Abstract: Various approaches for generating long-distance contiguity information to facilitate contig assembly and phase determination are disclosed. Nucleic acids are assembled into complexes using binding moieties such that, when the nucleic acid backbones are cleaved, the ensuing fragments remain bound. Exposed ends are tagged and ligated either to one another or to tagging moieties such as oligo labels. Ligated junctions are sequenced, and the sequence information is used to assemble contigs into common scaffolds or to assign phase information. Various approaches to tagging the exposed ends are presented.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: Disclosed herein is a magnetic storage device that includes magnetic storage discs and a first carriage arm rotatably movable in a radial direction along a first one of the magnetic storage discs and within a region radially outward from the first one of the magnetic discs. The magnetic storage device includes a first suspension arm co-movably fixed to the first carriage arm and having a first-suspension-arm length extending from a proximate first-suspension-arm end of the first suspension arm to a distal first-suspension-arm end of the first suspension arm. The magnetic storage device also includes a second suspension arm co-movably fixed to the first carriage arm and having a second-suspension arm length extending from a proximate second-suspension arm end to a distal second-suspension arm end of the second suspension arm that is different from the first-suspension arm length.

Abstract: Binary-phase-shift-key, phase-modulated waveforms with gigahertz bandwidths, suitable for kilowatt-class fiber amplifiers, can be narrowed back to the source laser's linewidth via second-harmonic, sum-frequency, or difference-frequency generation in a second-order nonlinear crystal. The spectrum of an optical signal phase-modulated with a pseudo-random bit sequence (PRBS) waveform recovers its original optical spectrum when frequency-doubled using second-harmonic generation (SHG). Conceptually, the PRBS waveform is cancelled by the SHG process, and the underlying laser spectrum is converted to the second-harmonic wavelength as though the PRBS modulation were not present. The same cancellation is possible with sum-frequency generation (SFG) and difference frequency generation (DFG), making it possible to construct high-power, narrow-linewidth lasers at wavelengths from the visible to the long-wave infrared.

Abstract: An autonomous pile driving system comprises an arm of an autonomous offroad vehicle (AOV) configured to hold and drive a pile, a chute configured to stabilize the pile as the pile is being driven. The autonomous pile driving system further comprises a controller configured to identify a location in the geographic area where a pile is to be driven (e.g., installed) and position the chute at the location. The controller aligns the pile secured by the AOV with an opening of the chute and inserts the pile into the chute by actuating an arm (or other suitable component) of the AOV securing the pile.

Abstract: Writing instruments with flexible nibs for reduced writing force in use are provided. A nib includes a nib body having a flexible upper writing portion and a lower portion in communication with the flexible upper writing portion, the lower portion of the nib body being configured to deliver ink to the flexible upper writing portion and the flexible upper writing portion being configured to deliver ink to a writing surface, wherein the flexible upper writing portion of the nib body has a flattened chisel-shaped tip at a superior end of the flexible upper writing portion, and wherein the nib is effective to deliver ink to the writing surface upon application of a force of less than about 0.1 lbs thereto.

Abstract: A system is provided for allowing temporary access to subscriber content through a network appliance. The system includes a server application residing on a platform server, an appliance application residing on the network appliance, and a mobile application residing on a mobile device. The server application determines the location of each of the network appliance and the mobile device. If they are within a set distance of one another, the server application allows for the temporary access to, and display of a subscriber's content on the network appliance. The server appliance can transmit a code to the network appliance, which the user then inputs into the mobile device.

Abstract: Acoustic filters, resonators and methods are disclosed. An acoustic filter device includes a substrate having a surface and a single-crystal piezoelectric plate having front and back surfaces, the back surface attached to the surface of the substrate except for a portion of the piezoelectric plate forming a diaphragm that spans a cavity in the substrate. An interdigital transducer is formed on the front surface of the piezoelectric plate with interleaved fingers of the IDT disposed on the diaphragm. At least a portion of a perimeter of the cavity is curved and at least one end zone of the perimeter of the cavity is round.

Abstract: A system is described that receives a query model of a query that includes one or more query commands. The query model includes a command model that corresponds to at least query command of the one or more query commands. The system uses the command model to generate an interactive action model summary and causes a user interface to display the query and the interactive action model summary in a query actions panel. A modification to the query in the user interface causes an update to the query actions panel and a modification to the action model summary causes an update to the at least one query command of the query.

Abstract: A computer network device (such as an access point, a switch or a router) that has multiple user interfaces is described. During operation, the computer network device may execute program instructions for the user interfaces and a shared messaging module, where a given user interface includes an agent corresponding to an application. When a message associated with the application is received via a user interface in the user interfaces, the corresponding agent in the user interface may extract a command or operation from the message. Then, the shared messaging module may translate the command or operation into a common format of the application. Moreover, the shared messaging module may provide (or route) the translated command or operation addressed to the application via a single communication path associated with the application and the agents for the application in the user interfaces.

