Abstract: Systems and methods for monitoring and/or controlling a state of a subject during volume resuscitation are disclosed. One method includes acquiring cardiovascular data from a subject, obtaining previous volume administration information, and analyzing the cardiovascular data to determine a past time trajectory for at least one cardiovascular parameter. The method also includes determining a future state of the subject with and without additional volume administration using a statistical model, and determining, based on the future state of the subject, a likelihood that the at least one cardiovascular parameter will exceed or fall below a threshold at one or more pre-determined time points. The method further includes generating a report including a recommendation for administering an additional volume to the subject based on the determined likelihood and controlling administration of an additional fluid volume to the subject based on the report.

Abstract: Systems and methods for monitoring and/or controlling a cardiovascular system of a subject are disclosed. In some aspects, the method includes acquiring cardiovascular data from a subject, analyzing the cardiovascular data to determine a time trajectory for at least one cardiovascular parameter, and determining, using the time trajectory, a likelihood that the at least one cardiovascular parameter exceeds a threshold at one or more pre-determined time points. The method also includes determining a future cardiovascular state of the subject using the determined likelihood, and generating a report indicative of the future cardiovascular state of the subject. The method may also include estimating a dose response associated with at least one administered pharmaceutical agent for at least one cardiovascular parameter, and controlling the cardiovascular state of the subject at one or more pre-determined time points using the estimated dose response.

Abstract: A system is disclosed having a storage, a communications module for interacting with a medical measurement device, an analysis controller, and a test module that allows for the testing and evaluating of decision-support algorithms. A method for testing decision-support algorithms is disclosed having the steps of receiving into storage of a ruggedized, compact computer at least one decision-support algorithm; detecting with a communications module the initiation of a vital-sign monitoring session; receiving and storing vital-sign information into storage by the communications module; pushing the stored vital-sign information by an analysis controller to a test module running the stored at least one decision-support algorithm; and providing at least one output from the decision-support algorithm to at least one of a database and a display.

Abstract: A system is disclosed having a storage, a communications module for interacting with a medical measurement device, an analysis controller, and a test module that allows for the testing and evaluating of decision-support algorithms. A method for testing decision-support algorithms is disclosed having the steps of receiving into storage of a ruggedized, compact computer at least one decision-support algorithm; detecting with a communications module the initiation of a vital-sign monitoring session; receiving and storing vital-sign information into storage by the communications module; pushing the stored vital-sign information by an analysis controller to a test module running the stored at least one decision-support algorithm; and providing at least one output from the decision-support algorithm to at least one of a database and a display.

Abstract: A system is disclosed having a storage, a communications module for interacting with a medical measurement device, an analysis controller, and a test module that allows for the testing and evaluating of decision-support algorithms. A method for testing decision-support algorithms is disclosed having the steps of receiving into storage of a ruggedized, compact computer at least one decision-support algorithm; detecting with a communications module the initiation of a vital-sign monitoring session; receiving and storing vital-sign information into storage by the communications module; pushing the stored vital-sign information by an analysis controller to a test module running the stored at least one decision-support algorithm; and providing at least one output from the decision-support algorithm to at least one of a database and a display.

Abstract: A system is disclosed having a storage, a communications module for interacting with a medical measurement device, an analysis controller, and a test module that allows for the testing and evaluating of decision-support algorithms. A method for testing decision-support algorithms is disclosed having the steps of receiving into storage of a ruggedized, compact computer at least one decision-support algorithm; detecting with a communications module the initiation of a vital-sign monitoring session; receiving and storing vital-sign information into storage by the communications module; pushing the stored vital-sign information by an analysis controller to a test module running the stored at least one decision-support algorithm; and providing at least one output from the decision-support algorithm to at least one of a database and a display.

Abstract: An apparatus and methods for adaptive and autonomous calibration of pulse transit time measurements to obtain arterial blood pressure using arterial pressure variation. The apparatus and methods give pulse transit time (PTT) devices an ability to self-calibrate. The methods apply a distributed model with lumped parameters, and may be implemented, for example, using pulse transit time measurements derived from a wearable photoplethysmograph (PPG) sensor architecture with an intervening pressurizing mechanism.

Abstract: An apparatus and methods for adaptive and autonomous calibration of pulse transit time measurements to obtain arterial blood pressure using arterial pressure variation. The apparatus and methods give pulse transit time (PTT) devices an ability to self-calibrate. The methods apply a distributed model with lumped parameters, and may be implemented, for example, using pulse transit time measurements derived from a wearable photoplethysmograph (PPG) sensor architecture with an intervening pressurizing mechanism.

Abstract: An apparatus and methods for performing a circulatory measurement on an extremity, such as a hand, of a subject. The circulatory measurement results in the derivation of an output circulatory metric that may encompass blood pressure or various other circulatory metrics. An indicator of an input circulatory metric at a locus on the extremity is measured, such as a pulse transit time, and calibrated to account for the hydrostatic component of blood pressure arising due to vertical displacement of the extremity with respect to the heart.

Abstract: Methods and a computer program product for using a circulatory measurement on an extremity of a particular subject to derive an aortic blood pressure for that subject. A model is constructed that maps a peripheral cardiovascular waveform to a central cardiovascular waveform on the basis of a plurality of model parameters. A time record is obtained using a non-invasive blood pressure sensor disposed at a solitary position periphery of the cardiovascular system of a subject. The time record is then transformed to obtain a plurality of test central blood pressure waves, with a single test central blood pressure wave is based on each of a plurality of sets of values of the model parameters. An optimum set of values of the model parameters is then selected, based on a specified criterion applied to the plurality of test central blood pressure waves, so that the aortic circulatory waveform of the subject can be obtained.

Abstract: Methods and apparatus for measuring arterial blood pressure at an extremity of a subject. Arterial blood pressure is derived from a circulatory measurement performed on an extremity of a subject and the circulatory measurement is normalized to account for the instantaneous vertical displacement of the extremity. The vertical displacement of the extremity relative to the heart of the subject is obtained using the angular orientation of the subject's extremity. An improved photoplethysmograph can discriminate light traversing the extremity from ambient light on the basis of differential response. The apparatus may have a conducting polymer actuator for applying pressure to the extremity of the subject. A pulsatile waveform from the photoplethysmographic signal may be obtained at a plurality of externally applied pressures to calibrate the photoplethysmograph.