with parameters, from the client program, that specify the one type of connection which is to be established. In response, the control program automatically constructs a particular pipename which includes the parameters in a format that differs for each different type of connection. Thereafter, the control program tranmits the pipename which it constructed to a communications program in the second computer. Subsequently, the control program receives a result from the communications program which indicates whether or not the communications program used the pipename to successfully establish the one type of connection to the server program. Then, the control program notifies the client program of the result.

Abstract: A flowmeter for a medium includes two transducers displaced from each other in the direction of flow of the medium. The flowmeter contains an emitting device which emits acoustic signals in both directions through the medium using the transducer. The flowmeter also contains a processing device for determining information via the flow of the medium by monitoring the travel times of the acoustic signals received by the transducers. A part of the space between the transducers defines a flow path which includes a flow structure with at least one medium flow passage extending axially in the direction of the flow of the medium. The medium flow passage has damping devices which are located so that at least one asymmetrical noise propagation mode is damped. The damping device has a damping structure which extends substantially across the whole length of the media flow passage.

Abstract: Methods are described for the isolation of nucleic acid ligands to integrins using the SELEX process. SELEX is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the present invention are useful as therapeutic and diagnostic agents.

Abstract: A flexible and extensible virtual printer architecture is provided. According to one aspect of the present invention, a mechanism is provided for driving multiple heterogeneous presentation devices. A presentation job is received on behalf of a presentation device, the presentation job includes a data stream which contains source data in the form of text, image, graphics, and/or other embedded objects. The source data is then reduced to an intermediate format. Based upon the intermediate format and control information associated with the data stream, device-specific data and device-specific control information are generated for the presentation device. Finally, the presentation device is driven by providing the device-specific data and device-specific control information to the presentation device.

Abstract: Heterogeneous data is transferred from a first computer to a second computer such that a) the data includes multiple data types in respective formats that are native to the first computer but are foreign to the second computer, and b) meaningful interrelationships among the multiple data types are conveyed.

Abstract: A flexible and extensible virtual printer architecture is provided. According to one aspect of the present invention, a mechanism is provided for driving multiple heterogeneous presentation devices. A presentation job is received on behalf of a presentation device, the presentation job includes a data stream which contains source data in the form of text, image, graphics, and/or other embedded objects. The source data is then reduced to an intermediate format. Based upon the intermediate format and control information associated with the data stream, device-specific data and device-specific control information are generated for the presentation device. Finally, the presentation device is driven by providing the device-specific data and device-specific control information to the presentation device.

Abstract: A puppet (10) or other character representation includes an inner tube (11), an outer tube (12) and an extra tube (13) located within the inner tube (11). The upper ends of the inner and outer tubes (11 and 12) are connected by a sleeve (23) of simulation hair. A moulding (16) is secured to the outer tube (12) and has the appropriate facial characteristics including an opening (19) corresponding to the mouth of the character. The extra tube (13) has an upper edge which is connected to the part of the moulding (16) which provides the lower jaw of the character.

Abstract: This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to blood vessels are described.

Abstract: A new class of nucleic acid compounds, referred to as nucleic acid ligands, have been shown to exist that have a specific binding affinity for three dimensional molecular targets, including cell surface macromolecules. The nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched and the high affinity nucleic acids are amplified for further partitioning. The high affinity nucleic acid ligands are useful in capturing target cells.

Abstract: A bulkhead assembly, for use with a cargo container (10) within which is provided a liner (15) for the bulk transport of flowable materials, has a plurality of elongate members (20) which extend upwardly from the floor (11) of the container, but with a central region (25) adjacent the container floor (11) free from obstruction. A flexible sheet (26) is folded to form two overlying layers (27, 28) joined together to define pockets in which are positioned two pairs of rigid plates (29, 30), the inner pair of plates (29) being spaced apart. In use, the sheet (26) is arranged adjacent the container floor, so as to extend over the central region (25), and also to provide corner fillets for the container, the lower region of the liner when in use being supported by the sheet (26) and the plates (29, 30).

Abstract: Ion implantation equipment is modified so as to provide filament reflectors to a filament inside of an arc chamber, and to remove the electrical insulators for the filament outside of the arc chamber and providing a means of shielding, thereby reducing the formation of a conductive layer on said insulators and greatly extending the lifetime and reducing downtime of the equipment. The efficiency of the equipment is further enhanced by means of an interchangeable liner for the arc chamber that increases the wall temperature of the arc chamber and thus the electron temperature. The use of tungsten parts inside the arc chamber, obtained either by making the arc chamber itself or portions thereof of tungsten, particularly the front plate having the exit aperture for the ion beam, or by inserting a removable tungsten liner therein, decreases contamination of the ion beam. Serviceability of the arc chamber is improved by means of a unitary clamp that separately grips both the filament and filament reflectors.

Abstract: The present invention relates to substituted .omega.-?phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl! ?alkyl, alkenyl or alkynyl!amine carboxamides, sulfonamides and phosphonylamides which are useful as antiarrhythmic agents.

Abstract: This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.

Abstract: This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.

Abstract: A cable locking and sealing device has an elongate body of elastomeric material formed with at least one through-passage for receiving a cable and at least one longitudinal slit extending down at least a portion of its length. The interior of the through passage is formed with a series of annular ribs which each taper in depth towards a point adjacent the longitudinal slit. When the device is pulled into an entry port, its elongate body becomes radially compressed thereby holding the cable firmly in place: however, the sealing effect of the ribs against the cable is not compromised by any relative longitudinal displacement of the portions of the body either side of the slit.

Abstract: An enclosure assembly for optical fibre splices or other optical fibre components comprises a plurality of trays disposed in a stack with the trays inclined at a common angle to a longitudinal axis of the stack. Each tray is of generally elliptical shape in plan and is pivotally mounted, adjacent one end of its major axis, to an upright support.

Abstract: This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.

Abstract: This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to peripheral blood mononuclear cells (PBMC), fibrin clots, and carotid arteries are described.

Abstract: This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.