Patents by Inventor Andrew T. Bruce
Andrew T. Bruce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240277447Abstract: A biopsy site marker includes a carrier and a marker element. The marker element is disposed within the carrier. The carrier including a first marker material and a second marker material. The first marker material and the second marker material are each configured to expand in the presence of moisture. The first marker material is configured to expand at a rapid rate relative to the second marker material in the presence of moisture.Type: ApplicationFiled: May 2, 2024Publication date: August 22, 2024Inventors: Elijah Kreider, Peter Shadix, Emmanuel V. Tanghal, Jordan Rebellino, Andrew Small, Ramon Alberto Ramos, Taylor Vohland, Jack A. Randall, David C. McBreen, LeRonda Perry, Edward A. Rhad, Jessica P. Leimbach, Sarah Payne, Anne E. Storer, Andrew T. Robinson, John Kevin Bruce, Rachel Yoon Choung
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Publication number: 20240108657Abstract: The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.Type: ApplicationFiled: October 10, 2023Publication date: April 4, 2024Inventors: Sharon C. Presnell, Andrew T. Bruce, Shay M. Wallace, Sumana Choudhury, Russell W. Kelley, Manuel J. Jayo, Jessica J. Reinsch, Patricia D. Tatsumi, Timothy A. Bertram, Eric S. Werdin, Oluwatoyin A. Knight, H. Scott Rapoport, Roger M. Ilagan
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Publication number: 20210238600Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.Type: ApplicationFiled: February 9, 2021Publication date: August 5, 2021Inventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric S. Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Jr., Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Patent number: 11066666Abstract: The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.Type: GrantFiled: March 19, 2018Date of Patent: July 20, 2021Assignee: inRegenInventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Publication number: 20190117695Abstract: The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.Type: ApplicationFiled: October 15, 2018Publication date: April 25, 2019Inventors: Sharon C. Presnell, Andrew T. Bruce, Shay M. Wallace, Sumana Choudhury, Russell W. Kelley, Manuel J. Jayo, Jessica J. Reinsch, Patricia D. Tatsumi, Timothy Bertram, Eric S. Werdin, Oluwatoyin A. Knight, H. Scott Rapoport, Roger M. Ilagan
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Publication number: 20180282726Abstract: The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.Type: ApplicationFiled: March 19, 2018Publication date: October 4, 2018Inventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darrell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Patent number: 10077442Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.Type: GrantFiled: May 12, 2011Date of Patent: September 18, 2018Assignee: inRegenInventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Patent number: 10030242Abstract: The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.Type: GrantFiled: May 12, 2011Date of Patent: July 24, 2018Assignee: InRegenInventors: Timothy A. Bertram, Roger M. Ilagan, Russell W. Kelley, Sharon C. Presnell, Sumana Choudhury, Andrew T. Bruce, Christopher W. Genheimer, Bryan R. Cox, Kelly I. Guthrie, Joydeep Basu, Shay M. Wallace, Eric Werdin, Oluwatoyin A. Knight, Namrata D. Sangha, John W. Ludlow, Craig R. Halberstadt, Richard Payne, Neil F. Robins, Darell McCoy, Deepak Jain, Manuel J. Jayo, Elias A. Rivera, Thomas Spencer, Benjamin Watts
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Publication number: 20170205398Abstract: The present invention concerns bioactive renal cell populations, in particular a B2 cell population comprising an enriched population of tubular cells and wherein the renal cell population is depleed of a B1 cell population, renal cell constructs, and methods of screening test agents using the bioactive renal cell populations.Type: ApplicationFiled: September 16, 2016Publication date: July 20, 2017Inventors: ANDREW T. BRUCE, RUSSELL W. KELLEY, TIMOTHY A. BERTRAM, SUMANA CHOUDHURY
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Publication number: 20170096641Abstract: Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor.Type: ApplicationFiled: October 12, 2016Publication date: April 6, 2017Applicants: Vesta Therapeutics Inc., University of North Carolina at Chapel HillInventors: Lola M. REID, Nicholas MOSS, Mark E. FURTH, John W. LUDLOW, Andrew T. BRUCE
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Publication number: 20140308695Abstract: The present invention concerns bioactive renal cell populations, in particular a B2 cell population comprising an enriched population of tubular cells and wherein the renal cell population is depleted of a B1 cell population, renal cell constructs, and methods of screening test agents using the bioactive renal cell populations.Type: ApplicationFiled: November 5, 2012Publication date: October 16, 2014Inventors: Andrew T. Bruce, Russell W. Kelley, Timothy A. Bertram, Sumana Choudhury
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Publication number: 20140302601Abstract: Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor.Type: ApplicationFiled: April 3, 2014Publication date: October 9, 2014Applicants: University of North Carolina at Chapel Hill, Vesta Therapeutics Inc.Inventors: Lola M. REID, Nicholas MOSS, Mark E. FURTH, John W. LUDLOW, Andrew T. BRUCE
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Patent number: 8691523Abstract: Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor.Type: GrantFiled: December 12, 2006Date of Patent: April 8, 2014Assignees: Vesta Therapeautics, Inc., University of North Carolina at Chapel HillInventors: Lola M. Reid, Nicholas Moss, Mark E. Furth, John W. Ludlow, Andrew T. Bruce
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Publication number: 20110224800Abstract: The present invention relates to the regeneration, reconstruction, augmentation or replacement of organs or tissue structures using scaffolds and cells derived from peritoneal tissue.Type: ApplicationFiled: March 8, 2011Publication date: September 15, 2011Inventors: John W. Ludlow, Kelly I. Guthrie, Andrew T. Bruce, Kenny Johnson
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Publication number: 20100112689Abstract: The present invention is directed toward a method for obtaining from whole liver or a resection thereof a population of cells comprising viable, functional liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells, compositions thereof, and uses therefore. Compositions include a composition of liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells and a pharmaceutical composition thereof. Uses include treatment of liver diseases, regeneration of liver, toxicity testing, and liver assist devices.Type: ApplicationFiled: May 13, 2009Publication date: May 6, 2010Inventors: John W. Ludlow, Mark E. Furth, Andrew T. Bruce, Lola M. Reid, Robert L. Susick, JR.
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Patent number: 7413897Abstract: Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor.Type: GrantFiled: March 14, 2003Date of Patent: August 19, 2008Assignees: University of North Carolina at Chapel Hill, Vesta Therapeutics, Inc.Inventors: Lola M. Reid, Nicholas Moss, Mark Furth, John W. Ludlow, Andrew T. Bruce
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Publication number: 20040110289Abstract: The present invention is directed toward a method for obtaining from whole liver or a resection thereof a population of cells comprising viable, functional liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells, compositions thereof, and uses therefore. Compositions include a composition of liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells and a pharmaceutical composition thereof. Uses include treatment of liver diseases, regeneration of liver, toxicity testing, and liver assist devices.Type: ApplicationFiled: July 17, 2003Publication date: June 10, 2004Inventors: John W. Ludlow, Mark E. Furth, Andrew T. Bruce, Lola M. Reid, Robert L. Susick
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Publication number: 20040018621Abstract: Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor.Type: ApplicationFiled: March 14, 2003Publication date: January 29, 2004Inventors: Lola Reid, Nick Moss, Mark E. Furth, John W. Ludlow, Andrew T. Bruce