Abstract: A wheel assembly bushing for in-wheel electric motors where the bushing includes a hydraulic chamber positioned within a resilient sleeve of the bushing and a helical fluid channel that extends helically about an inner bushing member between first and second fluid channel ends, which are arranged in fluid communication with the hydraulic chamber. An outer body extends annularly about the resilient sleeve, which permits relative movement between the inner bushing member and the outer body. The fluid channel is configured to produce inertance. This inertance, when combined with other damping and stiffness effects of the wheel assembly bushing, provides phase and magnitude shifts between force and velocity, which ultimately reduce magnetic gap deformation in the in-wheel electric motor.

Abstract: Authentication method and systems using RFID-enabled payment cards are disclosed herein where a server receives a request corresponding to authorization of a payment associated with a payment card from an electronic terminal. The server identifies an electronic device of a user associated with the payment card. The server then transmits an instruction to the electronic device to cause an RFID reader of the electronic device to determine whether an RFID tag corresponding to the payment card is located within a predetermined proximity to the electronic device. When the payment card is located within the predetermined proximity, the server executes a first authentication protocol. Moreover, when the payment card is not located within the predetermined proximity, the server executes a second authentication protocol, wherein the second authentication protocol is more restrictive than the first authentication protocol.

Abstract: An approach for fully automating the use of robotic devices in a laboratory workflow includes defining sequences for automating tasks and equipment involved in such a workflow, and calculating a path for each sequence that resolves get, handoff, and placement procedures. The approach develops a schedule that executes resolved pathways in and between each device. The approach is provided with an easy-to-use interface, in which a user drags and drops devices to automatically configure them, defines operations to be performed by these devices, and then runs the laboratory workflow. The interface also provides the ability to monitor progress of the workflow, and make modifications and adjustments as needed.

Abstract: Math-based currency (“MBC”) transactions are inherently quasi-anonymous. Systems and methods of registering customers with a financial institution for the purposes of opening a MBC account are described. During the registration process, the financial institution gathers and stores certain information relating to the customers having MBC accounts. This information may later be used to provide verification of MBC transactions to other parties involved in the MBC transactions.

Abstract: The present invention provides a regulatory T (Treg) cell expressing an antigen chimeric receptor (CAR) comprising a) at least one antigen binding domain, b) a transmembrane domain, and c) a cytoplasmic signaling domain comprising at least one primary cytoplasmic signaling domain and at least the co-stimulatory signaling domain of CD137, wherein said antigen binding domain specifically binds an antigen that is expressed on the surface of a target cell or a tag of a tagged polypeptide that binds to an antigen expressed on the surface of a target cell or a soluble antigen. Compositions comprising said Treg cells, and methods of enrichment and analysis of activated Tregs that express said CAR are also disclosed.

Abstract: Systems and methods for capturing and rendering light fields for head-mounted displays are disclosed. A mediated-reality visualization system includes a head-mounted display assembly comprising a frame configured to be mounted to a user's head and a display device coupled to the frame. An imaging assembly separate and spaced apart from the head-mounted display assembly is configured to capture light-field data. A computing device in communication with the imaging assembly and the display device is configured to receive light-field data from the imaging assembly and render one or more virtual cameras. Images from the one or more virtual cameras are presented to a user via the display device.

Abstract: According to a first aspect of the invention, there is provided a programmable system for a munition, comprising: an electroacoustic transducer, arranged to receive an acoustic signal comprising data, and convert that signal into an electrical signal comprising data; a processor, arranged to receive and process the electrical signal comprising data, and to use that data in programming of the programmable system.

Abstract: An arrangement for medical equipment configured to appear more desirable to the patient is provided. The present disclosure provides an arrangement of intravenous infusion equipment configured to appear as an ordinary household object. The arrangement of intravenous infusion equipment may be configured to appear as an object fitting into the patient's interests in order to make the patient more relaxed and comfortable. The arrangement of intravenous infusion equipment may be configured to appear as an object more desirable to the patient while the equipment is not in use and then extend into a more suitable position when the equipment is in use.

Abstract: Systems, methods, and instructions for reordering consumer products can include: (A) receiving an image of a physical depiction of an identification tag, (B) determining the consumer product that corresponds to the identification tag via at least one of: (i) optical character recognition, (ii) universal resource identifier decoding, (iii) object recognition, (iv) quick response code decoding, or (v) barcode decoding, (C) determining a retail location wherein the consumer product is not currently in stock and is expected to be in stock and available for pick-up at the retail location in the future, and (D) automatically initiating the reordering of the consumer product at the retail location.