Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two step chromatography process starting with an anion exchange chromatography step followed by a polishing chromatography step selected from mixed mode chromatography or cation exchange chromatography.

Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two step chromatography process starting with an anion exchange chromatography step followed by a polishing chromatography step selected from mixed mode chromatography or cation exchange chromatography.

Abstract: Navigation assistance systems and methods for use with a surgical instrument to assist in navigation of a surgical instrument during an operation. The system may include sensors that may observe the patient to generate positioning data regarding the relative position of the surgical instrument and the patient. The system may retrieve imaging data regarding the patient and correlate the imaging data to the positioning data. In turn, the position of the surgical instrument relative to the imaging data may be provided and used to generate navigation date (e.g., position, orientation, trajectory, or the like) regarding the surgical instrument.

Abstract: The present invention provides a nanoparticle capable of binding specifically to a target protein in a solution and precipitating with the target protein out of the solution upon addition of the target protein to the solution. The precipitation may be reversed release the target protein from the nanoparticle, which may be reused for precipitating the target protein. Also provided are a method for purifying a target protein by affinity precipitation using the nanoparticle without chromatography and a method for preparing the nanoparticle.

Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two step chromatography process starting with an anion exchange chromatography step followed by a polishing chromatography step selected from mixed mode chromatography or cation exchange chromatography.

Abstract: The present invention relates to a matte coating composition comprising an aqueous dispersion of a) polymer particles having an average particle size in the range of from 80 nm to 500 nm; b) polymeric organic crosslinked microspheres having a particle size in the range of from 1 ?m to 20 ?m; c) polyethylene wax particles having a particle size in the range of from 0.3 ?m to 30 ?m; and d) a rheology modifier. The composition of the present invention gives matte finish coatings with excellent burnish resistance.

Abstract: Navigation assistance systems and methods for use with a surgical instrument to assist in navigation of a surgical instrument during an operation. The system may include sensors that may observe the patient to generate positioning data regarding the relative position of the surgical instrument and the patient. The system may retrieve imaging data regarding the patient and correlate the imaging data to the positioning data. In turn, the position of the surgical instrument relative to the imaging data may be provided and used to generate navigation date (e.g., position, orientation, trajectory, or the like) regarding the surgical instrument.

Abstract: Navigation assistance systems and methods for use with a surgical instrument to assist in navigation of a surgical instrument during an operation. The system may include sensors that may observe the patient to generate positioning data regarding the relative position of the surgical instrument and the patient. The system may retrieve imaging data regarding the patient and correlate the imaging data to the positioning data. In turn, the position of the surgical instrument relative to the imaging data may be provided and used to generate navigation date (e.g., position, orientation, trajectory, or the like) regarding the surgical instrument.

Abstract: The present invention provides a composition comprising 1) an aqueous dispersion of polymer particles having a core-shell morphology wherein the core protuberates from the shell; wherein the core comprises from 5 to 90 weight percent structural units of a fluoroalkylated monomer, and 2) less than 0.09 weight percent structural units of a phosphorus acid monomer; and wherein the shell comprises from 0.1 to 5 weight percent of itaconic acid or a phosphorus acid monomer, based on the weight of the shell. The present invention addresses a need in the art by providing a way of selectively concentrating fluoroalkyl functionality into polymer particles with acorn morphology, thereby providing an improvement in dirt pick-up resistance of the subsequent coating.

Abstract: Navigation assistance systems and methods for use with a surgical instrument to assist in navigation of a surgical instrument during an operation. The system may include sensors that may observe the patient to generate positioning data regarding the relative position of the surgical instrument and the patient. The system may retrieve imaging data regarding the patient and correlate the imaging data to the positioning data. In turn, the position of the surgical instrument relative to the imaging data may be provided and used to generate navigation date (e.g., position, orientation, trajectory, or the like) regarding the surgical instrument.

Abstract: The present invention relates to a matte coating composition comprising an aqueous dispersion of a) polymer particles having an average particle size in the range of from 80 nm to 500 nm; b) polymeric organic crosslinked microspheres having a particle size in the range of from 1 ?m to 20 ?m; c) polyethylene wax particles having a particle size in the range of from 0.3 ?m to 30 ?m; and d) a rheology modifier. The composition of the present invention gives matte finish coatings with excellent burnish resistance.

