Abstract: Absorbent structures and methods of manufacture are disclosed. In one embodiment, a method of manufacturing may comprise, directing a stream of particles toward a layer, spraying the stream with a first adhesive, the first adhesive contacting the stream at a first contact point, spraying the stream with a second adhesive, the second adhesive contacting the stream at a second contact point, the first contact point being different from the second contact point, depositing the intermixed particles, first adhesive, and second adhesive onto the layer, and covering the mixture of the particles, the first adhesive, and the second adhesive with a second layer.

Abstract: Absorbent structures and methods of manufacture are disclosed. In one embodiment, an absorbent structure may comprise a first layer, a second layer, and a mixture of particles and adhesive disposed therebetween, the superabsorbent particles being disposed at greater than 400 gsm and less than 600 gsm, and the adhesive being disposed at greater than 4% and less than 5%, by weight, of the weight of the superabsorbent particles. The adhesive may form a three-dimensional mesh network comprising network adhesive filaments with the superabsorbent particles immobilized within the mesh network, and the network adhesive filaments extending substantially throughout a three-dimensional space defined by the network adhesive filaments and the superabsorbent particles, and wherein the absorbent structure has a SAM Capture Value greater than or equal to 98, according to the SAM Capture Test Method.

Abstract: Absorbent structures and methods of manufacture are disclosed. In one embodiment, a method of manufacturing an absorbent structure may comprise directing a stream of particles toward a material layer, spraying the stream with a first adhesive, the first adhesive contacting the stream at a first contact point, spraying the stream with a second adhesive, the second adhesive contacting the stream at a second contact point, depositing the particles, first adhesive, and second adhesive onto the material layer, and separating the mixture of the particles, adhesive, and the material layer into individual absorbent structures, each absorbent structure produced having particles disposed in an amount equal to 500 gsm and adhesive disposed in an amount equal to 7% by weight, of the weight of the superabsorbent particles, and having Wet Pad Integrity values greater than or equal to 20, according to the Wet Pad Integrity Test Method.

Abstract: Absorbent structures and methods of manufacture are disclosed. In one embodiment, an absorbent structure may comprise a first layer, a second layer, and a mixture of particles and adhesive between the first layer and the second layer, wherein the particles are disposed at greater than 400 gsm and less than 600 gsm, wherein the adhesive is disposed at greater than 4% and less than 6%, by weight, of the weight of the particles, wherein the adhesive forms a three-dimensional mesh network comprising network adhesive filaments with the particles immobilized within the mesh network, and the network adhesive filaments extending substantially throughout a three-dimensional space defined by the network adhesive filaments and the particles, the structure having a Gray Level % Coefficient of Variability value (GL % COV) of less than or equal to 34.5, according to the Pad Uniformity Test Method.

Abstract: Absorbent structures and methods of manufacture are disclosed. In one embodiment, an absorbent structure may comprise first and second substrate material layers and a mixture of superabsorbent particles and adhesive disposed between the first and second substrate material layers. The superabsorbent particles may be disposed in an amount greater than 400 gsm, and the adhesive may be disposed in an amount less than 5%, by weight, of the weight of the superabsorbent particles, and the adhesive forms a three-dimensional mesh network comprising network adhesive filaments with the superabsorbent particles immobilized within the mesh network, and the network adhesive filaments extending substantially throughout a three-dimensional space defined by the network adhesive filaments and the superabsorbent particles.

Abstract: A microneedle array assembly includes a microneedle array that has a plurality of microneedles. A distribution manifold includes a fluid supply channel that is coupled in flow communication to a plurality of resistance channels. Each of the resistance channels are coupled in flow communication to a respective one of the microneedles of the microneedle array. The resistance channels have a resistance value to a fluid flow through each resistance channel that is in the range between about 5 times greater to about 100 times greater than a resistance to the fluid flow through the supply channel.

Abstract: A process for forming multi-layer fibrous web with good absorbent capacity and absorbent rate is disclosed. The multi-layer fibrous web can be used as absorbent articles, including wiping products, such as industrial wipers, food service wipers, and the like. The multi-layer fibrous web includes a first layer and a second layer, as well as a crossover zone, that has a capillary pressure between the capillary pressure of the first layer and the capillary pressure of the second layer.

Abstract: A fluid delivery apparatus includes a collet assembly having an upper and lower wall attached at a central portion of the collet. The central portion defines an inner step, and the lower wall includes circumferentially-spaced flexible tabs. The fluid delivery apparatus also includes a fluid distribution assembly coupled to the collet assembly. The fluid distribution assembly is positionable relative to the collet between a pre-use configuration and a pre-activated configuration. The fluid distribution assembly has a plenum that includes a sleeve component having an exterior ledge extending thereabout. A lower wall portion of the sleeve component includes protrusions corresponding to the flexible tabs of the collet. In the pre-use configuration the exterior ledge of the sleeve component is engaged with the inner step of the collet assembly, and each flexible tab engages a respective protrusion to provide a snap-fit between the fluid distribution assembly and the collet assembly.

Abstract: A one-ply absorbent article comprising a nonwoven first layer; a non-woven third layer; a nonwoven second layer between the first layer and the third layer; and wherein the one-ply absorbent article has a first absorbency measure at a first delamination state and a second absorbency measure at a second delamination state, wherein the first absorbency measure is less than the second absorbency measure and the first delamination state is less than the second delamination state.

