Patents by Inventor Andrew T. PARSONS

Andrew T. PARSONS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250179068
    Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2?,2?-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
    Type: Application
    Filed: December 19, 2024
    Publication date: June 5, 2025
    Applicant: AMGEN INC.
    Inventors: Andrew T. PARSONS, Matthew G. BEAVER
  • Publication number: 20250129072
    Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base.
    Type: Application
    Filed: December 19, 2024
    Publication date: April 24, 2025
    Applicant: AMGEN INC.
    Inventors: Michal ACHMATOWICZ, John T. COLYER, Michael T. CORBETT, Daniel J. GRIFFIN, Andrew T. PARSONS, Joanna ROBINSON, Kyle QUASDORF
  • Publication number: 20250122197
    Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.
    Type: Application
    Filed: December 19, 2024
    Publication date: April 17, 2025
    Applicant: AMGEN INC.
    Inventors: Matthew G. BEAVER, Michael T. CORBETT, Yuanqing FANG, David D. FORD, Andrew T. PARSONS, Gabrielle ST-PIERRE, Reem TELMESANI
  • Publication number: 20240025896
    Abstract: Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes [Insert Structure] (Compound A).
    Type: Application
    Filed: November 19, 2021
    Publication date: January 25, 2024
    Applicant: AMGEN INC.
    Inventors: Michal ACHMATOWICZ, John T. COYLER, Michael T. CORBETT, Daniel J. GRIFFIN, Andrew T. PARSONS, Joanna ROBINSON, Kyle QUASDORF
  • Publication number: 20230391771
    Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.
    Type: Application
    Filed: October 6, 2021
    Publication date: December 7, 2023
    Applicant: AMGEN INC.
    Inventors: Matthew G. BEAVER, Michael T. CORBETT, Yuanqing FANG, David D. FORD, Andrew T. PARSONS, Gabrielle ST-PIERRE, Reem TELMESANI
  • Publication number: 20230192681
    Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2,2?,2?-(1,3,5,2,4,6-trioxatriborinane-2,4,6-triyl)tris(3-fluorophenol), useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
    Type: Application
    Filed: November 13, 2020
    Publication date: June 22, 2023
    Inventors: Andrew T. PARSONS, Matthew BEAVER