Patents by Inventor Andrew Tasker

Andrew Tasker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted amine derivatives and methods of use
    Patent number: 7514564
    Abstract: Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: April 7, 2009
    Assignee: Amgen Inc.
    Inventors: Guoqing Chen, Jeffrey Adams, Jean Bemis, Lucian Di Pietro, Celia Dominguez, Daniel Elbaum, Julie Germain, Qi Huang, Joseph L. Kim, Xiaohu Ouyang, Vinod F. Patel, Leon M. Smith, Andrew Tasker, Ning Xi, Shimin Xu, Chester Chenguang Yuan, Michael Croghan, Tae-Seong Kim
  • Treatment for Anxiety
    Publication number: 20090036376
    Abstract: The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.
    Type: Application
    Filed: July 1, 2008
    Publication date: February 5, 2009
    Applicants: NoNO Inc., Arbor Vita Corporation
    Inventors: Andrew Tasker, Tracy Doucette, Michael Tymianski, Kenneth Mendoza, Michael P. Belmares, David Garman, Peter S. Lu
  • Pyrazolo-pyridinone compounds and methods of use thereof
    Publication number: 20090012299
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, A3, A4, B, R1, R2, R3, R4 and R5 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
    Type: Application
    Filed: May 6, 2008
    Publication date: January 8, 2009
    Applicant: Amgen Inc.
    Inventors: Liping Pettus, Andrew Tasker, Shimin Xu, Ryan Wurz
  • Compounds and methods of use
    Patent number: 7435823
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: October 14, 2008
    Assignee: Amgen Inc.
    Inventors: Michele Potashman, Tae-Seong Kim, Steven Bellon, Shon Booker, Yuan Cheng, Joseph L. Kim, Andrew Tasker, Ning Xi, Shimin Xu, Jean-Christophe Harmange, George Borg, Matthew Weiss, Brian L. Hodous, Russell Graceffa, William H. Buckner, Craig E. Masse, Deborah Choquette, Matthew W. Martin, Julie Germain, Lucian V. DiPietro, Stuart C. Chaffee, Joseph J. Nunes, John L. Buchanan, Gregory J. Habgood, David C. McGowan, Douglas A. Whittington, Daniel La, Vinod F. Patel
  • Substituted pyridone compounds and methods of use
    Publication number: 20080249090
    Abstract: The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula I wherein A0-3 and R1-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
    Type: Application
    Filed: July 18, 2007
    Publication date: October 9, 2008
    Applicant: AMGEN INC.
    Inventors: Essa Hu, Jason Brooks Human, Roxanne Kunz, Andrew Tasker, Ryan White
  • Heterocyclic compounds and methods of use
    Publication number: 20080227779
    Abstract: The present invention comprises a new class of compounds capable of modulating the c-kit protein kinase and, accordingly, useful for treatment of c-kit mediated diseases including, without limitation, autoimmune disease, allergies, mastcytosis, mast cell related tumors and various fibrotic diseases. The compounds have a general Formula I wherein R1-5, X, Y and Z are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
    Type: Application
    Filed: July 18, 2007
    Publication date: September 18, 2008
    Applicant: AMGEN INC.
    Inventors: Ning Chen, Essa Hu, Roxanne Kunz, Shannon Rumfelt, Andrew Tasker
  • Calcium receptor modulating agents
    Publication number: 20080221101
    Abstract: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.
    Type: Application
    Filed: October 25, 2007
    Publication date: September 11, 2008
    Applicant: Amgen Inc.
    Inventors: Thomas S. Coulter, Adam James Davenport, Christopher H. Fotsch, Chiara Ghiron, Paul E. Harrington, Michael Gerard Kelly, Steve Fong Poon, Andrew Tasker, Ning Xi, Qing Ping Zeng
  • Imidazo- and triazolo-pyridine compounds and methods of use thereof
    Publication number: 20080161303
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
    Type: Application
    Filed: October 5, 2007
    Publication date: July 3, 2008
    Applicant: Amgen Inc.
    Inventors: Dawei Zhang, Andrew Tasker, Kelvin K.C. Sham, Partha Pratim Chakrabarti, James Richard Falsey, Bradley J. Herberich, Liping H. Pettus, Robert M. Rzasa
  • Compounds and methods of use
    Publication number: 20080161346
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: December 19, 2007
    Publication date: July 3, 2008
    Applicant: Amgen Inc.
    Inventors: Yuan Cheng, Deborah Choquette, Jean-Christophe Harmange, Andrew Tasker
  • Phthalazine, aza-and diaza-phthalazine compounds and methods of use
    Publication number: 20080119468
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
    Type: Application
    Filed: September 4, 2007
    Publication date: May 22, 2008
    Applicant: Amgen Inc.
    Inventors: Andrew Tasker, Dawei Zhang, Liping H. Pettus, Rob M. Rzasa, Kelvin K.C. Sham, Shimin Xu, Partha Chakrabarti
  • Thiadiazole compounds and methods of use
    Patent number: 7354944
    Abstract: The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: April 8, 2008
    Assignee: Amgen Inc.