Abstract: A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient. A flow rate of the medicament from the fluid delivery apparatus is adjusted such that the medicament is delivered to the patient for at least a predetermined time period. The fluid delivery apparatus includes a controller assembly having a body component defining an axis and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component and a second position in which the plunger component is furthest from the body component. A bias assembly is positioned between the body component and the plunger component. The bias assembly is configured to apply a two stage force profile to the plunger component.

Abstract: A transdermal drug delivery apparatus includes a housing for being fastened to a user, a microneedle assembly for being engaged against the skin of the user, a first force provider for providing a first force for forcing the microneedle assembly outwardly from the housing and against the skin, a reservoir movably carried by the housing for containing the fluid and for being in fluid communication with the microneedle assembly, and a second force provider for providing a second force for causing at least some of the fluid to flow from the reservoir to the microneedle assembly after the reservoir has moved into fluid communication with the microneedle assembly.

Abstract: A microneedle array assembly includes a microneedle array that has a plurality of microneedles. A distribution manifold includes a fluid supply channel that is coupled in flow communication to a plurality of resistance channels. Each of the resistance channels are coupled in flow communication to a respective one of the microneedles of the microneedle array. The resistance channels have a resistance value to a fluid flow through each resistance channel that is in the range between about 5 times greater to about 100 times greater than a resistance to the fluid flow through the supply channel.

Abstract: A controller assembly of a fluid delivery apparatus includes a body component and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component, and a second position in which the plunger component is furthest from the body component. A bias assembly positioned between the body component and the plunger component applies a two stage force profile to the plunger component. The bias assembly includes a first and a second biasing member. In the first position, the first and second biasing members apply first and second forces profiles, respectively, to the plunger component. In the second position, the first biasing member is prevented from applying the first force profile to the plunger component, and the second biasing member applies the second force profile to the plunger component.

Abstract: A microneedle array assembly includes a microneedle array that has a plurality of microneedles. A distribution manifold includes a fluid supply channel that is coupled in flow communication to a plurality of resistance channels. Each of the resistance channels are coupled in flow communication to a respective one of the microneedles of the microneedle array. The resistance channels have a resistance value to a fluid flow through each resistance channel that is in the range between about 5 times greater to about 100 times greater than a resistance to the fluid flow through the supply channel.

Abstract: A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient. A flow rate of the medicament from the fluid delivery apparatus is adjusted such that the medicament is delivered to the patient for at least a predetermined time period. The fluid delivery apparatus includes a controller assembly having a body component defining an axis and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component and a second position in which the plunger component is furthest from the body component. A bias assembly is positioned between the body component and the plunger component. The bias assembly is configured to apply a two stage force profile to the plunger component.

Abstract: A transdermal drug delivery apparatus includes a receptacle having a housing and a microneedle assembly mounted to the housing. The apparatus includes a reservoir for being mounted to the receptacle. The reservoir has an interior for containing fluid for being supplied to the microneedle assembly. The apparatus is adapted so that, when the apparatus is assembled, the reservoir is configured to move relative to the microneedle assembly along a path from an outer position to an inner position. The reservoir is closer to the microneedle assembly in the inner position than in the outer position. In the outer position, the reservoir is out of fluid communication with the microneedle assembly, and in the inner position, the reservoir is in fluid communication with the microneedle assembly. The apparatus also includes a plurality of connector parts spaced apart from one another along the path.

Abstract: A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across a broad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array.

Abstract: A gas extraction device for a fluid delivery apparatus includes a first layer and a vent membrane coupled to the first layer. The vent membrane enables a gas to pass through the vent membrane and prevents a fluid from passing through the vent membrane. The gas extraction device also includes a second layer coupled to the vent membrane opposite the first layer. The second layer has a first channel formed therethrough. In addition, the gas extraction device includes an impermeable membrane coupled to the second layer opposite the vent membrane. The first channel is configured to receive a fluid having a gas dispersed therein. The fluid is pressurized to move the fluid through the first channel against the vent membrane and to move the gas through the vent membrane.

Abstract: An attachment band for a fluid delivery apparatus includes an annular body having a wall defining a hollow inner space, an adjacent pair of attachment apertures extending through the wall, and an indicator aperture extending through the wall opposite the pair of attachment apertures. The indicator aperture includes an indicator portion that is configured to present an indication to a user of the fluid delivery apparatus of a tightness of the attachment band. A first strap extends radially outward from the annular body of the attachment band and is substantially aligned with the attachment apertures. A second strap extends radially outward from the annular body and is substantially aligned with the indicator aperture.

Abstract: A method for administering a medicament to a patient includes placing a fluid delivery apparatus with the medicament in contact with a portion of the skin of said patient. A flow rate of the medicament from the fluid delivery apparatus is adjusted such that the medicament is delivered to the patient for a predetermined time period. The fluid delivery apparatus includes a controller assembly having a body component defining an axis and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component and a second position in which the plunger component is furthest from the body component. A bias assembly is positioned between the body component and the plunger component. The bias assembly is configured to apply a two stage force profile to the plunger component.