Abstract: The present invention relates to a composition comprising 1) an aqueous dispersion of polymer particles having a core-shell morphology wherein the core protuberates from the shell and comprises less than 0.09 structural units of a phosphorus acid monomer, based on the weight of the core; and 2) pigment particles with a refractive index in the range of from 2.0 and 3.0, wherein the pigment volume concentration of the pigment particles is at least 11. The composition of the present invention is useful for improving block resistance in coatings applications.

Abstract: The present invention provides a nanoparticle capable of binding specifically to a target protein in a solution and precipitating with the target protein out of the solution upon addition of the target protein to the solution. The precipitation may be reversed release the target protein from the nanoparticle, which may be reused for precipitating the target protein. Also provided are a method for purifying a target protein by affinity precipitation using the nanoparticle without chromatography and a method for preparing the nanoparticle.

Abstract: The present invention provides a composition comprising 1) an aqueous dispersion of polymer particles having a core-shell morphology wherein the core protuberates from the shell; wherein the core comprises from 5 to 90 weight percent structural units of a fluoroalkylated monomer, and 2) less than 0.09 weight percent structural units of a phosphorus acid monomer; and wherein the shell comprises from 0.1 to 5 weight percent of itaconic acid or a phosphorus acid monomer, based on the weight of the shell. The present invention addresses a need in the art by providing a way of selectively concentrating fluoroalkyl functionality into polymer particles with acorn morphology, thereby providing an improvement in dirt pick-up resistance of the subsequent coating.

Abstract: The present invention relates to a composition comprising 1) an aqueous dispersion of polymer particles having a core-shell morphology wherein the core protuberates from the shell and comprises less than 0.09 structural units of a phosphorus acid monomer, based on the weight of the core; and 2) pigment particles with a refractive index in the range of from 2.0 and 3.0, wherein the pigment volume concentration of the pigment particles is at least 11. The composition of the present invention is useful for improving block resistance in coatings applications.

Abstract: The present invention provides two-component polyurethane compositions that are substantially free of VOCs and comprising, as one component, polyisocyanate compositions and, as a second component, a polyol which is chosen from a cycloaliphatic diol or polyol having a molecular weight of from 100 to 500 and containing one or more 4 to 7 member aliphatic ring and an oligomeric diol or polyol comprising the condensation reaction product of from 30 wt. % to 78 wt. %, based on the total weight of reactants used to make the oligomer, and an acrylic or vinyl emulsion polymer.

Abstract: The present invention relates to a composition comprising a stable aqueous dispersion of polyurethane particles and pigment particles partially or fully encapsulated with a soft polymer. The composition of the present invention delivers relatively high gloss as well as gloss stability in coatings formulations.

Abstract: The instant invention provides a crosslinkable aqueous composition, method of producing the same, crosslinked compositions, and method of producing the same. The crosslinkable composition comprising: an aqueous dispersion comprising; (a) water; (b) a polycarbamate comprising at least an average of 2.0 carbamate functional groups; (c) a polyaldehyde comprising at least two aldehyde groups; (d) an acid catalyst; and (e) optionally one or more surfactants; wherein said aqueous dispersion has a pH in the range of less than 7; and wherein said composition is capable of being crosslinked at a temperature in range of less than 80° C. upon substantial removal of water.

Abstract: The present invention relates to a process for imbibing a step-growth polymer into thermoplastic latex particles and a composition made by such a process. The composition is useful, for example, as a coating, an adhesive, a sealant, a primer, a caulk, a stain, or a filler for a variety of substrates.

Abstract: The instant invention provides a crosslinkable aqueous composition, method of producing the same, crosslinked compositions, and method of producing the same. The crosslinkable composition comprising: an aqueous dispersion comprising; (a) water; (b) a polycarbamate comprising at least an average of 2.0 carbamate functional groups; (c) a polyaldehyde comprising at least two aldehyde groups; (d) an acid catalyst; and (e) optionally one or more surfactants; wherein said aqueous dispersion has a pH in the range of less than 7; and wherein said composition is capable of being crosslinked at a temperature in range of less than 80° C. upon substantial removal of water.