    Inventors: Qingping Zeng, Guomin Yao, George Erich Wohlhieter, Vellarkad N. Viswanadhan, Andrew Tasker, James Thomas Rider, Holger Monenschein, Celia Dominguez, Matthew Paul Bourbeau
  • 2-Quinazolinone compounds and methods of use
    Publication number: 20080032973
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, s, T, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use such as treatment of kinase mediated diseases by administering the compounds of Formula I or compositions including the compounds of Formula I, and intermediates and processes useful for the preparation of compounds of Formula I.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 7, 2008
    Applicant: AMGEN INC.
    Inventors: Fang-Tsao Hong, Kelvin Sham, Seifu Tadesse, Andrew Tasker
  • Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
    Publication number: 20080032988
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R2 and R3 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
    Type: Application
    Filed: April 23, 2007
    Publication date: February 7, 2008
    Applicant: Amgen Inc.
    Inventors: Fang-Tsao Hong, James Falsey, Robert Rzasa, Seifu Tadesse, Andrew Tasker
  • Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
    Patent number: 7320992
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: January 22, 2008
    Assignee: Amgen Inc.
    Inventors: Christopher Tegley, Jeffrey A. Adams, Benny C. Askew, Jr., Michael Croghan, Daniel Elbaum, Julie Germain, Gregory J. Habgood, Scott Harried, Aiwen Li, Nobuko Nishimura, Rana Nomak, Andrew Tasker, Kevin Yang
  • Substituted anthranilic amide derivatives and methods of use
    Patent number: 7307088
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: December 11, 2007
    Assignee: Amgen Inc.
    Inventors: Qi Huang, Guoqing Chen, Aiwen Li, Babak Riahi, Andrew Tasker, Kevin Yang, Chester Chenguang Yuan
  • Nitrogen-containing bicyclic heteroaryl compounds and methods of use
    Publication number: 20070185324
    Abstract: The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z?, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
    Type: Application
    Filed: December 20, 2006
    Publication date: August 9, 2007
    Inventors: Frenel De Morin, Jian Chen, Elizabeth Doherty, Stephen Hitchcock, Qi Huang, Joseph Kim, Gang Liu, Thomas Nixey, Nick Paras, Jeffrey Petkus, Daniel Retz, Adrian Smith, Andrew Tasker, Jiawang Zhu
  • Thiazole compounds and methods of use
    Publication number: 20070173506
    Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
    Type: Application
    Filed: January 11, 2007
    Publication date: July 26, 2007
    Applicant: AMGEN INC.
    Inventors: Qingping Zeng, John Allen, Matthew Bourbeau, Celia Dominguez, Christopher Fotsch, Nianhe Han, Fang-Tsao Hong, Xin Huang, Matthew Lee, Aiwen Li, Qingyian Liu, James Rider, Seifu Tadesse, Andrew Tasker, Vellarkad Viswanadhan, Xianghong Wang, Kurt Weiler, George Wohlhieter, Guomin Yao, Chester Yuan
  • Bis-aryl kinase inhibitors and method
    Publication number: 20070054903
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: June 30, 2006
    Publication date: March 8, 2007
    Applicant: Amgen Inc.
    Inventors: Tae-Seong Kim, Jean-Christophe Harmange, Steven Bellon, Shon Booker, Noel D'Angelo, Celia Dominguez, Ingrid Fellows, Julie Germain, Timothy Harvey, Joseph Kim, Matthew Lee, Longbin Liu, Vinod Patel, Andrew Tasker
  • Aryl nitrogen-containing bicyclic compounds and methods of use
    Publication number: 20070054916
    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
    Type: Application
    Filed: September 30, 2005
    Publication date: March 8, 2007
    Inventors: Vinod Patel, Joseph Kim, Stephanie Geuns-Meyer, Stuart Chaffee, Victor Cee, Brian Hodous, Steven Bellon, Jean-Christophe Harmange, Philip Olivieri, Maya Thaman, Erin DiMauro, John Buchanan, David McGowan, Brian Albrecht, Holly Deak, Jean Bemis, Ryan White, Matthew Martin, Gregory Habgood, Paul Tempest, Craig Masse, William Buckner, Bradley Herberich, Russell Graceffa, Dawei Zhang, Shimin Xu, Kelvin Sham, Robert Rzasa, James Falsey, Partha Chakrabarti, Guo-Qiang Cao, Susan Tomlinson, Liping Pettus, Adrian Smith, Nick Paras, Gang Liu, Frenel DeMorin, Andrew Tasker, Anthony Reed
  • Substituted heterocycles and methods of use
    Publication number: 20060252777
    Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
    Type: Application
    Filed: November 29, 2005
    Publication date: November 9, 2006
    Applicant: AMGEN INC.
    Inventors: Tae-Seong Kim, Steven Bellon, Shon Booker, Noel D'Angelo, Celia Dominguez, Ingrid Fellows, Matthew Lee, Longbin Liu, Elizabeth Rainbeau, Aaron Siegmund, Andrew Tasker, Ning Xi, Yuan Cheng