Patents by Inventor Andrew T. Chiu

Andrew T. Chiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies to tissue plasminogen activator (T-PA) which prolong its functional half-life
    Patent number: 5225540
    Abstract: High-affinity murine monoclonal antibodies to t-PA were prepared which prolong the in vivo functional half-life of t-PA without decreasing its plasminogen-activator activity.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: July 6, 1993
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Thomas M. Reilly, Andrew T. Chiu, Robert M. Knabb
  • Treatment of central nervous disorders with imidazole compounds
    Patent number: 5179113
    Abstract: Imidazole compounds such as 5-[4-(3-(N-isopropylamino)hydroxypropoxy)indole-2-carboxamidomethyl]-2-n-b utyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloroimidazole and their pharmaceutically suitable salts are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: January 12, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, Victor J. De Noble, John J. V. Duncia, Pancras C. B. Wong
  • Specific inhibition of angiotensin-II binding to angiotensin-II receptor subtype-2
    Patent number: 5173494
    Abstract: 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives such as 1-(4-amino-3-methylphenyl) methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-car boxylic acid are useful for treatment of CNS disorders, such as cognitive and learning disorders, mediated by angiotensin-II.
    Type: Grant
    Filed: November 21, 1991
    Date of Patent: December 22, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, John J. Duncia
  • Treatment of central nervous system disorders with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists
    Patent number: 5155126
    Abstract: Substituted pyrazole, pyrrole and triazole angiotensin-II-1 receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin-II.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: October 13, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, Victor De Noble, John J. Duncia, Pancras C. Wong
  • Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists
    Patent number: 5140037
    Abstract: Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxy methyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imi dazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.
    Type: Grant
    Filed: March 20, 1990
    Date of Patent: August 18, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, Victor J. DeNoble, John J. V. Duncia, Pancras C. B. Wong
  • Treatment of central nervous system disorders with benzimidazole angiotensin-II receptor antagonists
    Patent number: 5137906
    Abstract: Substituted benzimidazoles such as 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-6-chlorobenzimidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.
    Type: Grant
    Filed: March 20, 1990
    Date of Patent: August 11, 1992
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Andrew T. Chiu, Victor J. De Noble, John J. V. Duncia, Pancras C. B. Wong
  • Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs
    Patent number: 5091390
    Abstract: Provided are 4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-pyridine derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat disorders of mammals mediated by AII type-2 receptors in the central nervous system.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: February 25, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, Andrew T. Chiu, John J. V. Duncia, Petrus B. M. W. M. Timmermans, Ruth R. Wexler